Extension of the substrate range is among one of the metabolic engineering goals for microorganisms used in biotechnological processes because it enables the use of a wide range of raw materials as substrates. One of the most prominent examples is the engineering of baker’s yeast Saccharomyces cerevisiae for the utilization of D-xylose, a five-carbon sugar found in high abundance in lignocellulosi

Recent theoretical explanations for how hydrodynamic-like flow can build up quickly in small collision systems (hydrodynamization) has led to a microscopic picture of flow building up in a gluon-dominated phase before chemical equilibrium between quarks and gluons has been attained. The goal of this contribution to Offshell-2021 is to explore consequence of assuming a long-lived gluon-dominated ph

Increasing exports of Fe and DOC from soils, causing browning of freshwaters, have been reported in recent decades in many regions of the northern hemisphere. Afforestation, and in particular an increase of Norway spruce forest in certain regions, is suggested as a driver behind these trends in water chemistry. In this study, we tested the hypothesis that the gradual accumulation of organic soil l

Maternal stress during gestation has the potential to affect offspring development via changes in maternal physiology, such as increases in circulating levels of glucocorticoid hormones that are typical after exposure to a stressor. While the effects of elevated maternal glucocorticoids on offspring phenotype (i.e., “glucocorticoid-mediated maternal effects”) have been relatively well established

The publication of our article “Introducing the dilemma of societal alignment for inclusive and responsible research and innovation” (Ribeiro et al., 2018) was accompanied by three commentaries (Guston, 2018; Nordmann, 2018; and Kuzma and Roberts, 2018). In the original article, we invoked Collingridge’s dilemma of the social control of technology to introduce a complementary dilemma of “societal

Parental influence over children’s status attainment has historically been argued to be key. However, the cross-sibling influence has been scarcely studied for historical periods and for steam family societies, being the most long-lasting relationship across individuals’ lives once childhood was surpassed. We investigate how intra-generational family relationships determine the social destiny of s

Asymmetric construction of dithiodiketopiperazines on otherwise achiral scaffolds remains a pivotal synthetic challenge encountered in many biologically significant natural products. Herein, we report the first total syntheses of (−)-glionitrin A/B and revise the absolute configurations. Emerging from the study is a novel oxidative sulfenylation of triketopiperazines that enables asymmetric format

In this thesis we study efficient solvers for space-time discontinuous Galerkin spectral element methods (DG-SEM). These discretizations result in fully implicit schemes of variable order in both spatial and temporal directions. The popularity of space-time DG methods has increased in recent years and entropy stable space-time DG-SEM have been constructed for conservation laws, making them interes

The PICT method (pollution-induced community tolerance) can be used to assess whether changes in soil microbial response are due to heavy metal toxicity or not. Microbial community tolerance baseline levels can, however, also change due to variations in soil physicochemical properties. Thirty soil samples (0–20 cm), with geochemical baseline concentrations (GBCs) of heavy metals and from five diff

There is emerging evidence of an association between epigenetic modifications, glycemic control and atherosclerosis risk. In this study, we mapped genome-wide epigenetic changes in patients with type 2 diabetes (T2D) and advanced atherosclerotic disease. We performed chromatin immunoprecipitation sequencing (ChIP-seq) using a histone 3 lysine 9 acetylation (H3K9ac) mark in peripheral blood mononuc

We report on pulse contrast characterization of the output of a gas-filled multi-pass cell employed for 20-fold compression of a high-power Yb:YAG laser. We demonstrate an energy content of 80% in the compressed fs pulse.

Background: Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension are chronic diseases with a severe symptom burden. Common symptoms are dyspnoea at light activity and general fatigue that limits daily activities. Respiratory modulation by device-guided breathing decreased symptoms in patients with heart failure. The aim of this pilot study was to investigate if respira

Checkpoints er fremtrædende og helt uomgængelige i nye syriske romaner skrevet i krigsårene. Checkpoint(s) (ḥājiz – pl. ḥawājiz) er en del af det nye litterære ordforråd efter 10 år med opstand og konflikt. Checkpointene er centrale elementer i de landskaber historierne udspiller sig i, de styrer den narrative struktur og tydeliggør væsentlige temaer i den tilværelse i krig, litteraturen fremstillCheckpoints are prominent and completely unavoidable in new Syrian novels depicting the war years. Checkpoint (s) (ḥājiz / ḥawājiz) are part of the new literary vocabulary after ten years of revolt and conflict. The checkpoints are central elements in the landscapes in which the stories take place, they guide the narrative structure, and accentuate essential themes in the life in war. Confrontatio

The production of blood cells is regulated by the action of external factors, cytokines, that can be released by many cell types. In the first place, a population of multipotent stem cells, mostly in the resting Go phase of the cell cycle, but with self-renewal capacity, gives rise to progenitor cells that are predetermined for differentiation into all kinds of blood cells. Expression of genes for

Contamination is the most common and arguably the most significant problem scientists are facing in experimental surface science research that is practiced in the presence of gases. It is fair to say that contamination problems are often worse with ambient pressures compared to conventional experiments in vacuum. It is one of the main reasons for poor reproducibility in this field and in relevant

Languages of diverse structures and different families tend to share common patterns if they are spoken in geographic proximity. This convergence is often explained by horizontal diffusibility, which is typically ascribed to language contact. In such a scenario, speakers of two or more languages interact and influence each other’s languages, and in this interaction, more grammaticalized features t

The severity of the crisis in the Southern Eurozone countries is frequently attributed to inflated economies and reckless spending. Thus, it isn’t surprising that the main interpretation is that the crisis ought to be solved by decreasing government spending and lowering wages. This paper argues, instead, that one of the core underlying reasons for the severity of the crisis in the Southern Eurozo