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The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. A
An appreciable percentage of patients with serum anti-glomerular basement membrane (anti-GBM) antibodies also have antineutrophil cytoplasmic antibodies (ANCA), against either myeloperoxidase (MPO-ANCA), or proteinase 3 (PR3-ANCA). In sera without ANCA, the anti-GBM antibodies have been shown to react mainly with the noncollagenous domain (NC1) of Type IV collagen, and especially with its alpha 3
2D and 3D models of a superconducting undulator suitable for the ESRF storage ring have been developed. The models are based on the performance of superconducting NbTi wire available from the cabling industry. Iron is used in the poles to enhance the peak field. The 2D model shows that it is possible to obtain a peak field of 1.18 T, corresponding to a K-value of 1.65, for a period length of 15 mm
Popular Abstract in Swedish Förebyggande miljöskyddslösningar har under flera år tillämpats med stor framgång i den tillverkande industrin. Den har dock används i mycket i liten omfattning i service sektorn. I takt med att tjänstesektorns ekonomiska betydelse ökat, har även miljöaspekten av ett ökat tjänsteutbud kommit i fokus. Denna avhandling förklarar hur förebyggande miljöskydd som ett strategPreventative environmental approaches (e.g. Cleaner Production and Pollution Prevention) have been successfully implemented in the manufacturing industry. They are, however, far from being fully adopted by all society actors. It has, for instance, not been fully embraced by the service sector. When this research project started, the initial question was whether it was possible to adopt experiences
High-resolution, non-invasive, 3D-imaging techniques would greatly benefit the investigation of the localization properties of tumor-specific radiopharmaceuticals in laboratory animals. The present study reports how pinhole SPECT can be applied to tumor localization studies in small laboratory animals to provide high resolution SPECT images in vivo. Pinhole SPECT was performed using a rotating sci
Tailfat samples were collected from 56 platypuses, 38 male and 18 fernale in Tasmania. No statistically significant, nor apparent, differences between the sexes were found for tailfat lipid levels and DDT and its metabolites, Lindane and PCB concentrations in tailfat lipid. Apparently-but not statistically-significantly different levels of DDT and its metabolites, Lindane and PCB concentrations we
A piece of a human thoracic duct removed at operation was investigated in organ baths. The duct was cut in 8 ring segments each about 1mm long and isometric tension recorded. The segments were exposed to a potassium rich (124mM) Krebs buffer solution. In only two of the segments were contractions induced (7.2 and 1.0mN, respectively). Noradrenaline and the thromboxane mimetic U-46619 induced tonic
Impacted, morselized bone allografts are used with good clinical results in revision of hip prostheses with loosening and osteolysis. The impacted bone graft appears radiographically to remodel, but histological analyses have shown a heterogeneous picture with a mixture of living and dead bone. Thus, complete remodeling of the graft may be neither a prerequisite nor a cause of the good clinical re
Soil-washing technique was used for the isolation of microfungi from soil of a planted Norway spruce forest in the south of Sweden. About ninety different fungal species were identified. The most frequently isolated genera were Mortierella, Penicillium, and Trickoderma which together constituted 71% of the total number of isolates. A significant (P < 0·01) difference in abundance between the diffe
A gene encoding a lipolytic enzyme amplified from the alkaliphilic bacterium Bacillus halodurans LBB2 was cloned into the pPICZ alpha B vector and integrated into the genome of the protease deficient yeast strain Pichia pastoris SMD1168H. This previously undescribed enzyme was produced in active form, and cloning in frame with the Saccharomyces cerevisiae secretion signal (alpha-factor) enabled ex
Results from a high pressure chamber; recently developed at Lund Institute of Technology, are presented. The compressibility variation with the pressure of five different lubricants is investigated for pressures up to 2.7 GPa. The density variation for each lubricant is presented as a curve fit. The results show that at high pressures when the lubricant has solidified, the density varies linearly
BACKGROUND: The importance of tobacco smoking and Helicobacter pylori infection as risk factors in the development of gastric carcinoma was investigated through multivariate conditional logistic regression analysis in a nested case-control study. METHODS: Blood samples and a questionnaire on smoking habits were collected from a cohort of 32,906 city residents during a health screening programme fr
Rapport från de medicinhistoriska sessionerna
The growth and thermal stability of ultrathin ZrO2 films on the Si-rich Si(0001)-(3 x 3) surface have been explored using photoelectron spectroscopy (PES) and X-ray absorption spectroscopy (XAS). The films were grown in situ by chemical vapor deposition using the zirconium tetra tert-butoxide (ZTB) precursor. The O 1s XAS results show that growth at 400 degrees C yields tetragonal ZrO2. An interfa
