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Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses. It is unlikely that prior therapy is solely responsible for SPC risk. To investigate risk of SPC after diagnosis of non-Hodgkin lymphoma (NHL) and 10 of its subtypes we conducted a novel bidirectional analysis, SPCs after NHL and NHL as SPC. Using the Swedish Family-Cancer Database, we identified 19,833 ind

The sediment succession at Skilvika, west Svalbard, represents one of the key stratigraphic records of the Late Quaternary palaeoenvironments and glaciation history of the Svalbard/Barents Sea area. A formation of raised marine sediments, interfingering with and capped by glacial deposits of local origin, have previously been assumed to be of an Early Weichselian age, likely marine isotope stage (

Purpose: To assess mean change in visual acuity (VA) overall and stratified by baseline VA after 1 and 2 years’ treatment with aflibercept in a real-life setting. Methods: This was an observational cohort study using nationwide data from the Swedish Macula Register. Treatment-naïve patient eyes with wet age-related macular degeneration and prescribed aflibercept from January 2013 to December 2014

Aims: Identification and treatment of the rupture prone atherosclerotic plaque remains a challenge for reducing the burden of cardiovascular disease. The interconnection of metabolic and inflammatory processes in rupture prone plaques is poorly understood. Herein, we investigate associations between metabolite profiles, inflammatory mediators and vulnerability in carotid atherosclerotic plaques.Me

OBJECTIVE: Cardiovascular disease (CVD) risk prediction represents an increasing clinical challenge in the treatment of diabetes. We used a panel of vascular imaging, functional assessments, and biomarkers reflecting different disease mechanisms to identify clinically useful markers of risk for cardiovascular (CV) events in subjects with type 2 diabetes (T2D) with or without manifest CVD.RESEARCH

This article casts light on the development of new regional industrial paths. We explore factors explaining why regional industries with similar early path development trajectories may exhibit diverging outcomes in the longer run and pay particular attention to the role of ‘outsiders’ in the initiation and further development of regional industrial paths. Drawing on a comparative case study of IT

Biomass production efficiency (BPE), the ratio of biomass production to photosynthesis, varies greatly among ecosystems and typically increases with increasing nutrient availability. Reduced carbon partitioning to mycorrhizal fungi (i.e., per unit photosynthesis) is the hypothesized underlying mechanism, as mycorrhizal abundance and plant dependence on these symbionts typically decrease with incre

Ischemic stroke is the second most common cause of death worldwide and a major cause of disability. It takes place when the brain does not receive sufficient blood supply due to the blood clot in the vessels or narrowing of vessels’ inner space due to accumulation of fat products. Apart from thrombolysis (dissolving of blood clot) and thrombectomy (surgical removal of blood clot or widening of ves

Purpose: The aim of this study was to gain a deeper understanding of how children living in two homes after parents' separation experience their everyday lives. Design and Methods: An inductive qualitative design was chosen for the study using a hermeneutic phenomenological approach. Twelve children aged 10–13 years, and living in two homes, were interviewed. The data analysis used the four fundam

Background: Criteria for electrocardiographic detection of acute myocardial ischemia recommended by the Consensus Document of ESC/ACCF/AHA/WHF consist of two parts: The ST elevation myocardial infarction (STEMI) criteria based on ST elevation (ST↑) in 10 pairs of contiguous leads and the other on ST depression (ST↓) in the same 10 contiguous pairs. Our aim was to assess sensitivity (SE) and specif

A pocket cavity is generated at the junction position of the Low Pressure Turbine (LPT) and the Outlet Guide Vane (OGV) in the rear part of a gas turbine engine. The OGV mainly controls the exhaust flow exiting and provides structural strength of the main engine frame. In the present work, the effect the location of the pocket on the heat transfer of the endwall with a symmetrical vane is investig

In this work, we investigated muonic atoms and molecules from a quantum chemist's viewpoint by incorporating muons in the CASSCF model. With the aim of predicting muonic X-ray energies, primitive muonic basis sets were developed for a selection of elements. The basis sets were then used in CASSCF calculations of various atoms and molecules to calculate muonic excited states. We described the influ

This study used multi-date Landsat images to quantify mangrove cover changes in the whole of Bangladesh from 1976 to 2015. Images were pre-processed with an atmospheric correction using Dark Object Subtraction (DOS) and Relative Radiometric Normalization (RRN) using Pseudo-Invariant Features (PIFs). Land Use/Land Cover (LU/LC) classification map was generated using Maximum Likelihood (MaxLike) alg

3D Direct Numerical Simulations of propagation of a single-reaction wave in forced, statistically stationary, homogeneous, isotropic, and constant-density turbulence, which is not affected by the wave, are performed in order to investigate the influence of the wave development on scaling (power) exponents for the turbulent consumption velocity UT as a function of the rms turbulent velocity u′, lam

In the process of evaluating a parallel twin-turbine pulseturbocharged concept, the results considering the turbine operation clearly pointed towards an axial type of turbine. The radial turbine design first analyzed was seen to suffer from suboptimum values of flow coefficient, stage loading and blade-speed-ratio. Modifying the radial turbine by both assessing the influence of "trim" and inlet ti