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Skeletal muscle laminin and MDC1A: pathogenesis and treatment strategies.

Laminin-211 is a cell-adhesion molecule that is strongly expressed in the basement membrane of skeletal muscle. By binding to the cell surface receptors dystroglycan and integrin α7β1, laminin-211 is believed to protect the muscle fiber from damage under the constant stress of contractions, and to influence signal transmission events. The importance of laminin-211 in skeletal muscle is evident fro

On the cardinality of systematic authentication codes via error-correcting codes

In both open and private communication the participants face potential threats from a malicious enemy who has access to the communication channel and can insert messages (impersonation attack) or alter already transmitted messages (substitution attack). Authentication codes (A-codes) have been developed to provide protection against these threats. In this paper we introduce a new distance, called

Uridine diphosphate (UDP) stimulates insulin secretion by activation of P2Y(6) receptors.

We examined the transcriptional expression and functional effects of receptors for the extracellular pyrimidines uridine triphosphate (UTP) and uridine diphosphate (UDP), on insulin and glucagon secretion in isolated mouse pancreatic islets and purified beta-cells. Using real-time PCR, the UDP receptor P2Y(6) was found to be highly expressed in both whole islets and beta-cells purified by repeated

Vad menas med personlighet?

The concept of personality is scrutinized as used both in common parlance and in more sophisticated frames of reference. Current multidimensional models are criticized for their reliance on self-descriptive questionnaires and for their lack of a hierarchical dimension, differentiating more or less decisive determinants of behavior. A possible psychoanalytic model is viewed with more benevolence bu

Immunoglobulin constant heavy G subclass chain genes in asthma and allergy.

The IGHG (ImmunoGlobulin constant Heavy G chain) genes are situated close to the IGHE gene on chromosome 14q32, 5'mu, delta, gamma3, gamma1, alpha1, gamma2, gamma4, epsilon, alpha2, 3', in linkage disequilibrium. The polymorphism of gamma3, gamma1 and gamma2 genes, is investigated as alternative allotypes. They are inherited in a Mendelian fashion and are expressed randomly in allelic exclusion. T

Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis.

Ischemic stroke affecting the adult brain causes increased progenitor proliferation in the subventricular zone (SVZ) and generation of neuroblasts, which migrate into the damaged striatum and differentiate to mature neurons. Meteorin (METRN), a newly discovered neurotrophic factor, is highly expressed in neural progenitor cells and immature neurons during development, suggesting that it may be inv

A Mathematical Model of The Atrioventricular Node during Atrial Fibrillation

The atrioventricular (AV) node plays a crucial role during atrial fibrillation (AF). The aim of this study is to present an AV node model which can be fitted to short-term ECG recordings in order to infer certain AV node characteristics. The proposed model is characterized by: i) the arrival rate of atrial impulses; ii) two different refractory periods, corresponding to dual AV nodal paths; iii) t

Effects on cochlear frequency selectivity after hypobaric pressure exposure.

The effects of hypobaric pressure chamber exposure was measured in noise in ten patients with monaural fluctuating low-frequency hearing loss (FLFHL) such as Meniere's disease using psychophysical tuning curves (PTC), transiently evoked otoacoustic emissions (TEOAE), binaural pitch matches and speech recognition scores (SRS) in noise. In the literature, reversible hearing losses have been observed

Adventsuppropet problematiskt

"Vi har problem med Adventsuppropet och den privilegierade ställning som den kristna tron förutsätts ha i det, skriver 18 pastorer och församlingsledare."

Biologisk påväxt på putsade fasader

Vid Byggnadsmaterial LTH studerar vi biologisk påväxt på putsade fasader. Förutom mögel och bakterier som inte gör fotosyntes, så är samtliga andra organismer som växer på fasader fotosyntetiskt aktiva: alger, lavar och mossor. Vårt huvudintresse ligger i att beskriva samspelet mellan klimatet (främst temperatur och fukt) på fasaden, typ av fasad (isolering, putstjocklek, ytskikt, färgtyp etc.) oc

Den svenska konstfilmsinstitutionen

An analysis of the Swedish art cinema as an institutional practice, considered as the art film canon, the film criticism, and the field of cinema studies.

Energy resolved electron – ion coincidence study near the S 2p thresholds of the SF6 molecule

The fragmentation dynamics of the SF6 molecule following the excitations of S 2p electrons into unoccupied molecular orbitals has been studied using the energy-resolved electron–ion coincidence technique. Fragmentation patterns were found to depend on the particular excitation and on the electronic state of the molecular ion. The spectator resonant Auger decay at the 2p → 6a1g resonance induces ch