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Pulchrol (1) is a natural benzochromene isolated from the roots of Bourreria pulchra, shown to possess potent antiparasitic activity towards both Leishmania and Trypanozoma species. As it is not understood which molecular features of 1 are important for the antiparasitic activity, several analogues were synthesized and assayed. The ultimate goal is to understand the structure-activity relationship
Hybrid anisotropic microgels were synthesised using mesoporous silica as core particles. By finely controlling the synthesis conditions, the latter can be obtained with different shapes such as platelets, primary particles or rods. Using the core particles as seeds for precipitation polymerisation, a crosslinked poly(N-isopropylacrylamide) (PNIPAM) microgel shell could be grown at the surface, con
Assessments of long-term changes of air quality and global radiative forcing at a large scale heavily rely on satellite aerosol optical depth (AOD) datasets, particularly their temporal binning products. Although some attempts focusing on the validation of long-term satellite AOD have been conducted, there is still a lack of comprehensive quantification and understanding of the representativeness
Large carnivores are prioritized in conservation, but their co-occurrence with humans and domestic animals can generate conflict. Interventions preventing carnivore attacks are central to carnivore conservation, but are only effective if implemented. This study investigates drivers of the intention to use interventions among animal owners in Sweden based on the Theory of Planned Behavior, extended
Cancer stem cells from oropharyngeal squamous cell carcinoma (OPSCC) have the ability to self-renew and differentiate into heterogeneous three-dimensional structures carrying features of tumor cells. Here, we describe a simple and label-free method for generating tumor organoids, and imaging them using live digital holographic microscopy (DHM) on the basis of the phase shift caused by light passin
The oral glucose tolerance test (OGTT) is used to diagnose gestational and other types of diabetes. We examined metabolite changes during an OGTT, and how a comprehensive diet and physical activity intervention may influence these changes in a population of overweight/obese Hispanic pregnant women. Integration of changes in metabolites during an OGTT may help us gain preliminary insights into how
BACKGROUND: Since screening programs identify only a small proportion of the population as eligible for an intervention, genomic prediction of heritable risk factors could decrease the number needing to be screened by removing individuals at low genetic risk. We therefore tested whether a polygenic risk score for heel quantitative ultrasound speed of sound (SOS)-a heritable risk factor for osteopo
Iterative learning control (ILC) is an approach to improve the performance of a system that repeats the sameoperation. In this paper, we apply the theory of pseudospectra to transient analysis of ILC. The focus of thispaper is on frequency-domain analysis of filter-based ILC. Moreover, the effect of finite trial length on thetransient growth is discussed.
Imaging beta cells is a key step towards understanding islet transplantation. Although different imaging platforms for the recording of beta cell biology have been developed and utilized in vivo, they are limited in terms of allowing single cell resolution and continuous longitudinal recordings. Because of the transparency of the cornea, the anterior chamber of the eye (ACE) in mice is well suited
We show that the structured singular value of a real matrix with respect to five full complex uncertainty blocks equals its convex upper bound. This is done by formulating the equality conditions as a feasibility SDP and invoking a result on the existence of a low-rank solution. A counterexample is given for the case of six uncertainty blocks. Known results are also revisited using the proposed ap
BACKGROUND: Multiple patient and clinical characteristics contribute to the variable outcome of spinal anesthesia (SPA). Acute reduction of cerebrospinal fluid (CSF) volume may alter the effect of SPA. The objective of the present study was to test if aspiration of 10 mL CSF immediately prior to SPA is associated with higher extent of sensory block. METHODS: Interventional cohort study. One hundre
Preeclampsia is one of the most common causes of perinatal and maternal morbidity/ mortality. One suggested environmental risk factor is exposure to endocrine-disrupting pollutants such as per-and polyfluoroalkyl substances (PFAS). The present case-control study in southern Sweden aims to investigate the hypothesized association between serum concentrations of PFAS in early pregnancy and the risk
Background: Cardiovascular autonomic dysfunction is a multifactorial disorder manifested as orthostatic hypotension (OH) and postural orthostatic tachycardia syndrome (POTS). OH has been associated with an increased risk of cardiovascular disease (CVD), and the underlying mechanisms are not fully understood and explored.Aims and methods: Project I: We aimed to discover protein biomarkers related t
The luminescence properties of ScxY1-xPO4:Eu3+ solid solutions have been studied under excitation by synchrotron radiation in the energy range of 4.5-50 eV. The luminescence originating from three different types of emission centers was observed, and the origin of the emission centers was determined. The light output of ScxY1-xPO4:Eu3+ was shown to depend non-linearly on the ratio of Sc and Y cati
Data and literature related to water quality as well as nutrient loads were used to evaluate the Changjiang River (also Yangtze or Yangzi) Basin with respect to its hydrological regime, sediment transport, and eutrophication status. Waterbodies exhibited different eutrophic degrees following the ranking order of river < reservoir < lake. Most of the eutrophic lakes and reservoirs distributed in th
This article empirically analyses the relationship between nationalism and regional economic integration in the Kingdom of Yugoslavia between the First and the Second World War. It argues that prevailing nationalism had a negative impact on the economic integration of the regions within the Kingdom and further contributed to the political disintegration of the Kingdom. The analysis implies that th
Precipitation phase determination is a known source of uncertainty in surface-based hydrological, ecological, safety, and climate models. This is primarily due to the surface precipitation phase being a result of cloud and atmospheric properties not measured at surface meteorological or hydrological stations. Adding to the uncertainty, many conceptual hydrological models use a 24-h average air tem
Regions with a large percentage of precipitation occurring near freezing experience high percentages (>10%) of misclassified precipitation events (rain versus snow) and necessitate efforts to improve precipitation phase determination schemes through the use of more accurate surface air temperature thresholds (Trs). Meteorological data from 169 sites in Scandinavia were used to test the applicabili
Both flood magnitude and frequency might change under the changing environment. In this study, a procedure combining statistical methods, flood frequency analysis and attribution analysis was proposed to investigate the response of floods to urbanization and precipitation change in the Qinhuai River Basin, an urbanized basin located in Southeast China, over the period from 1986 to 2013. The Mann–K
