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Precision medicine has the potential to transform healthcare by moving from one-size-fits-all to personalised treatment and care. This transition has been greatly facilitated through new high-throughput sequencing technologies that can provide the unique molecular profile of each individual patient, along with the rapid development of targeted therapies directed to the Achilles heels of each disea
Tre hidtil upublicerede indskrifter fra omegnen af Vezirköprü, oldtidens NeoklaudiopolisDuring the spring campaign 2010 of the Nerik project of the Free University of Berlin, 2 severalunpublished inscriptions were recorded in the region around Vezirköprü (Samsun province),ancient Neoklaudiopolis. Among these were three funerary inscriptions preserved in their entirety.
To achieve global change in order to battle climate change, it is important that consumers all over the world actively engage in more sustainable consumption. This is particularly important in Asia where 90 percent of the global consumption growth will occur during the next decade. This chapter looks at two countries in Asia, Taiwan, and China, which share a similar culture and language, but diffe
Within recent years, a number of inscriptions have come to light in Vezirköprü (ancient Neapolis/Neoklaudiopolis/Andrapa) and its immediate environs. The district known as the Cumhuriyet Mahallesi immediately to the south of the present town centre has been especially rich in ancient remains, and many of these, along with spoils and inscriptions from other parts of the city, have now been brought
In an explorative manner, this article uses a data-driven digital history set-up to focus on how the Swedish Riksdag, its political parties and parliament members discussed media issues. By distant reading and topic modeling a dataset of more than 11,000 parliamentary minutes – approximately 400 million characters – the article gives a new perspective of Swedish media history in general and nation
Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) to glycerol and one fatty acid. Among the various MG species, MGL also degrades 2-arachidonoylglycerol, the most abundant endocannabinoid and potent activator of the cannabinoid receptors 1 and 2. We investigated the consequences of MGL deficiency on platelet function using systemic (Mgl-/-) and platelet-specific Mgl-deficient (platMgl-/
Much has been written about the risks posed by artificial intelligence (AI). This article is interested not only in what is known about these risks, but what remains unknown and how that unknowing is and should be approached. By reviewing and expanding on the scientific literature, it explores how social knowledge contributes to the understanding of AI and its regulatory challenges. The analysis i
In recent years, the global environmental science-policy interface has come to include a greater variety of knowledge. Social scientists have joined natural scientists at the policy table, and Indigenous and local knowledge is being taken ever more seriously. But this pluralisation raises political, normative, and epistemic challenges for environmental expert organisations, including with respect
Emerging evidence suggests differential effects of therapeutic antibiotics on infant T cell responses to pathogens. In this study, we explored the impact of the treatment of mouse infants with amoxicillin and the human milk-derived antimicrobial HAMLET (human alpha-lactalbumin made lethal to tumor cells) on T cell responses to Streptococcus pneumoniae. Lung cells and splenocytes were isolated fr
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where it is highly toxic for pericytes, mural cells that have contractile properties and regulate capillary
