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Beräkningsmodelleringar har blivit ett allt mer viktigt verktyg inom biologisk forskning. Genom att utföra datorsimuleringar av modeller blir det möjligt att testa hur teorier om biologiska system förhåller sig till experimentell data. Simuleringar kan även användes som ersättning för potentiellt ogenomförbara experiment. En välkonstruerade modells förmåga att göra förutsägelser kan hjälpa till atComputational modelling is becoming an increasingly important tool in biological research. By performing computer simulations of models, it becomes possible to test theories about a biological system against experimental data. Simulations can also be used as a replacement for experiments otherwise unattainable. Well-constructed models have great predictive power which helps improve experimental pr

ObjectivesCancer related pain (CRP) is among the most frequent collateral effects of cancer, with chronic CRP, lasting at least three months, affecting >40% of cancer survivors.Evidence based treatments, including pain-focused Cognitive Behavioral Therapy(CBT) are available, but it appears that cancer patients/survivors are often poorlyinformed about CRP or the potential benefits of CBT for such p

Objective: Changes observed during adult GH deficiency (GHD) are most often reversed with the administration of recombinant human GH (rhGH). To avoid daily injections, a long-acting GH molecule has been obtained by covalent binding of polyethylene glycol (PEG) with rhGH (PEG-GH), allowing weekly s.c. injections. This study was designed to assess its efficacy and safety, in adult GHD subjects.Desig

After the Indian Rebellion of 1857, the colonial administration in British India introduced stricter control over Indian publishers and the press printed in various indigenous languages. Newspapers in the Punjab were monitored and scrutinized from 1864 to understand “native opinions” and identify seditious tendencies. The surveillance resulted in extensive weekly press reports that were considered

Recension av Annika Ström Melins "Monnets blinda fläck".

Objective: The effects of GH replacement on glucose metabolism in GH-deficient (GHD) adults in clinical practice are not well defined. Therefore, we assessed GH treatment effects on fasting plasma glucose (FPG) and haemoglobin A1c (A1c) concentrations in GHD adults in a clinical setting.Design: Post-hoc analysis of the observational Hypopituitary Control and Complications Study conducted at 157 US

We use environmental transmission electron microscopy to observe in situ the switch from an axial vapor-liquid-solid (VLS) growth mechanism in Au-catalyzed InAs nanowires toward a radial vapor-solid (VS) one, dominated by layers nucleating at the triple-phase line. At elevated temperatures, in addition to high V/III ratios, the affinity for In in the Au catalyst will be greater than that of In in

Aims Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. Methods and results A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European

Declines in European bird populations are reported for decades but the direct effect of major anthropogenic pressures on such declines remains unquantified. Causal relationships between pressures and bird population responses are difficult to identify as pressures interact at different spatial scales and responses vary among species. Here, we uncover direct relationships between population time-se

AbstractSevere perineal trauma (SPT) is a serious complication following vaginal birth. To reduce its incidence rate, various preventive strategies have been implemented in Swedish obstetric units. Collegial midwifery assistance (CMA), involving an additional midwife being present during the active second stage of labour, is a clinical practice that was evaluated in the Oneplus trial, which proved

This article presents measurements of the groomed jet radius and momentum splitting fraction in pp collisions at s = 5.02 TeV with the ALICE detector at the Large Hadron Collider. Inclusive charged-particle jets are reconstructed at midrapidity using the anti-k T algorithm for transverse momentum 60

Species’ range shifts and local extinctions caused by climate change lead to community composition changes. At large spatial scales, ecological barriers, such as biome boundaries, coastlines, and elevation, can influence a community's ability to shift in response to climate change. Yet, ecological barriers are rarely considered in climate change studies, potentially hindering predictions of biodiv

Hadronic resonances are used to probe the hadron gas produced in the late stage of heavy-ion collisions since they decay on the same timescale, of the order of 1–10 fm/c, as the decoupling time of the system. In the hadron gas, (pseudo)elastic scatterings among the products of resonances that decayed before the kinetic freeze-out and regeneration processes counteract each other, the net effect dep

The failure of the EU and its Member States to adequately respond to increased refugee movements since 2015, has caused disagreement on how the principle of solidarity and fair sharing of responsibility should be given effect in the context of a reformed European policy on migration. In September 2020, theEuropean Commission proposed the new Pact on Migration and Asylum which was meant to promote

Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new lo