This study investigates a missing value imputation approach for longitudinal growth data in pediatric studies from multiple countries. We analyzed a combined cohort from five natural history studies of type 1 diabetes (T1D) in the US and EU with longitudinal growth measurements for 23,201 subjects. We developed a multiple imputation methodology using LMS parameters of CDC reference data. We measur

The recent years have witnessed science taking gigantic strides and achieving milestones in the areas which were previously rendered to be difficult. Advancements such as the culmination of the Human Genome Project and the successful use of gene therapy have shown how science can be used to alleviate human diseases and benefit society. While basic scientific knowledge is increasing at a remarkable

Atmospheric new-particle formation (NPF) affects climate by contributing to a large fraction of the cloud condensation nuclei (CCN). Highly oxygenated organic molecules (HOMs) drive the early particle growth and therefore substantially influence the survival of newly formed particles to CCN. Nitrogen oxide (NOx) is known to suppress the NPF driven by HOMs, but the underlying mechanism remains larg

The role of biotechnology as a forerunner in the pathway of revolution of human lives has been promising in the recent past. The achievements of biotechnology in the bio-medical front encompass various products like novel vaccines, diagnostic devices, and novel therapeutic strategies. This chapter deals with the principles and processes involved in the attainment of therapeutic tools and treatment

Towards the close of the nineteenth century and into the twentieth century, there was a proliferation of Christian missionaries in Africa. Upon settling in Africa, missionaries initiated and became the main providers of Western-styled education and health care. For this reason, the historical and enduring impact of missionaries in Africa cannot be overlooked. This thesis examines the synchronic an

This chapter focuses on the oxidative stability of n-3 polyunsaturated fatty acids (n-3 PUFAs) delivery systems and n-3 PUFAs fortified foods during digestion, with specific attention given to the long-chain n-3 PUFAs. The topic is of importance since the formation of reactive lipid oxidation products in the gastrointestinal tract (GIT) can lead to unwanted reactions e.g., with proteins, phospholi

A 43-year-old woman was referred to the Eye clinic at Skåne University Hospital complaining of redness and a foreign body sensation in the left eye for 2 to 3 days. Vision was unaffected, and she was otherwise completely well. In particular, there was no itching or swelling elsewhere.

Phase field crystal modeling with wavelet filtering is shown to be an attractive replacement for molecular dynamics simulations when evaluating grain boundary stiffness by the capillary fluctuation method. Obstacles such as iterative equilibration of grain boundary structures and repeated reconstruction of the grain boundary over extended simulations can be avoided.

A memetic version between an evolutionary algorithm (differential evolution) and the local search provided by protein fragment replacements was defined for protein structure prediction. In this problem, it is intended to find the global minimum in a high-dimensional energy landscape to discover the native structure of the protein. This problem presents a multimodal energy landscape which can addit

Adolescent mental health is key for later well-being. Yet, causal evidence on environmental drivers of adolescent mental health is scant. We study how an important classroom feature—the gender composition in compulsory-school—affects mental health. We use Swedish administrative data (N = 576,285) to link variation in gender composition across classrooms within cohorts to mental health. We find tha

Membrane proteins are challenging to study due the necessity to maintain a lipid-like environment to preserve their structure and function. Particularly difficult to study are membrane-bound enzymes that interact with lipophilic substrates. The aim of this doctoral thesis was to investigate the mechanism of action and inhibition of membrane-bound enzymes that interact with lipids and lipophilic su

Background: Factor V-short (FV756-1458) is a natural splice variant functioning in synergy with protein S as tissue factor pathway inhibitor alpha (TFPIα)–cofactor in inhibition of factor Xa (FXa). An exposed acid region (AR2; 1493–1537) in the B domain binds TFPIα. The preAR2 (1458–1492) is crucial for the synergistic TFPIα–cofactor activity between FV-short and protein S and for assembly of a tr

The relation of law and art is conventionally understood through a disciplinary divide that presents art as an instrument of legal practice and scholarship or, alternatively, presents law as potential context for artistic engagement. Moving beyond disciplinary definitions, in this article we explore how art and law, as modes of ordering and action in the world, often overlap in their respective de

Dopamine replacement therapy with L-DOPA is the most efficacious symptomatic treatment for Parkinson's disease, but its utility is limited by a development of motor fluctuations and abnormal involuntary movements (dyskinesia) in the majority of patients. These complications are attributed to the combined effects of dopaminergic degeneration and non-physiological reinstatement of dopamine transmiss

Previous studies have shown that alkali salts influence combustion processes and soot formation, although the effects seem to vary across systems. Moreover, fundamental studies on the effect of potassium and sodium salts on formation of polycyclic aromatic hydrocarbons (PAH), which are precursors in soot formation, are scarce. Here, we report a study in which the effects on PAH formation due to th