Background: Both caveolin-1 (CAV1) and insulin-like growth factor bindings protein 7 (IGFBP7) have been linked to angiogenesis, insulin-like growth factor (IGF) receptor 1 (IGF-1R) signaling, and the tumor microenvironment. However, CAV1 and IGFBP7 have not yet been adequately characterized and investigated as potential prognostic or treatment-predictive biomarkers at the genomic, transcriptomic,

To stay competitive in today’s environment, characterized by changing customer requirements, digitalization, new technologies, etc., companies must deliver fast and continuous innovation. Manufacturing companies have therefore started to launch large-scale agile transformation initiatives. A specificity of manufacturing companies is their need for deeply specialized organizational units. Knowledge

When a course is designed, it is common to do it for a typical group of students, considered to represent “the majority”, the “norm” or the “average”. The concept of “edges” challenges this view: given the multiple dimensions that teaching and learning encompass, there will always be students who do not belong to a norm and will end up on an edge if they are not included in the course design. In t

All people are different. All teachers are different. All students are different. They have different life situations, different study situations, and different preferences, conditions, and abilities. How can we take this diversity into account when we plan our teaching and exams? What situations should we prepare for? How can we help students focus on their learning and not on unnecessary obstacl

The manual execution of failure mode and effects analysis (FMEA) is time-consuming and error-prone. This article presents an approach in which large language models (LLMs) are integrated into FMEA. LLMs improve and accelerate FMEA with human in the loop. The discussion looks at software tools for FMEA and emphasizes that the tools must be tailored to the needs of the company. Our framework combine

Oligomeric assemblies consisting of only a few protein subunits are key species in the cytotoxicity of neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. Their lifetime in solution and abundance, governed by the balance of their sources and sinks, are thus important determinants of disease. While significant advances have been made in elucidating the processes that govern o

The turn to performativity in the social sciences has spawned a new wave of scholarship that considers tourism as a performative process. However, the manner through which scholars understand tourism as performative drama is limiting. A fundamental critique of dramaturgy stems from its inability to account for performance as a chain of emergent social processes. Using the case of free walking tour

The key to understanding any social phenomenon is to follow how actors tread the social landscape and describe how they form groups, fuse meanings, and create associations with different frames. In this paper, I employ Bruno Latour’s reconceptualization of assemblage to trace how NGOs and other actors create assemblages by fusing or defusing dog-eating with discourses on dirt, epidemic, and human

This paper explores how dog-meat consumption in the Philippines serves as an empty icon for varied social discourses. By utilizing structural hermeneutics of the Strong Program and Ernesto Laclau's concept of empty signification, this research locates dog and dog eating as empty signifiers that function as a battleground for competing discourses about Philippine identity, tradition and culture. Th

This article presents the results of groundwater monitoring over a period of six years and the interpretation of these results by a reactive transport model, following an In Situ Recovery (ISR) test on the Dulaan Uul uranium deposit in Mongolia. An environmental monitoring survey was set up using 17 piezometers, from which it has been possible to describe the changes in the water composition befor

BACKGROUND/PURPOSE: Non-resuscitation fluids constitute the majority of fluid administered for septic shock patients in the intensive care unit (ICU). This multicentre, randomized, feasibility trial was conducted to test the hypothesis that a restrictive protocol targeting non-resuscitation fluids reduces the overall volume administered compared with usual care.METHODS: Adults with septic shock in

Background:Rectal cancer patients commonly benefit from neoadjuvant therapy before resection surgery. For these patients, an elective ostomy diversion is frequently considered, despite the absence of conclusive evidence when a diversion is advantageous. This is a retrospective observational single-center study on a 4-year consecutive rectal cancer cohort undergoing neoadjuvant therapy, aiming at i

To reach the goals of the Paris Agreement, global emissions should be reduced to net zero by mid-century. The steel sector is an emission-intensive industrial subsector where low-carbon production routes are emerging, and recent studies have shown that rapid decarbonization of the sector is technically possible. However, several barriers block the sector-wide diffusion of low-carbon steelmaking. I

Background and objective: We investigated whether adding 4Kscore as a reflex test to prostate-specific antigen (PSA) could improve the screening algorithm for prostate cancer (PC). Methods: In the GÖTEBORG-2 PC screening trial, 38 000men (50–60 yr) were invited to PSA testing and, if elevated, followed by magnetic resonance imaging (MRI). For 571 men with PSA ≥3.0 ng/ml and evaluable outcomes, 4Ks

The article examines the formal process of ‘ethical clearance’ for social science research at a large university and illuminates how it functions to undermine its stated purpose. We find that rather than promoting ethical standards, the bureaucratic process creates negative and cynical attitudes and game playing. For almost all participants, the entire procedure is counterproductive and experience