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Lysostaphin is a bacteriolytic enzyme targeting peptidoglycan, the essential component of the bacterial cell envelope. It displays a very potent and specific activity toward staphylococci, including methicillin-resistant Staphylococcus aureus. Lysostaphin causes rapid cell lysis and disrupts biofilms, and is therefore a therapeutic agent of choice to eradicate staphylococcal infections. The C-term
Enzyme regulation is vital for metabolic adaptability in living systems. Fine control of enzyme activity is often delivered through post-translational mechanisms, such as allostery or allokairy. β-phosphoglucomutase (βPGM) from Lactococcus lactis is a phosphoryl transfer enzyme required for complete catabolism of trehalose and maltose, through the isomerisation of β-glucose 1-phosphate to glucose
The popularity of digital gaming among older adults is on the rise, necessitating a deeper understanding of this phenomenon. Drawing upon the concepts and theoretical perspectives in domestication theory, actor network theory, and media engagement theory, we explored the digital gameplay experiences of older adults in China’s sociocultural contexts. We conducted in-depth interviews with 12 adults
Recent scholarly attention has focused on YouTubers' advertising practices and their influence on young followers' understanding of commercial content. Although previous studies primarily explore children's advertising literacy, they often treat YouTubers' influencer marketing as a unified phenomenon. This article distinguishes between two types of advertising: sponsored content and merchandise (m
Background: In prostate cancer (PCa), questions remain on indications for prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging and PSMA radioligand therapy, integration of advanced imaging in nomogram-based decision-making, dosimetry, and development of new theranostic applications. Objective: We aimed to critically review developments in molecular hybrid imaging an
Symmetry and dominance breaking can be crucial for solving hard combinatorial search and optimisation problems, but the correctness of these techniques sometimes relies on subtle arguments. For this reason, it is desirable to produce efficient, machine-verifiable certificates that solutions have been computed correctly. Building on the cutting planes proof system, we develop a certification method
Purpose: To demonstrate the technical feasibility and the value of ultrahigh-performance gradient in imaging the prostate in a 3T MRI system. Methods: In this local institutional review board–approved study, prostate MRI was performed on 4 healthy men. Each subject was scanned in a prototype 3T MRI system with a 42-cm inner-diameter gradient coil that achieves a maximum gradient amplitude of 200 m
Recent successful cardiac transplantation from pig to non-human primates and the first pig-to-human transplantation has put the focus on the properties of the pig heart. In contrast to the coronary arteries, the coronary veins are less well characterized and the aim was to examine the mechanical and pharmacological properties of coronary veins in comparison to the arteries. Vessel segments from th
How people distinguish well-justified from poorly justified arguments is not well known. To study the involvement of intuitive and analytic cognitive processes, we contrasted participants’ personal beliefs with argument strength that was determined in relation to established criteria of sound argumentation. In line with previous findings indicating that people have a myside bias, participants (N =
Aims Our objective was to assess changes in the birth prevalence of CHD over a half-century in a high-resource, nationwide setting, as well as changes in the prevalence of cardiac interventions in this population. Methods The Swedish National Patient and Cause of Death registers were linked to estimate the annual rates of CHD and cardiac and results interventions among live-born infants from 1970
Immunoglobulin G4-related disease (IgG4-RD), which was initially identified as a type of autoimmune pancreatitis around the year 2000, is now widely acknowledged to be a systemic sickness. Based on both general and organ-specific criteria, alongside laboratory measurements of IgG4-subtype, the diagnosis is made. The diagnosis requires, however, a heightened index of suspicion, especially given the
