Paternal or maternal deletions in the 15q11.2-q13 region are known to result in Prader-Willi syndrome (PWS) or Angelman syndrome (AS), respectively. Maternal duplications in 15q11.2-q13 have been found in patients with autism. A population of adults with moderate to profound mental retardation was studied to examine the usefulness of PCR based molecular methods in screening for proximal chromosome

Purpose Patients' understanding of their illness is key for making informed treatment decisions, yet studies suggest an association between prognostic awareness and worse quality of life (QOL) and mood among patients with advanced cancer. We sought to explore the relationships among prognostic awareness, coping, QOL, and mood in patients with newly diagnosed, incurable cancer. Methods We assessed

Do you ever hear a medical term (e.g., demoralization) and wonderwhy it wasn’ t discussed in medical school? Do you ever wonderwhether some words or concepts mean the same thing to all practitioners?If you have, then the following case vignette should provide theforum to discuss the evolution of some terms and help you decide how toapply them.

Outpatient palliative care is increasingly delivered through co-management, a collaborative model of care that enables palliative care clinicians and oncologists to coordinate efforts. Here, we offer a distillation of our experience with co-management at a large teaching hospital. We describe three strategies to implement co-management: a shared understanding of each subspecialty, a shared framewo

BACKGROUND: Serious illness communication is a key element of high-quality care, but it is difficult to implement in practice. The Serious Illness Care Program (SICP) is a multifaceted intervention that contributes to more, earlier, and better serious illness conversations and improved patient outcomes. This qualitative study examined the organizational and implementation factors that influenced i

In the Vault, CvsD is thrilled to present Radiant Exposures—Facts Run on Light Beams These Days, which returns to Italian-born, Berlin-based artist Rosa Barba's longstanding motifs of the desert and exploration of modern archives as manifestation of human desire for progress. The central image of the film is the human-made landscape with large expanses of rectangular panels reflecting the sunlight

Strength, ductility, and failure properties of metals are tailored by plastic deformation routes. Predicting these properties requires modeling of the structural dynamics and stress evolution taking place on several length scales. Progress has been hampered by a lack of representative 3D experimental data at industrially relevant degrees of deformation. We present an X-ray imaging based 3D mapping

Oxygen-enriched air combustion holds promise as an effective method for harnessing blast furnace gas (BFG) in the steel industry. In this study, the laminar burning velocities of blast furnace gas were measured using the heat flux method under elevated oxygen mole fractions (0.3–1.0) and temperatures (303–353 K). Subsequently, the measured data were used to evaluate the GRI-Mech 3.0, Li, FFCM-1, a

Vagococcus lutrae belongs to the Vagococcus genus; it is possible to isolate vagococci from marine hosts, contaminated food and soil. To our knowledge, this is the first case of bloodstream infection with V. lutrae and only the second reported human infection in the literature. As in the first reported case of clinical infection with V. lutrae, this woman had several wounds. The clinical investiga

Ischemia-reperfusion injury (IRI) plays a crucial role in the development of primary graft dysfunction (PGD) following lung transplantation. A promising novel approach to optimize donor organs before transplantation and reduce the incidence of PGD is mitochondrial transplantation. In this study, we explored the delivery of isolated mitochondria in 4 hour ex vivo lung perfusion (EVLP) before transp

In Denmark, the incidence of carbapenemase-producing organisms (CPO) is increasing, and a coordinated national strategy is needed. We describe a case story of a 40-year-old woman transferred to a Danish hospital with severe complications after cosmetic surgery in the Middle East. She had an intra-abdominal infection with three different CPO, one of them co-resistant to colistin, one of the few rem