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INTRODUCTION: We examined whether baseline glial markers soluble triggering receptor expressed on myeloid cell 2 (sTREM2), chitinase 3-like protein 1 (YKL-40), and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF), and plasma GFAP are associated with cognitive change in cognitively unimpaired (CU) individuals at risk of Alzheimer's disease (AD). METHODS: A total of 353 CU (mean a
There has been a long-standing interest in targeting the type 1 insulin-like growth factor receptor (IGF-1R) signaling system in breast cancer due to its key role in neoplastic proliferation and survival. However, no IGF-1R targeting agent has shown substantial clinical benefit in controlled phase 3 trials, and no biomarker has been shown to have clinical utility in the prediction of benefit from
Opus 106b. Composition: Alexander von Zemlinsky. Lyrics by Ferdinand Gregorovius, Constance Bache. A version of this work already exists for soprano and chamber orchestra, but I have adapted it for soprano and string quartet.
Introduction: Little is known of the processes that trigger neutrophil activation in the joint of patients with oligoarticular juvenile idiopathic arthritis (oJIA), and if synovial fibroblasts (S-Fib) play an important role in the activation. Therefore, we aimed to investigate whether S-Fib derived from oJIA patients drive neutrophil activation. Methods: Synovial fluid (SF) was collected from pati
Charge transfer between molecules lies at the heart of many chemical processes. Here, we focus on the ultrafast electron dynamics associated with the formation of charge-transfer-to-solvent (CTTS) states following X-ray absorption in aqueous solutions of Na+, Mg2+, and Al3+ ions. To explore the formation of such states in the aqueous phase, liquid-jet photoemission spectroscopy is employed. Using
The emergence of pandemics like Covid-19 has raised important issues regarding the safe utilisation of spaces due to the potential for virus transmission in both enclosed and open built environments. This chapter explores the challenges posed by pandemics in terms of safe space utilisation, considering the potential virus transmission risks. It presents a risk analysis methodology that makes use o
While there is substantial evidence on excess mortality in the first two years of the COVID-19 pandemic, no study has conducted a cause-specific analysis of excess mortality for the whole period 2020–2022 across multiple countries. We examined cause-specific excess mortality during 2020–2022 in Denmark, Finland, Norway, and Sweden—four countries with similar demographics and welfare provisions, wh
In this work, numerical investigations were performed using large eddy simulations and validated against detailed measurements in the CeCOST swirl stabilised burner. Both cold and reactive flow have been studied and the model has shown a good agreement with experiments. The verification of the model was done using the LES index of quality and a single grid estimator. The cold flow simulations pred
Farmers are key to preserving and restoring semi-natural pastures (SNPs) while maintaining their environmental and cultural significance. To support these efforts, it is essential to create favorable conditions that encourages voluntary participation of farmers in agri-environment-climate measures (AECM) for SNP management. This study aims to assess acceptability of contract attributes within AECM
Background. Pain is common in Parkinson's disease (PD) and impairs quality of life. The King's PD pain questionnaire (KPPQ) is a standardized, reliable, and valid self-administered questionnaire for screening of pain in PD. We developed a linguistically validated German version of the KPPQ and applied it to a cohort with fluctuating PD. Methods. The interculturally adapted German translation was p
Objectives: To explore the population-based risk factors for genital herpes in women and examine whether genital herpes occurs at higher rates in women diagnosed with cervical neoplasia and common urogenital infections. Methods: An open cohort study consisting of 4,097,075 women ≥15 years of age in Sweden (2002-2018). The outcome was genital herpes diagnosis. The predictor variables were sociodemo
opus: Op. 91bsubtitle: Bossainstrumentation: trumpet, brass quintetdedicated to: Håkan Hardenbergercommissioner: gift for Håkan's 50th birthday from the composer
Snowpack atop sea ice plays a vital role in the Arctic heat and energy balance by reducing the energy transfer between the atmosphere and the ocean. This study presents an improved snow depth retrieval model over Arctic multiyear ice (MYI) from the Microwave Radiometer Imager (MWRI) data of the Fengyun-3 (FY-3) series satellites using the optimal machine learning approach identified. Validation ag
Background: Pain is one of the most frequently reported symptoms and often one of the first subjective symptoms in patients with systemic lupus erythematosus (SLE). A previous study indicated that most patients with SLE reported low levels of SLE-related pain. However, a subgroup of patients reported high levels of pain ≥40 mm (0-100 mm) and had a substantial symptom burden in terms of fatigue, an
roduction of biomass for bioenergy on marginal land has been promoted to decrease the use of non-renewable energy without competing with food production. Previous estimates of marginal land and abandoned farmland in Sweden available for bioenergy production are based on general statistics and assumptions but lack in-depth analyses of potential alternative land-use values. Easily accessible public
Alexander disease (AxD) is a rare and severe neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP). While the exact disease mechanism remains unknown, previous studies suggest that mutant GFAP influences many cellular processes, including cytoskeleton stability, mechanosensing, metabolism, and proteasome function. While most studies have primarily focused on GFAP
Purpose: COVID-19 has profoundly shaped human interactions, and, within public healthcare systems, care relations. Through the lens of social suffering, this study explores how employee innovation is shaped by the pandemic crisis and different managerial approaches in the context of public geriatric care in Northeast Italy. Design/methodology/approach: This study adopts a qualitative methodology.
Background: Cardiac allograft vasculopathy is characterized by increased coronary intimal thickness and is a leading cause of death in heart transplant (HTx) recipients despite the routine use of statins. The experience with inhibitors of proprotein convertase subtilisin-kexin type 9 in HTx recipients is limited. Our hypothesis was that lowering cholesterol with the proprotein convertase subtilisi
The possibilities of generative artificial intelligence (GenAI) are both exciting and potentially concerning in many aspects of higher education. One concern may be that the increased use of GenAI tools exacerbates and perpetuates structural inequities due to the material used to train these tools, counteracting efforts to build inclusive learning communities. In this chapter, we consider how univ
Protein dynamics are essential to biological function, and methods to determine such structural rearrangements constitute a frontier in structural biology. Synchrotron radiation can track real-time protein dynamics, but accessibility to dedicated high-flux single X-ray pulse time-resolved beamlines is scarce and protein targets amendable to such characterization are limited. These limitations can
