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International Organizations
International organizations within and outside the United Nations system provide platforms for multilateral cooperation and give impulses for national policymaking to promote the implementation of the Sustainable Development Goals (SDGs). They set agendas, coordinate efforts across regions and countries, offer technical assistance and expertise, compile data and monitor progress, and raise awarene
Hydraulic Strategies Modulate Forest Productivity Responses to Hotter Droughts
Climate change, characterized by an increase in extreme climatic events, poses a significant threat to forest productivity worldwide, potentially compromising its critical role in regulating the global carbon cycle. The response of forest productivity to compound events, such as hotter droughts, can be strongly modulated by functional traits. Forests dominated by acquisitive tree species (prioriti
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Every 1,000 steps matter : incremental reductions in metabolic syndrome risk in Japanese office workers
Background: Several studies have investigated the association between metabolic syndrome (MetS) and physical activity (PA). However, further research is needed using objective measures of PA in free-living conditions, while also accounting for the time-variant nature of MetS. This study aimed to: (1) investigate the association between wearable device-measured step count and 5-year MetS incidence
Evaluating transformative policies in complex land-use systems
Policies that facilitate sustainability transformations require knowledge about the dynamics of complex socio-ecological systems, including biophysical mechanisms and diverse human-nature relationships. Such a comprehensive evidence base can only be built by integrating multiple types of knowledges. Ontology, epistemology, and semantics are a well-established terminology to structure and facilitat
Uncovering inequalities in greenspace access: an intersectional agenda for new sociological enquiry
Urbanisation, lifestyles and environmental degradation are associated with negative health and environmental outcomes through reducing greenspace access. These risks are not experienced equally across society. While useful concepts like ‘extinction of experience’ exist, sociological writing on these important themes remains underdeveloped. Using regression and analysis of variance with survey data
Impact of propylene glycol, menthol:thymol deep eutectic solvent, and their blends on the structure and molecular mobility of stratum corneum components
This study explored how propylene glycol (PG), menthol:thymol deep eutectic solvent (DES, molar ratio 6:4), and PG:DES blends modulate drug permeation by impacting the stratum corneum (SC). Porcine SC samples were exposed to PG, DES, and PG:DES blends with varying PG content (10 %, 50 %, or 90 %). The impact of these formulations on SC lipid extraction, lipid arrangement, and keratin's secondary s
Coping with global environmental change and the emotions it evokes : considering the role of empathy
Introduction: The climate and biodiversity crises are interconnected, unprecedented, existential threats that cause disturbing emotions, such as anxiety, grief, and anger. While there is increasing research about antecedents and outcomes of such eco-emotions, less is known about how to cope with them constructively, to benefit both mental health and pro-environmental action. Objectives: This study
Tidal interaction can stop galactic bars : On the LMC non-rotating bar
Context. The bar pattern speed of the LMC has been computed based on data from Gaia DR3 using three different methods. One method suggested that the LMC might be hosting a bar that barely rotates, and is slightly counter-rotating with respect to the disc of the LMC, with a pattern speed of Ωp = −1.0 ± 0.5 km s−1 kpc−1. Aims. We aim to confirm that tidal interactions might prevent the bar hosted by
Alterations in sample selection and low adherence to psychotherapy manuals lead to unexpected results. A letter to the Editors on “Randomized controlled trial for the Attempted Suicide Short Intervention Program (ASSIP) : An independent non-replication study”
The Swedish Society of Paediatric Infectious Diseases' 2025 Recommendations for the Initial Management of Suspected Paediatric Sepsis With or Without Shock
The Swedish Society of Paediatric Infectious Diseases worked with paediatric societies for emergency medicine, anaesthesia, and intensive care to produce the 2025 recommendations for the initial management of suspected sepsis. They cover 28 days of corrected age to 18 years, but exclude immunodeficiency, immunosuppression, and suspected meningitis. Suspicion of sepsis and sepsis-associated shock i
Phosphorylation of ITIM motifs drives the structural transition of indoleamine 2,3-dioxygenase 1 between enzymatic and non-enzymatic states
Indoleamine 2,3-dioxygenase 1 (IDO1) is the rate-limiting enzyme in tryptophan metabolism that plays a central role in immune regulation across a range of diseases, including cancer. Beyond its enzymatic role, IDO1 has a non-enzymatic function that remains poorly understood. This study explores how phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) modulates IDO1's structur
Belimumab concentrations and immunogenicity in relation to drug effectiveness and safety in SLE within a Swedish real-world setting
Objectives: Studies supporting therapeutic drug monitoring to biopharmaceuticals in SLE are scarce. We aimed to assess anti-drug antibody (ADA) occurrence in belimumab-treated SLE patients and associations between belimumab concentrations and clinical response, serological outcomes and adverse events. Methods. We included 100 patients treated with intravenous belimumab. Clinical data and biologica
Factors contributing to bladder fibrosis
Background: Bladder outlet obstruction, commonly resulting from benign prostatic hyperplasia or congenital urethral valves, is a prevalent cause of voiding dysfunction. This condition induces significant bladder hypertrophy, alters excitability, and increases residual urine. Obstruction has been extensively studied in experimental animal models using surgical obstruction. A frequent pathological e
Development of a new spatially complete and daily continuous lake surface water temperature dataset for Lake Vänern by fusing satellite and reanalysis products
Study region: Lake Vänern, the largest lake in the European Union, located in Sweden. Study focus: The study aimed to develop a spatially complete and temporally continuous lake surface water temperature (LSWT) dataset by fusing satellite remote sensing data with reanalysis products. Five satellite-derived LSWT products, including the Moderate Resolution Imaging Spectroradiometer (MODIS), were eva
How food disgust sensitivity influences perceptions of insects as food and feed : evidence from complementary quantitative and qualitative analysis
The role of food disgust on entamophagy acceptance is well established but further indepth analysis of how food disgust impacts other aspects that include a wider range of attitudes have been seldom investigated. The study employed a two-study mixed-methods approach to determine the impact of food disgust on consumer's perceptions of insects as food and feed. In study one, an online questionnaire
Assessment of nodal staging and risk factors for nodal involvement in gallbladder cancer
Background: Nodal assessment in gallbladder cancer remains challenging, particularly in incidental gallbladder cancer. This understages the number of patients with node-positive disease, resulting in prognostic inaccuracy and insufficient adjuvant treatment. This study aimed to identify risk factors for positive nodes in gallbladder cancer and to compare prognostic discrimination of available noda
Traumatic Exposure and PTSD Symptoms in a Sample From a Tertiary Pain Clinic
Background: Post-traumatic stress disorder (PTSD) is a significant psychiatric comorbidity in individuals with chronic pain. To date, the link between PTSD and chronic pain has mostly been described using the outdated DSM-IV PTSD criteria. Stronger evidence utilizing the updated DSM-5 criteria is needed to ensure comparability with earlier prevalence rates. Methods: This observational study report
Designing objects that are invisible to electromagnetic waves
This article shows that it is, in principle, possible to make a dielectric rod completely invisible to an incident electromagnetic plane wave of a given frequency. Students can derive the conditions that make the rod invisible if they understand the concept of plane waves, the boundary conditions for electric and magnetic fields, and the complex representation of electromagnetic fields. With acces
