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A label-free high-throughput protein solubility assay and its application to Aβ40

A major hallmark of Alzheimer's disease is the accumulation of aggregated amyloid peptide (Aβ) in the brain. Here we develop a solubility assay for proteins and measure the solubility of Aβ40. In brief, the method utilizes 96-well filter plates to separate monomeric Aβ from aggregated Aβ, and the small species are quantified with the amine reactive dye o-phthalaldehyde (OPA). This procedure ensure

Winds of change: An engaged ethics approach to energy justice

Theories of energy justice are standardly used to evaluate decision-making and policy-design related to energy infrastructure. All too rarely attention is paid to the need for a method of justifying principles of justice as well as justice-based judgments that are appealed to in this context. This article responds to this need by offering an engaged ethics approach to normative justification usefu

Structure-Property Relationships of Iron N-Heterocyclic Carbene Complexes : Synthesis, Characterization and Application

Resulting from the general availability of first-row transition metals, compared to their second- and third-row counterparts, photosensitizers (PSs) based on metals like iron have gained interest as candidates to enable photochemistry from solar energy, a largely underutilized energy source. Iron complexes equivalent to other metal complexes, currently being used as PS, do lack some of the advanta

Sustainable meetings – communicating to enhance the industry’s resilience

There are many definitions of resilience, but in general it refers to the ability of a system, which may be a community, society, or economic system that are exposed to extreme disturbances, persistent stress, or hazards to resist, absorb, accommodate, adapt to, transform and recover from effects of the situation in a timely and efficient manner (PreventionWeb n.d.;). Sustainability is focused on

Imaginations of the North and the South in Esaias Tegnér's Poetry

The contrast between the North and the South was a recurrent toposin Romantic literature, and in Scandinavia it played a crucial role in theRomantic writers’ search for a national cultural identity. This articledeals with the meaning and function of this imagery in some of EsaiasTegnér’s most famous poems. Being present already in his patrioticand partly Classicist poem ‘Svea’ (1811), Tegnér devel

Interventions aimed to increase average 24-hour systolic blood pressure reduce blood pressure drops in patients with reflex syncope and orthostatic intolerance

BACKGROUND AND AIMS: Systolic blood pressure (SBP) drops recorded by 24-hour ambulatory blood pressure (BP) monitoring (ABPM) identify patients with susceptibility to reflex syncope and orthostatic intolerance. We tested the hypothesis that treatments aimed to increase BP (reassurance, education & life-style measures plus pharmacological strategies) can reduce SBP drops.METHODS: Multicentre, o

On mathematics and physics teaching in upper-secondary school

This article reports on physics teaching in upper-secondary school with a focus on communication and relations made between mathematics, theoretical models in physics, and reality.Video data from four physics classrooms in three different teaching contexts, i.e., lessons, problemsolving, and lab work, have been analysed by combining two theoretical frameworks: the TernaryFramework and Joint Action

Pre-service teachers’ general and specific arguments in real number contexts

A study of pre-service primary school teachers’ content knowledge regarding real numbers related to infinity,i.e., division by zero and denseness of the real number line, was conducted at a Swedish university. Data werecollected twice during the respondents’ teacher education using questionnaires and interviews on bothoccasions. The data were analysed in terms of traces of concept images, focusing