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Metformin is the first-line pharmacotherapy for managing type 2 diabetes (T2D). However, many patients with T2D do not respond to or tolerate metformin well. Currently, there are no phenotypes that successfully predict glycemic response to, or tolerance of, metformin. We explored whether blood-based epigenetic markers could discriminate metformin response and tolerance by analyzing genome-wide DNA
Partially premixed combustion (PPC) is one of the advanced combustion concepts that is being actively investigated. A joint experimental and numerical investigations were conducted to explore the effects of octane number and injection timing on the autoignition behaviour with primary reference fuel (PRF) and gasoline fuels under PPC mode in a light-duty DICI engine. In this study, the start of inj
CO2 is a greenhouse gas that is believed to be one of the main contributors to global warming. Recent studies show that a combination of methanol as a renewable fuel and advanced combustion concepts could be a promising future solution to alleviate this problem. However, high unburned hydrocarbon (UHC) and carbon monoxide (CO) emissions can be stated as the main drawback in low load operations whe
Children with Down syndrome (DS) using intensive computer-based phonics (GraphoGame, GG) were studied. The children's independence and improvement in phonological processing, letter knowledge, word decoding, and reading strategies were investigated. Seventeen children (5-16 years) with DS participated in a crossover design through 8 weeks (one period), with three test sessions separated by 4 weeks
This dissertation concerns a legal development that is currently taking place in Sweden due to its membership in the European Union (EU). It analyses the impact of the EU legal principle on abuse of law (the abuse principle). This principle has been developed gradually under long time in EU law and clarifying rulings from the Court of Justice of the European Union (CJEU) on the general nature of t
A perspective paper about the Swedish ambulance services.
An optimal network design was carried out to prioritise the installation or refurbishment of greenhouse gas (GHG) monitoring stations around Africa. The network was optimised to reduce the uncertainty in emissions across three of the most important GHGs: CO2, CH4, and N2O. Optimal networks were derived using incremental optimisation of the percentage uncertainty reduction achieved by a Gaussian Ba
Evaluative neutralization implies rephrasing items such that it is less clear to the respondent what would be a desirable response in the given population. The current research compares evaluatively neutralized scales measuring the FFM model with standard counterparts. Study 1 reveals that evaluatively neutralized scales are less influenced by social desirability. Study 2 estimates higher-order fa
The research community recently proposed a low-temperature combustion (LTC) concept that can simultaneously reduce Nitrogen Oxides (NOx) and soot emissions while maintaining high engine efficiency. Given that diesel fuel is prone to preignition with early injection, gasoline-like fuel with high octane number is utilised to provide sufficient ignition delay and extend the load range. Understanding
