Cyclic nucleotide phosphodiesterases (PDEs) are important regulators of signal transduction processes mediated by cAMP and cGMP. One PDE family member, PDE3B, plays an important role in the regulation of a variety of metabolic processes such as lipolysis and insulin secretion. In this study, the cellular localization and the role of PDE3B in the regulation of triglyceride, cholesterol and glucose

The paper deals with the Cauchy problem for the linear constant-coefficient strongly hyperbolic system $u_t+Au_x=({1}/{delta})B$. The critical case where $B$ has a nontrivial nullspace is investigated. Under suitable assumptions on the matrices $A$ and $B$ the convergence in $L_2$ as $delta o 0$ of the solution $u(·,t,delta)$ of the Cauchy problem is proved. Then the evolution of the limit funct

Air quality standards are set to protect public health. The values of the standards are often based on health effect studies, without any statistical considerations. In order to judge if a standard is met measurements of ambient air quality are taken at monitoring stations, and these measured values are used to decide whether or not the standard has been violated. In this paper we examine the stat

Popular Abstract in Swedish De flesta av Sveriges cirka 15000 större broar är byggda i betong. Ett problem som kan uppkomma i betongbroar är sprickor, vilka kan bidra till att minska broarnas beständighet och säkerhet. I en del broar har fler sprickor uppkommit på sydsidan än på nordsidan vilket antyder att solen har stor påverkan på dessa broar, eftersom det är den enda faktor som skiljer sig väsWhen the temperature changes in the environment the temperature will also change in a structure. Complex interactions of climate factors affect the temperature changes. When the temperature is varied in a material it will expand or contract, and movements will be produced. If the movements are prevented, stresses may be induced which can contribute to cracks in the structure. Severe cracks have be

Inpatient withdrawal treatment (detoxification) is common in opioid dependence, although dropout against medical advice often limits its outcome. This study aimed to assess baseline predictors of dropout from inpatient opioid detoxification with buprenorphine, including age, gender, current substance use, and type of postdetoxification planning. A retrospective hospital chart review was carried ou

This paper presents a hysteretic (sliding mode) control IC for a buck DC/DC converter for use as an envelope tracking power supply to increase the efficiency of an RF power amplifier. The IC integrates a high-bandwidth error amplifier, a comparator with hysteresis, and a high-side driver for an external N-channel power MOSFET. The total control loop delay using the implemented IC is 35ns, this is

Pilgrimage is an important element of Christianity right from the start, being rooted in the Jewish religion. Pilgrimage to sites in the Holy Land develops strongly in the fourth century as the sites are made accessible and are adorned with sanctuaries by the Emperor. The Cross of Christ becomes an important object of devotion to pilgrims, but the story of its discovery is considered by many schol

Popular Abstract in Swedish Hur gick det till när det svenska riket expanderade norrut och införlivade Hälsingland? Denna bok är uppställd som en generalhypotes över denna långt utdragna process, som tar sin utgångspunkt i den samhälleliga kollaps som är skönjbar under 500-talet. De inhemska maktstrukturer som gradvis byggdes upp efteråt kom under medeltidens inledande århundraden att få känna på In which way did the power structures of central Sweden expand into the territories north of the forest Ödmården during the Middle Ages? This text reads like a general hypothesis for this process, which attempts to incorporate all relevant elements in the Medieval landscape of power. The study area chosen is the province of Hälsingland. The chronological take-off is the 6th century AD, when settle

BACKGROUND: Microarray experiments are increasing in size and samples are collected asynchronously over long time. Available data are re-analysed as more samples are hybridized. Systematic use of collected data requires tracking of biomaterials, array information, raw data, and assembly of annotations. To meet the information tracking and data analysis challenges in microarray experiments we reimp