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The purpose of this study was to measure the pharmacokinetics and tissue accumulation of N-acetylamino-3-chloro-N-(2-diethylamino-ethyl) benzamide (NACPA) after oral or intravenous administration at a single dose of 25 mg/kg to female W/Fu rats. The serum pharmacokinetics of NACPA were characterized by rapid absorption, distribution and elimination. However, in comparison with its parent compound,

OBJECTIVES: This study explored the subjective reactions and psychological test performance of smell-intolerant subjects during consecutive challenges to chemicals with contrasting neurotoxic properties. METHODS: Women with symptoms compatible with multiple chemical sensitivity (N=10) and healthy referents (N=20) were individually challenged in an exposure chamber. All the subjects attended two se

Declining biological production as a part of an ongoing land degradation process is considered a severe environmental problem in the dry northern and northwestern regions of China. The aim of this study is to develop and adapt a satellite data-driven gross primary production model called Lund University light use efficiency model (LULUE) to temperate conditions in order to map gross primary produc

A maximal symmetry group is a group of isomorphisms of a three-dimensional hyperbolic manifold of maximal order in relation to the volume of the manifold. In this paper we determine all maximal symmetry groups of the types PSL(2, q) and PGL(2, q). Depending on the prime p there are one or two such groups with q=pk and k always equals 1, 2 or 4.

Childhood sexual abuse has been shown to be common among adult women, 15-30% in prevalence studies, and among mentally ill women, 25-77%. These women often suffer from depression, anxiety, sexual and relationship problems. Suicide attempts and self-destructive behaviour are common. Within the Department of Psychiatry at Lund University Hospital, 45 women with experiences of childhood sexual abuse

BACKGROUND: Human glandular kallikrein 2 (hK2) and prostate-specific antigen (PSA) are members of an extensive kallikrein family of proteases. Both proteases are secreted as zymogens or proenzymes containing a seven amino acid propeptide that must be proteolytically removed for enzymatic activation. The physiological proteases that activate pro-hK2 and pro-PSA are not known. METHODS: The pro-hK2 p

Novel panning and screening methodology was devised to isolate high affinity human recombinant scFv antibody fragments with functionally associated properties in B lymphoma cells. The approach was used to generate a panel of apoptosis-inducing antibodies specific for antigens differentially expressed in B lymphoma vs. T leukaemia cells. The selections resulted in an antibody pool with near perfect

The hygroscopic properties of submicron soot particles during internal mixing with gaseous sulfuric acid have been investigated using a combined tandem differential mobility analyzer (TDMA) and differential mobility analyzer-aerosol particle mass analyzer (DMA-APM) technique. Fresh particles exhibit no change in mobility size and mass at subsaturated conditions, whereas particles exposed to gaseou

Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.

The influence of several operating parameters on the critical flux in the separation of lactic acid-producing bacteria from fermentation broth was studied using a ceramic microfiltration membrane equipped with a permeate pump. The operating parameters studied were crossflow velocity over the membrane, bacterial cell concentration, protein concentration, and pH. The influence of the isoelectric poi

This paper presents a model-based method to aid in the process validation for the purification of pharmaceutical drugs. The critical process parameters are identified by simulating process disturbances, and this information is then used to determine if the process control space is robust. Simulations are chosen to analyze the entire control space to also find nonlinearities and interaction effects

Transition probabilities based on sophisticated configuration-interaction wave functions have been obtained for transitions between the 20 lowest lying fine-structure levels of the 2s(2)2p, 2s2p2, 2p3, 2s(2)3s, 2s(2)3p and 2s(2)3d states of N III. The calculations were performed using the CIV3 code of Hibbert, and small empirical adjustments were introduced to the diagonal Hamiltonian matrix eleme

A new model for financial returns with time varying variance, skewness and kurtosis based on the Normal Inverse Gaussian (NIG) distribution is proposed. The new model and two previously suggested NIG models are evaluated by their Value at Risk (VaR) forecasts on a long series of daily Standard and Poor's 500 returns. All three models perform very well compared with extant models and clearly outper

Peptidergic neurotransmission is slow compared to that mediated by classical neurotransmitters. We have studied exocytotic membrane fusion and cargo release by simultaneous capacitance measurements and confocal imaging of single secretory vesicles in neuroendocrine cells. Depletion of the readily releasable pool (RRP) correlated with exocytosis of 10%-20% of the docked vesicles. Some remaining ves

Eighteen-year-old adolescents with alpha1-antitrypsin (alpha1AT) deficiency have mostly normal lung function tests. We hypothesized that compensatory increases in other protease inhibitors and/or a decreased leukocyte activity might favorably affect the protease/protease-inhibitor balance in alpha1AT-deficient adolescents. At the age of 18 y 46 PiZZ (severe deficiency), 22 PiSZ (moderate deficienc

Radiative lifetime measurements were performed by time-resolved laser-induced fluorescence (LIF) technique for eight even-parity levels of the astrophysically important ion Er+ over the energy range from 33753 to 55317 cm(-1). Free erbium ions were generated by a laser-induced plasma. A narrow bandwidth UV laser pulse (1 ns) was employed to populate selectively the short-lived upper levels, and th

No large randomized multicentre trial has evaluated the efficacy of radiofrequency ablation (RFA) vs. anti-arrhythmic drug (AAD) therapy as a first-line treatment of paroxysmal atrial fibrillation (AF). The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation (MANTRA-PAF) trial is a randomized, controlled, parallel group, multicentre study designed to test whether catheter-based RFA is supe