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Histones become present extracellularly in the airways as a consequence of celldeathoccurring during inflammation, for example in ARDS, COPD, and cysticfibrosis (CF). Extracellular histones bind Toll-like receptors and thereby promoteinflammation. In addition, due to their highly cationic nature, histones are highlycytotoxic. Thus, mechanisms controlling the activities of extracellular histones ar

Acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) are characterized by dysregulated inflammation of the airways. The increased influx of immune cells and the accumulation of cytokines lead to cell death, tissue destruction and impaired pulmonary function. Intracellular proteins like histones and granule proteins of neutrophils, DNA f

Konceptet gap-mending är ett analytiskt verktyg för att ge socialarbetare, lärare och forskare i socialt arbete stöd för att reflektera över faktorer i deras arbetssätt som förstärker och upprätthåller klyftor mellan socialarbetare och olika brukargrupper. I artikeln ges, med utgångspunkt i teorier om makt och erkännande, en teoretisk bakgrund till hur klyftor i socialt arbete kan problematiseras The gap-mending concept is an analytical tool that helps teachers and researchers in social work to reflect upon what, in their practice, increases, maintains or mends gaps between professionals and service user groups. The article suggests a theoretical background on how gaps in social work practice can be challenged. This includes theories about power and recognition. It then moves on to describ

BACKGROUND: Although people with intellectual disability (ID) and people with dementia have high drug prescription rates, there is a lack of studies investigating drug use among those with concurrent diagnoses of ID and dementia.AIM: To investigate the use of antipsychotics, benzodiazepine derivatives, and drugs recommended for dementia treatment (anticholinesterases [AChEIs] and memantine) among

Atrial fibrillation (AF) is common among the elderly, and has serious consequences such as stroke and increased mortality. Not all of the population attributable risk for AF is explained by known risk factors. This thesis used epidemiological methods and two population based cohorts- the Malmö Preventive project (MPP) and the HOMA sub study of the Malmö Diet and Cancer Study (MDCS)- to analyse the

OBJECTIVE: Investigate the association of chronic depressive symptomatology (chrDS) with cortical atrophy rates and conversion to Alzheimer dementia (AD) over 3 years in mild cognitive impairment (MCI).METHODS: In a multicenter, clinic-based study, MCI elderly participants were selected from the Alzheimer's Disease Neuroimaging Initiative repository, based on availability of both serial structural

In this paper two architectures for tunable duplexersare presented. The tuning is accomplished through variablecapacitance and resistance. The architectures are based on athree element series-parallel resonator, with one pass and onestop frequency. Both architectures rely on filtering as well ascancellation for good Tx to Rx isolation while maintaining lowinsertion loss. The first architecture, the

Three visible lines of M1 transitions from In-like tungsten were recorded using the Shanghai Permanent Magnet Electron Beam Ion Trap. The experimental wavelengths were measured as 493.84 ± 0.15, 226.97 ± 0.13 and 587.63 ± 0.23 nm (vacuum wavelengths). These results are in good agreement with theoretical predictions obtained using the large-scale relativistic many-body perturbation theory, in the f

In this work, we have synthesized injectable bone cement incorporated with gelatin to enhance cellular interaction. Human osteosarcoma Saos-2 cells derived bone morphogenetic proteins (BMP's) and a bisphosphonate (zoledronic acid (0.2 mM)) were also incorporated to cement. In vitro studies conducted using Saos-2 demonstrated enhanced cell proliferation on gelatin (0.2%w/v) cement. The differentiat

BACKGROUND: Knowledge about age-specific normal values for left ventricular mass (LVM), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) by cardiac magnetic resonance imaging (CMR) is of importance to differentiate between health and disease and to assess the severity of disease. The aims of the study were to determine age and gender specific nor

OBJECTIVES: The aim of this study was to compare fully quantitative cardiovascular magnetic resonance (CMR) and positron emission tomography (PET) myocardial perfusion and myocardial perfusion reserve (MPR) measurements in patients with coronary artery disease (CAD).BACKGROUND: Absolute quantification of myocardial perfusion and MPR with PET have proven diagnostic and prognostic roles in patients