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Persistent increase of Nogo-A-positive cells and dynamic reduction in oligodendroglia lineage cells in white matter regions following experimental and clinical traumatic brain injury
White matter (WM) disruption and atrophy is a consequence of traumatic brain injury (TBI) and contributes to persisting cognitive impairment. An increased expression of the myelin-associated axonal outgrowth inhibitor Nogo-A and oligodendrocyte pathology might be negatively associated with postinjury WM changes. Here, we analyzed brain tissue from severe TBI patients, obtained by surgical decompre
Bilayer orthogonal ferromagnetism in CrTe2-based van der Waals system
Systems with pronounced spin anisotropy are pivotal in advancing magnetization switching and spin-wave generation mechanisms that are fundamental to spintronic technologies. Quasi-van der Waals ferromagnets like Cr1+δTe2 represent seminal materials in this field, renowned for their delicate balance between frustrated layered geometries and magnetism. Despite extensive investigation, the nature of
Explaining and Understanding Trump's 'America First Trade Policy'
Characterization of Portable Ultra-Low Field MRI Scanners for Multi-Center Structural Neuroimaging
The lower infrastructure requirements of portable ultra-low field MRI (ULF-MRI) systems have enabled their use in diverse settings such as intensive care units and remote medical facilities. The UNITY Project is an international neuroimaging network harnessing this technology, deploying portable ULF-MRI systems globally to expand access to MRI for studies into brain development. Given the wide ran
Charge carrier dynamics controlling performance of lead-based halide perovskite solar cells
We review our studies to assess charge carrier dynamics inside a perovskite film and interfacial charge transfer dynamics for a perovskite layer sandwiched by an electron transporting layer (ETL) such as TiO2 compact or mesoporous layer and a hole transporting layer (HTL) such as spiro-OMeTAD. Both electron and hole injection occur faster than electron-hole recombination inside a perovskite film,
Gene expression-based identification of prognostic markers in lung adenocarcinoma
Introduction Many studies have aimed at identifying additional prognostic tools to guide treatment choices and patient surveillance in lung cancer by assessing the expression of individual proteins through immunohistochemistry (IHC) or, more recently, through gene expression-based signatures. As a proof-of-concept, we used a multi-cohort, gene expression-based discovery and validation strategy to
A shift in Japan’s fight against child sex tourism in Asia
Japan’s warning wasn’t triggered by a government audit or diplomatic scandal. It came because a citizen saw concerning social media posts and decided to act.
Illuminating the Invisible: Green Fluorescent Protein as a Beacon for Antibiotic-Induced Phage Activity in Escherichia coli.
Background/Objectives: Antibiotic resistance presents an urgent public health threat. By developing a streamlined and effective method for studying bacteriophage induction, this research marks a step further in understanding how antibiotic-resistant genes might spread across different environments. This knowledge is essential for creating strategies to reduce the spread of antimicrobial resistanc
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Tumor response mechanisms and treatment effects of alpha1-oleate
Impact of different carbon labels on consumer inference
Carbon labelling of food products serves as a demand-side tool with the potential to drive the essential shift in consumption patterns toward reducing climate impact. For carbon labels to influence food choices, they must enable consumers to recognize and adopt purchasing behaviour that lower their climate footprint. While inference plays a critical role in facilitating behavioural change, evidenc
Using SILMAS to improve machine learning-assisted quantification of pathology
In this study, we investigate the benefits of using structured illumination light-sheet microscopy with axial sweeping (SILMAS) in the context of neural network-assisted quantification of pathology in volumetric data. A bottleneck for training a neural network is the availability of manually labeled training data that adequately covers the variance in unseen samples, allowing the network to correc
Tourism satellite account for Sweden 1992-93
This paper calculates the consumption expenditure of internal visitors in Sweden, and Swedes' expenditures on outboard tourism, according to the WTO definition of tourism expenditure. The demand-based calculations of national tourism are distributed among same-day visitors and overnight visitors, for leisure and business purposes. The supply side calculations cover the main tourism industries. Dai
A new approach to modelling and forecasting monthly guest nights in hotels
Starting from a day-to-day model on hotel specific guest nights we obtain an integer-valued moving average model by cross-sectional and temporal aggregation. The two parameters of the aggregate model reflect mean check-in and the check-out probability. Letting the parameters be functions of dummy and economic variables we demonstrate the potential of the approach in terms of interesting interpreta
Enhancing Photothermal Therapy Against Breast Cancer Cells by Modulating the End Point of Gold Shell-Isolated Nanoparticles Using Nanostraw-Assisted Injection
Gold shell-isolated nanoparticles (AuSHINs) are promising photothermal therapy (PTT) agents for cancer treatment due to their excellent photoconversion efficiency, biocompatibility, colloidal stability, and tunable properties, including size, shape, and surface functionalization. However, their therapeutic efficacy in in vitro assays is often limited by poor cellular uptake and lysosomal entrapmen
Aerosolized Dornase Alfa (DNase I) for the Treatment of Severe Respiratory Failure in COVID-19 : A Randomized Controlled Trial
Background: Lung injury in COVID-19 is characterized by neutrophil invasion and the release of neutrophil extracellular traps (NETs). An aberrant NET formation may induce local inflammation and increase sputum viscosity. Inhalation of DNase I (dornase alfa) is a treatment option that degrades NETs in the airways. Previous case series have indicated positive clinical effects of inhaled dornase alfa
Cloud-scale Gas Properties, Depletion Times, and Star Formation Efficiency per Freefall Time in PHANGS-ALMA
We compare measurements of star formation efficiency to cloud-scale gas properties across the PHANGS- ALMA sample. Dividing 67 galaxies into 1.5 kpc scale regions, we calculate the molecular gas depletion time τ dep mol = Σ mol / Σ SFR and the star formation efficiency per freefall time ϵ ff mol = τ ff / τ dep mol for each region. Then we test how τ dep mol and ϵ ff mol vary as functions of the re
