ALK mutations occur in 10% of primary neuroblastomas and represent a major target for precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra-high-risk phenotype resulting in very poor patient prognosis. To open up opportunities for future precision drugging, a deeper understanding of the molecular consequences of constitutive ALK signaling and its relationship to

Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European c

Den senaste reformen av EU:s gemensamma jordbrukspolitik (CAP) sjösattes 2015 med avsikten att göra det europeiska jordbruket mer konkurrenskraftigt och mer hållbart. Syftet med den här rapporten är att analysera vilka effekter reformen kan väntas få på svenskt jordbruk på områdena konkurrenskraft och miljö, för att undersöka om målen med reformen uppfylls eller ej. Analysen bygger på simuleringar

Background: In 2015, six indicators were proposed to evaluate global progress towards access to safe, affordable and timely surgical and anaesthesia care. Although some have been adopted as core global health indicators, none has been evaluated systematically. The aims of this study were to assess the availability, comparability and utility of the indicators, and to present available data and upda

Objectives: To evaluate the effect of preoperative malperfusion on 30-day and late mortality and postoperative complications using data from the Nordic Consortium for Acute Type A Aortic Dissection (ATAAD) registry. Methods: We studied 1159 patients who underwent ATAAD surgery between January 2005 and December 2014 at 8 Nordic centers. Multivariable logistic and Cox regression analyses were perfor

Three-dimensional surveys are required to accurately resolve structures in very complex areas. In many cases the 3-D data set is collated from a series of parallel 2-D survey lines, and frequently the distance between the lines is more than the electrode spacing along the lines. The inversion of such data sets frequently produce models with banded near-surface anomalies that are aligned parallel (

A controlled experiment was carried out by doing geophysical measurements on a purpose-built heap consisting of two different industrial waste fractions, called NF ( non-ferrous metal) and SLF (shredder light fraction), from the recycling plant of Stena Metall in Halmstad, Sweden. The purpose of the experiment was to see if it was possible to distinguish the different types of material using geoph

Across much of the northern hemisphere, lakes are at risk of re-acidification due to incomplete recovery from historical acidification and pressures associated with more intensive forest biomass harvesting. Critical load (CL) calculations aimed at estimating the amount of pollutants an ecosystem can receive without suffering adverse consequences are dependent on these factors. Here, we present a m

Background: Survivors of Hodgkin lymphoma (HL) in childhood have an increased risk of subsequent malignant neoplasms (SMNs). Herein, the authors extended the follow-up of a previously reported Late Effects Study Group cohort and identified patients at highest risk for SMNs to create evidence for risk-based screening recommendations. Methods: The standardized incidence ratio was calculated using ra

Mountain areas often hold special species communities, and they are high on the list of conservation concern. Global warming and changes in human land use, such as grazing pressure and afforestation, have been suggested to be major threats for biodiversity in the mountain areas, affecting species abundance and causing distribution shifts towards mountaintops. Population shifts towards poles and mo

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This study investigates the scratch load effect, from 100 to 2000 mN, on micro-mechanisms involved during scratching. A pearlitic and three ferritic Compacted Graphite Irons (CGI) solution strengthened through addition of 3.66, 4.09, and 4.59 Si wt% were investigated. Good correlation was observed between hardness measurements, tensile testing, and scratch results explaining the influence of matri

Artikel om historiografin kring historiebruk samt en presentation av en typologi över historiebruk.