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Antibody binding to bacterial surfaces plays a crucial role in immunity, and a key characteristic of this protein-protein interaction is the binding affinity. Determining the affinity of an antibody binding to its antigen is the first step in predicting the function in a physiological environment where other competing protein interactions may be present. Antibody-antigen affinity is often evaluate
Climate change is an important driver of range shifts and community composition changes. Still, little is known about how the responses are influenced by the combination of land use, species interactions and species traits. We integrate climate and distributional data for 131 butterfly species in Sweden and Finland and show that cumulative species richness has increased with increasing temperature
The purpose of this systematic review and meta-analysis is to determine the effect of lockdowns, also referred to as ‘Covid restrictions’, ‘social distancing measures’ etc., on COVID-19 mortality based on available empirical evidence. We define lockdowns as the imposition of at least one compulsory, non-pharmaceutical intervention (NPI). We employ a systematic search and screening procedure in whi
Background: While citizen science approaches are emerging within both social and health sciences, projects aimed at improving the living conditions of older adults remain rare. To enable forward-looking housing provision for the ageing population, valid and detailed information is needed on environmental barriers in the housing stock. Moreover, to promote active ageing and avoid involuntary moves
Financial security influences good quality housing, health, and longevity, but few recent studies of the financial aspects of aging in place have been published. We explored strategies used to age in place and thoughts about future housing among women aged 65 and older living with a low pension in Sweden. We conducted semi-structured qualitative interviews with 13 women aged 65 and older with a lo
This article presents two German Catholic prayer books written by the two sixteenth-century priests Johann Faber OP and Peter Michael Brillmacher SJ – known for their catechetical and apologetical work in areas of confessional division. Adding to the claims by early twentieth-century researchers that these books were used for “resisting and combating Protestantism,” I argue that they were tools fo
This detailed volume presents a diverse set of methodological approaches designed to improve our understanding of bacterial infections from a wide range of bacterial species. Beginning with biofilms and subcellular compartments, the book explores transcriptional analysis, methods for studying plasmid dynamics, and tools for phylogenetic analysis of bacterial genomes, as well as bacterial effector
In this paper, I track the arrival of the sugar beet in Scandinavia and explore the technical changes, ecological implications and new social arrangements that followed in its wake. Based on ethnographic records and other historical material dealing with agricultural practices, I argue that an ethnological view that takes the agrarian landscape and the organisation of social life together as one a
Achromobacter is a genus of Gram-negative rods, which can cause persistent airway infections in people with cystic fibrosis (CF). The knowledge about virulence and clinical implications of Achromobacter is still limited, and it is not fully established whether Achromobacter infections contribute to disease progression or if it is a marker of poor lung function. The most commonly reported Achromoba
The Oslofjord subsea road tunnel is a unique environment in which the typically anoxic marine deep subsurface is exposed to oxygen. Concrete biodeterioration and steel corrosion in the tunnel have been linked to the growth of iron- and manganese-oxidizing biofilms in areas of saline water seepage. Surprisingly, previous 16S rRNA gene surveys of biofilm samples revealed microbial communities domina
Natural climate solutions are being advanced to arrest climate warming by protecting and enhancing carbon capture and storage in plants, soils and sediments in ecosystems. These solutions are viewed as having the ancillary benefit of protecting habitats and landscapes to conserve animal species diversity. However, this reasoning undervalues the role animals play in controlling the carbon cycle. We
Herbivores can exert a controlling effect on the reproduction and growth of shrubs, thereby counter-acting the climate-driven encroachment of shrubs in the Arctic and the potential consequences. This control is particularly evident in the case of abundant herbivores, such as reindeer (Rangifer tarandus tarandus), whose grazing patterns are affected by management. Here, we tested how different rein
We study the distribution of eigenvalues of almost-Hermitian random matrices associated with the classical Gaussian and Laguerre unitary ensembles. In the almost-Hermitian setting, which was pioneered by Fyodorov, Khoruzhenko and Sommers in the case of GUE, the eigenvalues are not confined to the real axis, but instead have imaginary parts which vary within a narrow “band” about the real line, of
Data independent acquisition mass spectrometry (DIA-MS) has recently emerged as an important method for the identification of blood-based biomarkers. However, the large search space required to identify novel biomarkers from the plasma proteome can introduce a high rate of false positives that compromise the accuracy of false discovery rates (FDR) using existing validation methods. We developed a
Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer with high heterogeneity and poor therapeutic responses to standard treatments. The use of herbal medicine for treatment of TNBC is gaining in popularity worldwide due to their better anti-tumor efficacy and less side effects compared to chemotherapy agents. Previous studies have shown that crocin, a natural carotenoid
