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Background: Standardized techniques to detect HIV-neutralizing antibody responses are of great importance in the search for an HIV vaccine. Methods: Here, we present a high-throughput, high-content automated plaque reduction (APR) assay based on automated microscopy and image analysis that allows evaluation of neutralization and inhibition of cell-cell fusion within the same assay. Neutralization
Ett bråk passerar sällan obemärkt, tvärtom väcker det människors intresse och engagemang. Men vad innebär uppmärksamheten för bråkets utveckling? Hur hanteras en mellanmänsklig konflikt? Denna rapport berättar om bråkets betydelse, varierande förlopp och hantering i ungdomsvården utifrån etnografiskt material (observationer och intervjuer) från framför allt en institution, här kallad Silverbäcken.
Although patients undergoing hemodialysis treatment often suffer from cardiovascular disease, monitoring of cardiac rhythm is not performed on a routine basis. Without requiring any extra sensor, this study proposes a method for extracting a cardiac signal from the built-in extracorporeal venous pressure sensor of the hemodialysis machine. The extraction is challenged by the fact that the cardiac
ABSTRACT: Genetically engineered Saccharomyces cerevisiae strains are able to ferment xylose present in lignocellulosic biomass. However, better xylose fermenting strains are required to reach complete xylose uptake in simultaneous saccharification and co-fermentation (SSCF) of lignocellulosic hydrolyzates. In the current study, haploid Saccharomyces cerevisiae strains expressing a heterologous xy
The phenotype of smooth muscle cells is regulated by multiple environmental factors including mechanical forces. Mechanical stretch of mouse portal veins ex vivo has been shown to promote contractile differentiation by activation of the Rho-pathway, an effect that is dependent on the influx of calcium via L-type calcium channels. MicroRNAs have recently been demonstrated to play a significant role
We present a new class of iteratively decodable turbo-like codes, called braided convolutional codes. Constructions and encoding procedures for tightly and sparsely braided convolutional codes are introduced. Sparsely braided codes exhibit good convergence behavior with iterative decoding, and a statistical analysis using Markov permutors shows that the free distance of these codes grows linearly
Background: It has been suggested that changes in prostate-specific antigen (PSA) over time (ie, PSA velocity [PSAV]) aid prostate cancer detection. Some guidelines do incorporate PSAV cut points as an indication for biopsy. Objective: To evaluate whether PSAV enhances prediction of biopsy outcome in a large, representative, population-based cohort. Design, setting, and participants: There were 27
Co-C-protected amino acid (C-protected L-histidine, L-tyrosine, L-cysteine and L-cystine) complexes were covalently grafted onto chloropropylated silica gel, and the materials thus obtained were structurally characterised by mid/far IR and X-ray absorption spectroscopies. The superoxide dismutase-like activities of the substances were determined via the Beauchamp-Fridovich test reaction. It was fo
The (CH3D)-C-13/(CH4)-C-12 kinetic isotope effect, alpha((CH3D)-C-13), of CH4 + Cl is determined for the first time, using the relative rate technique and Fourier transform infrared (FTIR) spectroscopy. alpha((CH3D)-C-13) is found to be 1.60 +/- 0.04. In addition, a quantum chemistry/transition state theory model with tunneling correction is constructed and the primary cause for alpha((CH3D)-C-13)
Stretching DNA in nanochannels is a useful tool for direct, visual studies of genomic DNA at the single molecule level. To facilitate the study of the interaction of linear DNA with proteins in nanochannels, we have implemented a highly effective passivation scheme based on lipid bilayers. We demonstrate virtually complete long-term passivation of nanochannel surfaces to a range of relevant reagen
Conflicts in traffic stream have been detected by different safety performance indicators. This study aims to empirically investigate the differences between different indicators in detecting rear-end conflicts and assessing the risk in an uninterrupted flow. Micro-level data of a 24-hr traffic stream (including 6,657 vehicles) were captured using inductive loop detectors installed on a rural free
Background: Rye products have previously been shown to induce comparatively low post-prandial insulin responses; irrespectively of their glycaemic indices (GI). However, the mechanism behind this lowered insulin demand remains unknown. An improved insulin economy might contribute to the benefits seen in epidemiological studies with whole grain diets on metabolic risk factors and weight regulation.
OBJECTIVE: The appearance of "covert" saccades in the head impulse test in patients with vestibular loss may lead to diagnostic misinterpretations. Here, we demonstrate a procedure that can convert covert eye saccades to overt when performing the head impulse test. PATIENTS: Patients with known vestibular deficits that have covert saccades during head impulse test. INTERVENTION: Diagnostic: random
Recension av Björn Fontander, De lydiga kreaturen i Bishop Hill.
Streptococcus pyogenes is the causative agent in a wide range of diseases in humans. Thrombin-activatable fibrinolysis inhibitor (TAFI) binds to collagen-like proteins ScIA and ScIB at the surface of S. pyogenes. Activation of TAFI at this surface redirects inflammation from a transient to chronic state by modulation of the kallikrein/kinin system. We investigated TAFI binding characteristics to S
During the last couple of decades it has become obvious that the aristocracy created elite landscapes around their castles. The purpose of this paper is to discuss the presence of late medieval elite aristocratic landscapes in Scandinavia. The castles of Bergkvara in medieval Sweden and Glimmingehus and Gurre in medieval Denmark are discussed. The result shows that the Scandinavian aristocracy use
