Monosubstituted naphthoxylosides have been shown to function as substrates for, and inhibitors of, the enzyme β4GalT7, a key enzyme in the biosynthetic pathway leading to glycosaminoglycans and proteoglycans. In this article, we explore the synthesis of 16 xyloside analogues, modified at two different positions, as well as their function as inhibitors of and/or substrates for the enzyme. Seemingly

Spectator violence is an issue that affects many football matches in Sweden and other countries. Different models have tried to explain why individuals participate in sports fandom and associated behaviors. However, often these models ignore social and individual factors that may impact if and why individuals participate in spectator violence. Outgroup violence can be motivated by pro-social conce

Philosophers have applied the framework of constitutive grounds to make sense of the disagreement between subjectivism and objectivism. The framework understands the two theories as being involved in a disagreement about the extent to which value is determined by attitudes. Although the framework affords us with some useful observations about how this should be interpreted, the question how value

Advanced glycation end products are formed by non-enzymatic reactions between proteins and carbohydrates, causing irreversible lysine and arginine alterations that severely affect protein structure and function. The resulting modifications induce inflammation by binding to scavenger receptors. An increase in advanced glycation end products is observed in a number of diseases e.g. atherosclerosis a

This article analyzes the effect of exporting activity on the innovative performances of firms in France, Germany, Italy, Spain, and UK. It argues that the positive effect of exporting on innovation usually found in the literature varies according to the specific destinations of exports, and it identifies two dimensions along which export destinations might differ: the level of foreign technologic

One common goal of sample analysis is to provide structural, compositional, or functional data in order to improve production parameters. One instrument specialized in such structural and compositional analysis with a high spatial resolution is the transmission electron microscope (TEM). The high-end microscopes have the capability of sub-Ångström resolution and compositional quantification and di

This thesis introduces two new incommensurate alloys. AuIn shows variable amounts of modulation, depending on the measurement temperature. At 400°C the diffraction pattern shows diffuse scattering and a thallium iodide type Cmcm space group. The diffuse scattering condenses into first order satellites on cooling to 300°C and the space group transforms to the incommensurate C-1(α, β, γ)0. I.e. the

The iron carbene complex [FeII(btz)3](PF6)2 (where btz = 3,3′-dimethyl-1,1′-bis(p-Tolyl)-4,4′-bis(1,2,3-Triazol-5-ylidene)) has been synthesized, isolated, and characterized as a low-spin ferrous complex. It exhibits strong metal-To-ligand charge transfer (MLCT) absorption bands throughout the visible spectrum, and excitation of these bands gives rise to a 3MLCT state with a 528 ps excited-state l

Objective To subgroup chronic pain patients using psychometric data and regress the variables most responsible for subgroup discrimination. Design Cross-sectional, registry-based study. Setting and subjects Chronic pain patients assessed at a multidisciplinary pain centre between 2008 and 2015. Methods Data from the Swedish quality registry for pain rehabilitation (SQRP) were retrieved and analyse

Constitutive activation of interferon signaling pathways has been reported in colorectal cancer (CRC), leading to a strong CD8+ T cell response through stimulation of NLRC5 expression. Primed CD8+ T cell expansion, however, may be negatively regulated by PD-L1 expression. Additionally, aberrant PD-L1 expression enables cancer cells to escape the immune attack. Our study aimed to select potential r

Precis efter Big Bang fanns endast tre grundämnen: väte, helium och en liten mängd litium. De första stjärnorna föddes i gasmoln som innehöll dessa ämnen. När den första generationen stjärnor i slutet av sina liv exploderade som supernovor spreds de tyngre grundämnena som tillverkats ut i det interstellära mediet. Nästa generations stjärnor bildades från detta berikade medium, och innehöll därför Atomic data such as oscillator strengths and wavelengths are important for astrophysical applications as they have a crucial role in determining abundances of specific elements in a star, a galaxy, or any object emitting radiation in the space. Stars in the Galaxy mostly keep the composition of the interstellar gas from which they were formed, therefore studying stellar abundances helps us underst

The lifetimes of 17 even-parity levels (3d5s, 3d4d, 3d6s and 4p2) in the region 57 743–77 837 cm−1 of singly ionized scandium (Sc ii) were measured by two-step time-resolved laser induced fluorescence spectroscopy. Oscillator strengths of 57 lines from these highly excited upper levels were derived using a hollow cathode discharge lamp and a Fourier transform spectrometer. In addition, Hartree–Foc

Background: Kallikrein 6 (KLK6) is known to be an age-related protease expressed at high levels in the central nervous system. It was previously shown to be involved in proteolysis of extracellular proteins implicated in neurodegenerative diseases such as Alzheimer's disease (AD), prompting validation of KLK6 as a potential biomarker of disease. However, analyses of both plasma and cerebrospinal f

Whilst health consequences of being locked-in at the workplace have been documented in several research studies, it is largely unknown how work characteristics and their changes over time relate to risks for becoming locked-in at a certain workplace. Accordingly, this paper studied how perceived control, learning opportunities and quantitative demands at work associate with workplace-locked-in (WP

Introduction Attrition from antiretroviral therapy (ART) programmes is a critical challenge among children receiving care in resource-limited settings. Our objective was to determine the rates and predictors of attrition among children on ART in Ethiopia. Methods Between December 2014 and September 2016, we conducted a prospective cohort study in eight health facilities in Ethiopia. Eligibility cr

Background and Aims: Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn's disease [CD] and ulcerative colitis [UC] in a large European population. Methods: In total, 401 326 participants, aged 20-80 years, were recruited in eigh

Cells of complex organisms typically rely on mitochondria for energy provision. The amount of energy required to sustain cellular activity can vary strongly depending on external conditions. Vice versa, constraints on respiratory activity due to metabolic status or stress insult require mitochondrial signaling to coordinate cellular physiology with the function of the organelle. In this update, we

A search is performed for new phenomena in events having a photon with high transverse momentum and a jet collected in 36.7fb-1 of proton–proton collisions at a centre-of-mass energy of s = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider. The invariant mass distribution of the leading photon and jet is examined to look for the resonant production of new particles or the presen