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In the photoreceptors of the retina, the second-messenger molecule cyclic guanosine monophosphate (cGMP) occupies centre stage in the phototransduction cascade. Remarkably, cGMP is also involved in hereditary photoreceptor degeneration caused by a variety of different genetic insults. This provides an entry point for the development of inhibitory cGMP analogues for a mutation-independent treatment
The metaphor of a potential epigenetic differentiation landscape broadly suggests that during differentiation a stem cell approaches a stable equilibrium state from a higher free energy towards a stable equilibrium state which represents the final cell type. It has been conjectured that there is an analogy to the concept of entropy in statistical mechanics. In this context, in the undifferentiated
In this comment on Francesco Guala’s Understanding Institutions, I express my admiration for the book but I also raise some critical criticisms: His general account of institutions as rules-in-equilibrium seems to get their ontology wrong by disregarding their material side - their concrete realizations. It also diregards social institutions whose rules are not (and are not meant to be) in equilib
STUDY QUESTION: Are chemerin levels different in subfertile men compared to men from the general population, and how does chemerin relate to reproductive hormonal status? SUMMARY ANSWER: Chemerin is negatively associated to LH, SHBG and estradiol and lower levels of chemerin are detected among subfertile men compared to controls. WHAT IS KNOWN ALREADY: Adipokines have pleiotropic effects on tissue
Apolipoprotein A-I (ApoA-I)-related amyloidosis is a rare disease caused by missense mutations in the APOA1 gene. These mutations lead to protein aggregation and abnormal accumulation of ApoA-I amyloid fibrils in heart, liver, kidneys, skin, nerves, ovaries, or testes. Consequently, the carriers are at risk of single- or multi-organ failure and of need of organ transplantation. Understanding the b
The impact of commuting on health depends, in part, on the mode of travel. A sizeable body of literature addresses associations between mode choice and health status, but little is known about how a person's health affects commuting mode choice. Stress, exhaustion and obesity are threats to public health that increase in modern societies. Understanding how these concerns impact mode choice is impo
Background: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors. Materials and methods: This is a cross-sectional analysis of baseline data from a randomized controlle
Objectives: Counts of missing teeth or measures of incident tooth loss are gaining attention as a simple way to measure dental status in large population studies. We explore the meaning of these metrics and how missing teeth might influence other measures of dental status. Methods: An observational study was performed in 2 contrasting adult populations. In total, 62 522 adult participants were ava
Recension av Westerlund, Jenny (2017). Barn av vår tid. Ett nytt sätt att möta barn med problemskapande beteende i skolan. Lund: Studentlitteratur.
Migratory songbirds are guided by an endogenous programme during their first migration, encoding timing of migration, distance and direction. To successfully perform migration, birds have evolved phenotypic adaptations for flight, fuelling and navigation. Migratory distance in different species of birds is encoded as a period of expressed migratory restlessness, for which the length is correlated
Within the hematopoietic system, the Notch pathway is critical for promoting thymic T cell development and suppressing the B and myeloid lineage fates; however, its impact on NK lymphopoiesis is less understood. To study the role of Notch during NK cell development in vivo, we investigated different NK cell compartments and function in Rbp-Jkfl/flVav-Cretg/+ mice, in which Rbp-Jk, the major transc
INTRODUCTION:: Understanding medical information and self-management ability is vital for good quality of life among transplant recipients. However, health literacy (HL) has never been investigated among lung transplant recipients. OBJECTIVE:: This study investigated HL among Swedish lung transplant recipients 1 to 5 years after lung transplantation in relation to recovery, fatigue, adherence, cog
This paper presents existence theories for several families of axisymmetric solitary waves on the surface of an otherwise cylindrical ferrofluid jet surrounding a stationary metal rod. The ferrofluid, which is governed by a general (nonlinear) magnetisation law, is subject to an azimuthal magnetic field generated by an electric current flowing along the rod. The ferrohydrodynamic problem for axisy
In recent years the availability of digital reproductions of present and past images has increased significantly, in many ways facilitating teaching in art history. Students of art history of today live in a society dominated by visual media and are supposed to be particularly adept to communicate through digital media. This seems as an ideal situation for teaching art history, and the use of draw
Pyranose dehydrogenase (PDH) is a quinone-dependent extracellular flavoglycoprotein mainly produced by litter-decomposing fungi and contributes to the degradation of lignocellulose. PDH in terms of structure and catalytic features pertains to the glucose methanol-choline oxidoreductase family and oxidizes a wide substrate range of aldopyranoses including hexoses, pentoses, disaccharides and oligos
On St. Paul Island, a remnant of the Bering Land Bridge, woolly mammoths persisted until 5,600 yr BP with no known predators or competitors, providing a natural system for studying hypothesized environmental drivers of extinction. These include overheating due to rising temperatures, starvation, and drought. Here, we test these hypotheses using Niche Mapper and LPJ-GUESS to mechanistically estimat
The objective is to systematically review the literature on economic evaluations of pharmacological treatments of dementia disorders. A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and empirical evidence (costs, effects, incremental cost-effectiveness ratio) and we a
his study is intended to demonstrate the significant shifts in DOM concentration with space and time within and across inland waters (lakes), which can be acquired by the analysis of DOM concentration using Sentinel-2A imagery. Using a remote sensing method (based on Sentinel-2A data) to evaluate DOM quantity or concentration in freshwater (lakes), optical properties shifts of CDOM of spatial and
In theory, the use of collateral in credit contracting should mitigate the information problems that are widely held to be the primary cause of credit rationing. However, direct empirical evidence of the link between collateral use and credit rationing is scant. This paper examines the relationship between collateral and credit rationing using survey data that provides clean measures of quantity a
Despite the fact that Cesarean section (C-section) is the most commonly performed surgery in a number of industrialized countries, little is known about the long-term consequences for the mothers and children involved. In this study, I use a sample of high-risk births—namely, breech births, in which the fetus is presented with its head upward instead of downward—to study the causal effect of C-sec
