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The DEK oncogene is highly expressed in cells from most human tissues and overexpressed in a large and growing number of cancers. It also fuses with the NUP214 gene to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. Originally characterized as a member of this translocation, DEK has since been implicated in epigenetic and transcriptional regulation but its role in these proc
Patients with chronic renal failure show a greater incidence of malignancies. We evaluated whether moderately impaired renal function at baseline influenced risk of all cancers during long-term follow in young persons. Our cohort included 33,346 subjects, aged 26-61 years at baseline, in a representative, population-based study enrolling subjects from 1974 to 1992. Median follow-up time was 28 yea
A summary of the constraints from the ATLAS experiment on R-parity-conserving supersymmetry is presented. Results from 22 separate ATLAS searches are considered, each based on analysis of up to 20.3 fb(-1) of proton-proton collision data at centre-of-mass energies of root s = 7 and 8TeV at the Large Hadron Collider. The results are interpreted in the context of the 19-parameter phenomenological mi
Recent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown.
A new method is reported on how to measure the local pressure amplitude and the Q factor of ultrasound resonances in microfluidic chips designed for acoustophoresis of particle suspensions. The method relies on tracking individual polystyrene tracer microbeads in straight water-filled silicon/glass microchannels. The system is actuated by a PZT piezo transducer attached beneath the chip and driven
Introduction Left frontal brain lesions are known to give rise to aphasia and impaired word associations. These associations have previously been difficult to analyze. We used a semantic space method to investigate associations to cue words. The degree of abstractness of the generated words and semantic similarity to the cue words were measured. Method Three subjects diagnosed with Broca’s aphasia
The antioxidant and anti-inflammatory effects of hexane (HEXA), chloroform (CHLORO), ethyl acetate (EA) and total alcoholic (T. ALCOH) extracts of Marrubium alysson in hypercholesterolemic-fed rabbits were evaluated. Hypercholesterolemia was induced in male rabbits by high cholesterol diet (HCD) (350 mg/kg) for 8 weeks. Hypercholesterolemic rabbits were allocated into groups, treated with simvasta
Cambrian trilobites mainly lived on the sea floor, and up till now few, if any, unequivocally planktonic trilobites have been reported from earlier than the Ordovician. The late Cambrian (Furongian) to late Ordovician olenids are a distinctive group of benthic (sea-floor dwelling) or nekto-benthic trilobites. Here we show, however, that one recently described, miniaturized and very spiny olenid sp
Mesenchymal stem cells have shown regenerative properties in many tissues. This feature had originally been ascribed to their multipotency and thus their ability to differentiate into tissue-specific cells. However, many researchers consider the secretome of mesenchymal stem cells the most important player in the observed reparative effects of these cells. In this review, we specifically focus on
Adsorption of thymine on a defined Cu(110) surface was studied using reflection-absorption infrared spectroscopy (RAIRS), temperature programmed desorption (TPD), and scanning tunnelling microscopy (STM). In addition, density functional theory (DFT) calculations were undertaken in order to further understand the energetics of adsorption and self-assembly. The combination of RAIRS, TPD, and DFT res
Objective: The vagina makes a major contribution to the normal female sexual response cycle. An increase in vaginal blood flow is considered a key event in the mechanism of sexual arousal. Recent research has focused mainly on the cyclic GMP pathway and phosphodiesterase type 5 (PDE5, cyclic GMP specific PDE) in the control of vaginal vascular smooth muscle, whereas only little is known on the rol
Theoretical arguments, supported by other indirect evidence, suggest that the wave function of high-x partons should be narrower than that of low-x ones. In this article, we present a modification to the variable impact parameter framework of PYTHIA 8 to model this effect. In particular, a Gaussian hadronic matter profile is introduced, with a width dependent on the x value of the constituent bein
Gaia, the next astrometric mission of the European Space Agency, will use a camera composed of 106 CCDs to collect multiple observations for one billion stars. The astrometric core solution of Gaia will use the estimated location of the stellar images on the CCDs to derive the astrometric parameters (position, parallax and proper motion) of the stars. The Gaia CCDs will suffer from charge transfer
Abstract in UndeterminedEmployees working across multiple cultures are exposed to a vast number of different norms and values, and consequentially work is often a struggle to retain a coherent sense of self. However, when international workers travel, they also encounter more bland spaces where familiarity and similarity are important. These spaces appear culturally generic to the Western traveler
In a recent article Emanuel Adler and Vincent Pouliot argued that attention to 'practices' could help IR scholars overcome ontological gaps and provide a new basis, on which the discipline could be established. Four such dichotomies are particularly salient: between the material and the meaningful, the rational and the practical, between agencies and structures, and between the forces of stability
CHEP Conferences are dedicated to a quite specific scientific computing domain, and deal with rather specialised software, developed for the needs of the High Energy Physics community. The sheer size of this community created an environment which until recently has been to a large extent isolated from the mainstream computing. There is however an emerging trend for the computing solutions to spill
Background: Hemophilia A (HA) has a high level of variation within the disease class, with more than 1000 mutations being listed in the HAMSTeRS database. At the same time a number of F8 mutations are present in specific populations at high frequencies. Objectives: The simultaneous presence of large numbers of rare mutations and a small number of high-frequency mutations raises questions about the
Changes in solar activity have previously been proposed to cause decadal- to millennial-scale fluctuations in both the modern and Holocene climates(1). Direct observational records of solar activity, such as sunspot numbers, exist for only the past few hundred years, so solar variability for earlier periods is typically reconstructed from measurements of cosmogenic radionuclides such as Be-10 and
