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Duplication of PLP1 (proteolipid protein gene 1) and the subsequent overexpression of the myelin protein PLP (also known as DM20) in oligodendrocytes is the most frequent cause of Pelizaeus-Merzbacher disease (PMD), a fatal leukodystrophy without therapeutic options. PLP binds cholesterol and is contained within membrane lipid raft microdomains. Cholesterol availability is the rate-limiting factor
From back cover: "A smart, incisive toolkit for understanding how the framing of information influences the way we see the world.In today's chaotic media landscape, working out who and what to believe is a daunting task. Lies and misinformation are only part of the problem - often the way a story is presented has just as much effect on us as what the story is.In Framing, sociologist Mikael Klintma
The following sections are included:OverviewInitiation of particles in convectionGrowth of particles in convectionRepresentation of microphysics in mass-flux convection schemes of large-scale modelsSummary
Non-revenue water due to pipe leakages presents a significant global challenge, impacting both the economy and environmental sustainability. The current approach to pipe management for water utilities in Sweden is mainly reactive; leaks are repaired when detected, sometimes with large costs if the leakage is extensive and critical. With this study, we want to focus on proactive pipe network manage
The European Union (EU) and the EU member states have adopted a number of policies that can support circular economy developments in the electrical and electronic equipment (EEE) sector, and additional policies have been proposed. The policies include the new Ecodesign Regulation and a new Battery Regulation, and forthcoming rules related to durability and repairability of mobile phones and tablet
Background: Fatigue is the most debilitating symptom in patients with multiple sclerosis (MS). Natalizumab and rituximab are the most used MS disease modifying therapies in Sweden, but comparative data on the effect on fatigue is sparse. Objective: Primary objective was to compare fatigue levels between patients on natalizumab and rituximab. As secondary objective, we assessed processing speed, an
Chirality is omnipresent in the living world. As biomimetic nanotechnology and self-assembly advance, they too need chirality. Accordingly, there is a pressing need to develop general methods to characterize chiral building blocks at the nanoscale in liquids such as water─the medium of life. Here, we demonstrate the chiroptical second-harmonic Tyndall scattering effect. The effect was observed in
The magnetic Laplacian with a step magnetic field has been intensively studied during the last years. We adapt the construction introduced by Bonnaillie-Noël et al. [Bull. London Math. Soc. 56, 2529 (2024)] to prove the existence of bound states of a new effective operator involving a magnetic step field on a domain with an almost flat magnetic barrier. This result emphasizes the fact that even a
Objective: To assess comparative effectiveness, safety, and tolerability of off-label rituximab, compared with frequently used therapies approved for multiple sclerosis (MS). Methods: A Swedish cohort study of persons with relapsing–remitting MS, age 18 to 75 years at inclusion and with a first therapy start or a first therapy switch between 2011 and 2018. Low-dose rituximab was compared with MS-a
When people talk about kinship systems, they often use co-speech gestures and other representations to elaborate. This paper investigates such polysemiotic (spoken, gestured, and drawn) descriptions of kinship relations, to see if they display recurring patterns of conventionalization that capture specific social structures. We present an exploratory hypothesis-generating study of descriptions pro
Identification and characterization of CD8+ T-cells is important to determine their role in protecting and clearing viral infections. Here we provide details of the peptide-MHC (pMHC) tetramers-based approach to identify antigen-specific T-cells in human and murine samples. This method provides ex vivo quantifica-tion and functional characterization of T-cells reactive to specific viral antigens d
The operational map of the H3 Mach 6 blowdown wind tunnel, at the von Karman Institute for Fluid Dynamics (VKI), is extended towards lower Mach numbers with a new axisymmetric contoured nozzle to achieve Mach 5 testing conditions. Following the design, manufacturing, instrumentation and integration of the Mach 5 nozzle, an extensive commissioning campaign is initiated. The flow investigations rely
Incretin-based therapies are highly successful in combatting obesity and type 2 diabetes1. Yet both activation and inhibition of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in combination with glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) activation have resulted in similar clinical outcomes, as demonstrated by the GIPR–GLP-1R co-agonist tirzepatide2 and AMG-133 (ref
