Filetype
The cell cycle consists of an initial growth phase (G1), DNA replication (S), a gap phase (G2), and mitosis (M), after which the cell may differentiate or enter the resting state (G0). The cycle is driven by a number of positive and negative regulatory phosphorylation and dephosphorylation events, involving protein kinases, protein phosphatases, cyclins, cyclin-dependent kinases, and cyclin-depend
Although the involvement of the tumor suppressor gene p53 in normal hematopoiesis is uncertain, it can give rise to differentiation signals in leukemic cells. It is not clear, however, whether differentiation merely is a consequence of the ability of p53 to arrest cell proliferation or whether hitherto unknown molecular mechanisms are responsible for the p53-mediated differentiation. To further ex
Acute myeloid leukemia (AML) is characterized by a differentiation block leading to accumulation of immature cells. Chromosomal translocations in AML affect transcription factors that are involved in regulation of myeloid differentiation. Aberrant expression of these factors interferes with differentiation events and has a role in the pathogenesis of AML through superactivation or (dominant negati
Blodbildning är en biologisk massproduktion som styrs av cytokiner. Dessa utgör en mångfald av peptidkedjor, som tjänar som överlevnads-, tillväxt- och utmognadsfaktorer och som dessutom stimulerar funktionellt aktiva blodceller. Cytokiner används t ex för att mina cytostatikainducerad neutropeni, för att avkorta aplasiperioden efter benmärgstransplantation och för att behandla kroniska neutropeniHaematopoiesis is regulated by unrelated, pleiotropic, and diverse regulatory molecules, cytokines, whose membrane receptors are related and restricted to a few families manifesting sequence homology. Most members of the cytokine receptor family which lack tyrosine kinase activity are composed of multiple chains. An accessory signal transducer can be shared by members of the receptor family. Cytok
The cDNA of the human wild-type p53 tumor suppressor gene was constitutively overexpressed in the leukemic cell line K562 (which lacks detectable amounts of p53 protein) in order to investigate the consequences for growth and differentiation. Several stable clones were established by transfection of the expression vector pc53SN3. Expression of p53 protein was characterized by biosynthetic labeling
Anthropogenic pollution is a pervasive feature of urbanisation, reaching into ecosystems worldwide and posing novel challenges to wildlife. Not surprisingly, differences in behaviour, and physiology, have been found between urban and rural populations. Most studies on anthropogenic impacts have so far either used a dichotomous approach, comparing urban-rural sites, or investigated impacts of just
The fragmentation rate function connects the fundamental drop breakup process with the resulting drop size distribution and is central to understanding or modeling emulsification processes. There is a large interest in being able to reliably measure it from an emulsification experiment, both for generating data for validating theoretical fragmentation rate function suggestions and as a tool for st
Diabetes is a complex and multifactorial disease that affects millions of people worldwide, reducing the quality of life significantly, and results in grave consequences for our health care system. In type 2 diabetes (T2D), the lack of β-cell compensatory mechanisms overcoming peripherally developed insulin resistance is a paramount factor leading to disturbed blood glucose levels and lipid metabo
