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Mycobacterium, the most common disease-causing genus, infects billions of people and is notoriously difficult to treat. Understanding the subcellular localization of mycobacterial proteins can provide essential clues for protein function and drug discovery. In this article, we present a novel approach that focuses on local sequence information to identify localization motifs that are generated by
Amyloid-β (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial temporal lobe. However, there is evidence that, independently of Aβ, age-related tau pathology might be present outside of the medial temporal lobe. We therefore aimed to study age-related Aβ-independent tau deposition outside the medial temporal lobe in two large cohorts and to investigate potential downstr
Stricter regulations on emissions and higher demands on engine performance drive automotive industries to replace conventional gray cast iron with compacted graphite iron (CGI). CGI has a higher wear resistance, strength, elastic modulus, and almost double fatigue strength as to gray cast iron, yet the same positive properties make CGI more difficult to machine. This study focuses on finish millin
There is a high demand to design and develop recyclable biobased polymers using eco-friendly synthetic approaches. In this work, we present the facile synthesis of two dicarboxylate monomers with a central non-cyclic acetal unit (dimethyl 4,4'(methylenebis(oxy))dibenzoate and dimethyl 4,4'-(methylenebis(oxy))bis(3-methoxybenzoate)), using potentially biosourced methyl paraben and methyl vanillate.
Invasive alien species threaten biodiversity with domestic gardens acting as a major pathway for the introduction of alien species. Even though the Nordic region is not currently a hotspot for biological invasions, the number of invasions in the Nordic area has been predicted to increase due to climate change. Given a time lag between introduction and invasion, many non-invasive horticultural alie
The host Maria Bach speaks to Evelina Kallträsk, David Larsson Heidenblad, Anna Nilsson Hammar and Johan Östling about the history of knowledge and how its approaches might be useful for historians of economics.In a new episode of the podcast Ceteris Never Paribus, the host Maria Bach speaks to Evelina Kallträsk, David Larsson Heidenblad, Anna Nilsson Hammar and Johan Östling, all members of the Lund Centre for the History of Knowledge (LUCK). They discuss what is the history of knowledge and how its approaches might be useful for historians of economics.
This paper studies the problem of coordinating a group of nth-order integrator systems. As for the well-studied conventional consensus problem, we consider linear and distributed control with only local and relative measurements. We propose a closed-loop dynamic that we call serial consensus and prove it achieves nth order consensus regardless of model order and underlying network graph. This alle
Biomass residues have been identified as potentially promising resources for production of bio-based products and fuels with low climate impacts. Unlike primary biomass such as crops, using residual biomass may avoid issues such as competition over land for food and feed production. To assess the climate impacts of products made from residual biomass, a life cycle assessment (LCA) may be used, butBiomass residues have been identified as potentially promising resources for production of bio-based products and fuels with low climate impacts. Unlike primary biomass such as crops, using residual biomass may avoid issues such as competition over land for food and feed production. To assess the climate impacts of products made from residual biomass, a life cycle assessment (LCA) may be used, but
What are the views of the Italian secondary school students about the future of education, and what conception of Europe are they developing? This report presents the results of the survey “Futures for education and europeanity”, which in 2021, in the midst of the pandemic, collected the opinions of the Italian Provincial Student Councils, representative bodies spread throughout the country, about
We extend the generalized information criteria for high-dimensional penalizedmodels to sparse statistical jump models, a new class of statistically robust and computationally efficient alternatives to hidden Markov models. In a simulation study, we demonstrate that the new generalized information criteria selects the correct hyperparameters with high probability. Finally, providing an empirical ap
En av den moderna demokratins mest bestående, och i allt högre grad aktuella, frågor är om, och i vilket avseende, folket kan vara närvarande. Samtidigt som folkets närvaro har, och alltjämt fortsätter att vara, demokratins villkor, har det sedan länge ansetts omöjligt för folket att vara närvarande i faktisk bemärkelse. Enligt det konventionella narrativet har denna frånvaro setts som en nödvändiIn modern political thought, one of the most recalcitrant, and increasingly pressing, questions of modern democracy is whether, and in what sense, the people can be present. While the presence of the people has, and continues to be, the sine qua non of the democratic form of government, it has also been for a long time held that the people cannot be present literally or in fact. According to the c
This book addresses an under-researched area within populism studies: the discourse of supporters of populist parties. Taking the 2019 European elections as their case study, the authors analyse how supporters in eleven different countries construct identities and voting motivations on social media. The individual chapters comprise a range of methods to investigate data from different social mediaThis book addresses an under-researched area within populism studies: the discourse of supporters of populist parties. Taking the 2019 European elections as their case study, the authors analyse how supporters in eleven different countries construct identities and voting motivations on social media. The individual chapters comprise a range of methods to investigate data from different social media
Filmen handlar om avhandlingen Kustnära yrkesfiske i förändring: Från mångsysslare till entreprenör som prisades med utmärkelsen Årets ciceron i besöksnäringen 2022 av Stiftelsen för kunskapsfrämjande inom turism och BFUF. Det kustnära yrkesfisket är idag en del av besöksnäringen. Malin Anderssons forskning visar hur det här går till. Det värdskap som yrkesfiskarna bedriver i hamnarna blir som lär
Epithelial cells play an important role in maintaining the intestinal mucosa barrier, a barrier that is impaired in several inflammatory conditions. The mechanisms behind this impairment are not known, but it can be presumed that structural alterations of the epithelial cells are involved. In support of this notion, we here show the inflammatory mediator leukotriene D4 (LTD4) triggered first a rap
