Inference and simulation in the context of high-dimensional dynamical systems remain computationally challenging problems. Some form of dimensionality reduction is required to make the problem tractable in general. In this paper, we propose a novel approximate Gaussian filtering and smoothing method which propagates low-rank approximations of the covariance matrices. This is accomplished by projec

Primary graft dysfunction (PGD) remains a challenge for lung transplantation (LTx) recipients as a leading cause of poor early outcomes. New methods are needed for more detailed monitoring and understanding of the pathophysiology of PGD. The measurement of particle flow rate (PFR) in exhaled breath is a novel tool to monitor and understand the disease at the proteomic level. In total, 22 recipient

Background: Cystic fibrosis (CF) is most common in populations of Northern European ancestry where the F508del variant predominates. In 2020, Iceland became a member of the European Cystic Fibrosis Society Patient Registry, and we launched an epidemiological study of CF in Iceland. The study aimed to determine the prevalence and the genetic variants present in the country. Furthermore, we aimed to

Although many studies have shown that teachers' vocal health is challenged by noise and the room acoustics, research on classroom sound environment from the perspective of teachers' well-being is scarce. This study aimed to explore the relationship between teachers' wellbeing, voice use and classroom acoustics. In this study, wellbeing refers to self-reported vocal health, self-assessed level of s

Introduction: The current standard treatment for endometrial cancer is a laparoscopic hysterectomy with adnexectomies and bilateral sentinel node resection. A retroperitoneal vNOTES sentinel node resection has several theoretical potential advantages. These include being less invasive, leaving no visible scars, operating without Trendelenburg, and therefore offering the anesthetic advantage of eas

Music therapy is a “vocally demanding profession” [1, p. 46]. Currently, little is known about the prevalence and about the possible risk factors for voice disorders within music therapy. As music therapy workspaces may not always be ideal in terms of acoustics, the aim of the study is to investigate room acoustics and noise as risk factors for possible voice disorders among music therapists in Fi

Is circular economy a wonderful thing with no problems that can solve the climate crisis all by itself? Of course not. Can examining the problems with circular economy help us to better apply its principles and achieve better results?Yes. Dr Alison Stowell and colleagues Professor Hervé Corvellec and Dr Nils Johansson outline criticisms of the principle, and how they could help make the circular e

We program high-dimensional linear optical circuits within a commercial multi-mode fibre, turning it into a generalised multi-outcome measurement device, which allows us to both transport and certify high-dimensional entanglement within the transmission channel itself.

Objective: In this study, we propose a novel framework that utilizes deep learning and attention mechanisms to predict the radiographic progression of patellofemoral osteoarthritis (PFOA) over a period of seven years. Design: This study included subjects (1832 subjects, 3276 knees) from the baseline of the Multicenter Osteoarthritis Study (MOST). Patellofemoral joint regions-of interest were ident

Projektet har fokus på kvalitetskontroll av markstabilisering med elektrisk resistivitetstomografi (ERT). Stabilisering kan göras i form av KC-pelare, jetpelare, ytstabilisering och masstabilisering, genom inblandning av cement, kalk, slagg, flygaska eller kombinationer av dessa. Markstabilisering kan vara mycket attraktivt för såväl miljö som ekonomi, men det finns behov av bättre metoder för kva

In the later Middle Ages and early modern period, many European hospitals developed into commercial retirement homes that allowed investors to pay for lifelong food and lodging. Their clients consisted mainly of elderly citizens who decided to spend their final years enjoying a pension, often living by themselves or occasionally with a spouse. Corrodies can best be understood as life annuities in

In two studies, we examined if correct and incorrect statements in eyewitness testimony differed in semantic content. Testimony statements were obtained from participants who watched staged crime films and were interviewed as eyewitnesses. We analyzed the latent semantic representations of these statements using LSA and BERT. Study 1 showed that the semantic space of correct statements differed fr

BACKGROUND: Low levels of plasma apolipoprotein E (apoE) and presence of the APOE ε4 allele are associated with an increased risk of Alzheimer's disease (AD). Although the increased risk of AD in APOE ε4-carriers is well-established, the protein levels have received limited attention.METHODS: We here report the total plasma apoE and apoE isoform levels at baseline from a longitudinally (24 months)

The Alzheimer's disease (AD) afflicted brain is neuropathologically defined by extracellular amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles composed of hyperphosphorylated tau protein. However, accumulating evidence suggests that the presynaptic protein α-synuclein (αSyn), mainly associated with synucleinopathies like Parkinson's disease (PD), dementia with Lewy bodies (DLB) and

Accumulating evidence demonstrating higher cerebrospinal fluid (CSF) α-synuclein (αSyn) levels and αSyn pathology in the brains of Alzheimer's disease (AD) patients suggests that αSyn is involved in the pathophysiology of AD. To investigate whether αSyn could be related to specific aspects of the pathophysiology present in both sporadic and familial disease, we quantified CSF levels of αSyn and as