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Historically, lethal exsanguinations and severe infections have been two major causes of maternal death. Gene mutations that lower the risk of profuse hemorrhage or severe infections would give a survival advantage. A single mutation of coagulation factor V, known as FV Leiden (FVL), can be such a beneficial mutation. FVL is common among Caucasians and today confers an increased risk of thromboemb
Discussion of the why and how of keeping up the agnostic (not atheistic) character of academic exegesis, and the effects of having an insider or outsider perspective (bias) on the matters explored in this discipline.
Abstract in French En Suède comme dans d’autres pays européns, les pratiques de l’organisation de l’espace connaissent actuellement des transformations radicales, dues au développement des technologies (principalement dans les infrastructures, les transports et la communication), àla mondialisation de l’éonomie et àl’intération accrue du pays dans l’Union europénne. Le regard portésur les possibil
Recent studies have revealed a close relationship between inflammatory and metabolic pathways, and inflammation is now recognized to have a major role in obesity and metabolic diseases such as insulin resistance and atherosclerosis. The human body is home to a large number of distinct microbial communities, with the densest population in the distal gut (the gut microbiota). Bacteria have long been
Multiple myeloma (MM) is a disease of immunoglobulin producing plasma cells which reside mainly in the bone marrow. Family members of MM patients are at a risk of MM but whether other malignancies are in excess in family members is not established and is the aim of this study. MM patients (24,137) were identified from the Swedish Cancer Registry from years 1958-2012. Relative risks (RRs) were calc
Multiple genetic hits are detected in patients with acute myeloid leukemia (AML). To investigate this further, we developed a tetracycline-inducible mouse model of AML, in which the initial transforming event, overexpression of HOXA10, can be eliminated. Continuous overexpression of HOXA10 is required to generate AML in primary recipient mice, but is not essential for maintenance of the leukemia.
Abstract in Uncoded languages A kooperatív játékelmélet egyik legjelentősebb eredménye, hogy számos konfliktushelyzetben stabil megoldást nyújt. Ez azonban csak statikus és determinisztikus környezetben alkalmazható jól. Most megmutatjuk a mag egy olyan kiterjesztését, a gyenge szekvenciális magot, mely képes valós, dinamikus, bizonytalan környezetben is eligazítást nyújtani. A megoldást a csődját
Previously, a positive effect of exercise on cartilage structure was indicated with delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC). However, in that study only one full-thickness region of interest (ROI) in the medial femoral condyle was analyzed.
Objectives: The aim of this study was to explore nurses' experience of strain in dementia care. Method: Focus groups were held with 35 nurses in Sweden, Australia and UK, who care for people with dementia. The discussions were tape-recorded and analysed using qualitative content analysis. Results: The nurses described the complexity of their situation and referred to environmental factors such as
This paper is about automatic classification of dialect and accent type in Swedish. We used disyllabic words from the speech material of the Swedia 2000 dialect project in order to build a statistical prediction model. The model uses different parameters extracted from F0 contours of the words. Classification of dialect is performed for the features 'province' and 'village', whereas classification
BACKGROUND: A flow cytometric method for detection of low levels of A/B antigen had been developed previously in our laboratory. The aim of this study was to investigate if this approach could be utilized to characterize different ABO subgroups and constitute a useful tool in a reference laboratory. STUDY DESIGN AND METHODS: Blood samples causing ABO discrepancies (n = 94) by routine serology were
Controlled resistive loads can contribute to damping of electro-mechanical oscillations. This paper presents an on-off damping controller for a single machine system. It was used at a field test in Southern Sweden to damp oscillations of a 0.9 MW hydro power generator. The controller used estimated machine frequency as input and controlled a 20 kW resistive load via thyristor switches. The field m
Abstract Objective: To evaluate long-run cost-effectiveness in a Swedish setting for liraglutide compared with sulphonylureas (glimepiride) or sitagliptin, all as add-on to metformin for patients with type 2 diabetes insufficiently controlled with metformin in monotherapy. Methods: The IHE Cohort Model of Type 2 Diabetes was used to evaluate clinical and economic outcomes from a societal perspecti
On the macro level, bankruptcies are an intrinsic part of market economies and result in restructurings of companies and markets. On the micro level, bankrupt entrepreneurs are temporarily excluded from the market and forced to reorganize their understanding of the market. While some seek their way back to entrepreneurship, others decide to find other means of living which may result in drainage o
Spinal deformities affect young individuals predominantly girls who are usually subjected to regular and intensive radiological investigation especially before and after corrective surgery. Optimisation of spine computed tomography (CT) and the implementation of the low-dose CT in the work-up of spinal deformities were presented. The presented low-dose CT here means providing the operating surgeon
