Background: Pancreatic cancer is a heterogenous disease with a poor prognosis. This study aimed to discover and validate prognostic tissue biomarkers in pancreatic cancer using a mass spectrometry (MS) based proteomics approach. Methods: Global protein sequencing of fresh frozen pancreatic cancer and healthy pancreas tissue samples was conducted by MS to discover potential protein biomarkers. Sele

This dissertation is a collection of three studies in which the main focus is on the role of Swedish L1 speakers’ background languages for the comprehension of written Italian at a lexical level. Italian is one of the foreign languages that Swedish pupils in upper secondary school can choose to study. Previous research on third language acquisition and the role of the background languages in the S

Kognitiva och emotionella svårigheter är vanliga hos personer som överlevt ett hjärtstopp. Rutinerna för uppföljning efter hjärtstopp varierar stort mellan olika regioner och sjukhus i Sverige.För att förbättra vården har Svenska HLR-rådets arbetsgrupp för vård efter hjärtstopp tagit fram svenska riktlinjer för uppföljning efter hjärtstopp.According to previous research, a structured cardiac arrest follow-up may contribute to identifying health problems and the potential need of support among survivors and their relatives. However, a survey on post CA care and follow-up in Sweden, reported a lack of structure and major variations among Swedish hospitals. In 2016, Swedish guidelines were published with the aim to improve care. Accord

Purpose: The purpose of this study was to evaluate how decisions are taken in the early stages of a renovation project, up to the design brief, leading up to the decisions on how to proceed with the renovation in the design phase. Although many technical solutions are visualised in the design phase, it is in the early evaluations of needs and demands, leading up to the design brief, that set the r

Positron emission tomography (PET) is a form of nuclear imaging, which quantitatively assesses the metabolic activity through the uptake of radioactive tracers. 18 F-fluoride is a positron-emitting isotope with high affinity for bone. Despite its potential as a non-invasive measure of bone metabolism, quantitative 18 F-fluoride PET has only been used sparsely in orthopaedic applications. It has

Syftet med denna studie är att undersöka och jämföra hur undervisning i digitala miljöer konstrueras, dels i reflekterande texter skrivna av universitetslärare som deltog i en högskolepedagogisk kurs 2017–2018, dels i styrdokument om e-lärande från svenska lärosäten. Resultatet visar att lärarnas och styrdokumentens diskurser emellanåt står i kontrast till varandra. Medan de senare såväl explicit

The Homogeneous Charge Compression Ignition ({HCCI}) combustion principle lacks direct ignition timing control, instead the auto-ignition depends on the operating condition and fast combustion phasing control is necessary for reliable operation. A six-cylinder heavy-duty HCCI engine was controlled on a cycle-to-cycle basis in real time using a variety of sensors, actuators and control structures f

Bulk properties of cortical bone have been well characterized experimentally, and potent toughening mechanisms, e.g., crack deflections, have been identified at the microscale. However, it is currently difficult to experimentally measure local damage properties and isolate their effect on the tissue fracture resistance. Instead, computer models can be used to analyze the impact of local characteri

Multiplex separation of mixed cell samples is required in a variety of clinical and research applications. Herein, we present an acoustic microchip with multiple outlets and integrated pre-alignment channel to enable high performance and label-free separation of three different cell or particle fractions simultaneously at high sample throughput. By implementing a new cooling system for rigorous t

Background: A fragrance mix consisting of eight separate fragrance ingredients (fragrance mix I [FM I]) is present in most baseline patch test series. Patch testing with the TRUE Test technique is considered to detect less contact allergy to FM I than testing with the Finn Chamber technique. Objective: To investigate the possible significance of batch and patch test method in establishing contact

Anthropogenic land cover change (ALCC) is the most important transformation of the Earth system that occurred in the preindustrial Holocene, with implications for carbon, water and sediment cycles, biodiversity and the provision of ecosystem services and regional and global climate. For example, anthropogenic deforestation in preindustrial Eurasia may have led to feedbacks to the climate system:

Introduction: Community Case Management (CCM) aims to improve health outcomes among children under five with malaria, diarrhea, and pneumonia, but its effectiveness in Malawi is limited by inconsistent standards of delivery characteristic of paper-based interventions. This may lead to negative impacts on child health outcomes and inefficient use of health system resources. This study evaluated the

Background: Endoscopic submucosal dissection (ESD) is an advanced method allowing en bloc resection of large and complex lesions in colon and rectum. Herein, the European experience of colorectal ESD was systematically reviewed in the medical literature to determine the clinical efficacy and safety of colorectal ESD in Europe. Material and methods: A systematic search of PubMed for full-text studi

The radiological consequences of a nuclear power plant (NPP) accident, resulting in the release of radionuclides to the environment, will depend largely on the mitigating actions instigated shortly after the accident. It is therefore important to make predictions of the radiation dose to the affected population, from external as well as internal exposure, soon after an accident, despite the fact

Triose-phosphate isomerase (TIM) catalyses the interconversion of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Two catalytic mechanisms have been proposed based on two reaction-intermediate analogues, 2-phosphoglycolate (2PG) and phosphoglycolohydroxamate (PGH), that have been used as mimics of the cis-enediol(ate) intermediate in several studies of TIM. The protonation states that a

A combination therapy approach is required to improve tumor immune infiltration and patient response to immune checkpoint inhibitors that target negative regulatory receptors. Galectin-3 is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and whose expression correlates with poor survival particularly in patients with non-small cell l