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Kinetic behaviour of WT 1's zinc finger domain in binding to the alpha-actinin-1 mRNA.

The zinc finger transcription factor Wilms tumour protein (WT 1) is known for its essential involvement in the development of the genitourinary system as well as of other organs and tissues. WT 1 is capable of selectively binding either DNA or mRNA targets. A KTS insertion due to alternative splicing between the zinc fingers 3 and 4 and an unconventional zinc finger 1 are the unique features that

Hard real-time guarantees in feedback-based resource reservations

Resource reservation is a technique that allows isolating applications from interfering among each other. In the most classic setting, this method requires the periodic allocation of a given budget of resource over time. However, in reality, the actual budget allocation may deviate from its ideal value. Examples of causes of this deviation are: the presence of a system tick, the usage of shared re

Magnetic Polarons and Large Negative Magnetoresistance in GaAs Nanowires Implanted with Mn Ions.

We report on low-temperature magnetotransport and SQUID measurements on heavily doped Mn-implanted GaAs nanowires. SQUID data recorded at low magnetic fields exhibit clear signs of the onset of a spin-glass phase with a transition temperature of about 16 K. Magnetotransport experiments reveal a corresponding peak in resistance at 16 K and a large negative magnetoresistance, reaching 40% at 1.6 K a

Chemical composition of Late Svecofennian granite in the Bothnian Basin, central Sweden

Late Svecofennian granite is frequent in the Bothnian Basin, especially in zones of rapidly changing metamorphic grade but also in areas, where the metamorphic grade is elevated. The granite is essentially undeformed, but weakly foliated or lineated rocks are common; more rarely are rocks strongly foliated. X-ray fluorescence was used for major-element and ICP-MS for trace-element analyses. The ch

Personalised, predictive and preventive medicine: a decision-theoretic perspective

Background. The last decade has witnessed remarkable developments in medical treatment that is personalised, predictive and preventive. The advances made here have the potential to bring about radical change, not only in diagnostic tests and prescriptions, but also in more fundamental patterns in the provision of health care. Methods. The conceptual framework and principles of modern decision theo

Melatonin heals the gut

Excess alcohol consumption and stress are suggested to be key elements in the development of gastrointestinal disorders (Konturek et al., 2011). Dysfunction of the small intestinal barrier function with increased permeability is a common clinical observation in patients with inflammatory bowel syndrome (IBS) and alcoholic liver disease (Sommansson et al., 2013b). Therapeutic administration of the

Camouflage effectiveness of static nets in SAR images

We present a methodology to determine the camouflage effectiveness of static nets in a SAR image. There is currently no common recognized methodology within the signature management community in this research topic. One step towards establishing a common methodology is to use a standardized target to be camouflaged. We use the STANdard Decoy for CAmouflage Materials (STANDCAM) target developed by

Proton dissociation of sulfonated polysulfones: influence of molecular structure and conformation

The dissociation behavior of proton conducting sulfonated polysulfones has been investigated by combining electrophoretic NMR, pulsed magnetic field gradient NMR and conductivity meas- urements on monomeric and polymeric samples with concentrations of ionic groups in the range where dissociation is not complete (IEC = 4.55 – 7.04 meq g-1). In this regime, counterion con- densation is shown to crit

A Model-Based Injection-Timing Strategy for Combustion-Timing Control

The combustion timing in internal combustion engines affects the fuel consumption, in-cylinder peak pressure, engine noise and emission levels. The combination of an in-cylinder pressure sensor together with a direct injection fuel system lends itself well for cycle-to-cycle control of the combustion timing. This paper presents a method of controlling the combustion timing by the use of a cycle-t

Nurses’ experiences of encountering undocumented migrants in Swedish emergency healthcare

Purpose – The purpose of this paper is to investigate how nurses’ working in emergency health care in Sweden experience their encounter with undocumented migrants. Design/methodology/approach – A total of 16 qualitative interviews were conducted and analyzed using a phenomenographic approach, aiming at describing various ways in which nurses experienced undocumentedness. Findings – The process of

Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study

Limited epidemiological evidence suggests a protective role for plant foods rich in flavonoids and antioxidants in hepatocellular cancer (HCC) etiology. Our aim was to prospectively investigate the association between dietary intake of flavonoids, lignans and nonenzymatic antioxidant capacity (NEAC) and HCC risk. Data from the European Prospective Investigation into Cancer and Nutrition (EPIC) coh

Electrochemical Investigation of Nickel Pattern Electrodes in H-2/H2O and CO/CO2 Atmospheres

In this study, nickel pattern electrodes were electrochemically investigated in a three-electrode setup, operating both with H-2/H2O and CO/CO2 atmospheres. Heating introduced structural differences in the nickel layer among the pattern electrodes, which appear to affect the electrode performance. Both dense and porous nickel pattern electrodes were formed by heating. Holes appeared in the nickel

Visual Expertise In Paediatric Neurology

Objective Visual expertise relies on perceptive as well as cognitive processes. At present, knowledge of these processes when diagnosing clinical cases mainly stems from studies with still pictures. Patient video cases constitute a dynamic and authentic, diagnostic challenge that may simulate seeing and diagnosing a patient in person. This study investigates visual attention and the concomitant co

Relationship between clopidogrel-induced platelet P2Y12 inhibition and stent thrombosis or myocardial infarction after percutaneous coronary intervention-A case-control study

Background Insufficient platelet inhibition is a major determinant of stent thrombosis (STh), although the etiology is multifactorial. On-clopidogrel platelet reactivity was investigated in patients with previous angiographically confirmed STh, myocardial infarction (MI), and controls. Methods Using the Swedish Coronary Angiography and Angioplasty Registry, we identified patients with angiographic

Growth and competitiveness of the New Zealand tree species Podocarpus cunninghamii is reduced by ex-agricultural AMF but enhanced by forest AMF

The composition of arbuscular mycorrhizal fungi (AMF) communities found in agricultural systems has been found to be very different to that of forest. The implications of this, if any, for the restoration of indigenous forest on ex-agricultural land is poorly understood. This study investigated the effect that AMF communities isolated from ex-agricultural and forest soils have on the growth of an

Coastal paleo-environment and sea-level change at Macassa Bay, southern Mozambique, since c 6600 cal BP

Changes in Holocene coastal paleo-environment and sea-level variations have been recorded in estuary sediments from Macassa Bay, southern Mozambique. Methods include analysis of fossil diatoms, sediment stratigraphy, mineral magnetic properties, stable carbon and nitrogen isotope composition and carbon and nitrogen content. The chronology, based on six AMS C-14 dates, suggests a basal age of the s

Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates

We have previously shown that persistent a-synuclein overexpression in ventral midbrain of marmoset leads to a distinctive neurodegenerative process and motor defects. The neurodegeneration was confined to caudate putamen dopaminergic fibers in animals overexpressing wild-type (wt) alpha-synuclein. However, A53T alpha-synuclein overexpression induced neurodegeneration that resulted in nigral dopam

The effect of hydrogen bonding on torsional dynamics: A combined far-infrared jet and matrix isolation study of methanol dimer.

The effect of strong intermolecular hydrogen bonding on torsional degrees of freedom is investigated by far-infrared absorption spectroscopy for different methanol dimer isotopologues isolated in supersonic jet expansions or embedded in inert neon matrices at low temperatures. For the vacuum-isolated and Ne-embedded methanol dimer, the hydrogen bond OH librational mode of the donor subunit is fina