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Reconstitution studies of a protein from domain fragments can furnish important insights into the distinctive role of particular domain interactions and how they affect biophysical properties important for function. Using isothermal titration calorimetry (ITC) and a number of spectroscopic and chromatographic tools, including CD, fluorescence and NMR spectroscopy, size-exclusion chromatography and
This paper is a discussion of theory and methods used in intrasite spatial analysis - the analysis of "living floors". Processes in the formation of the archaeological record such as abandonment, discard, loss, and caching, are discussed. There is also some investigation into factors which may disturb or obscure patterning on an occupation site. Examples to illustrate the discussion are taken from
BACKGROUND: Factors such as age, sex, behaviour problems, fears, earlier traumatic hospital events and reactions to vaccination were assessed together with behaviour observed before premedication in order to evaluate their importance in predicting response to the anaesthetic process. The anaesthetic process was divided into four endpoints; compliance when given premedication, sedation, compliance
PURPOSE: To evaluate the effect of radiation dose reduction on image ++quality in computed musculoskeletal radiography and determine optimal exposure range. MATERIAL AND METHODS: In 11 corpses, 1 hand and 1 hip were examined with film-screen radiography, and a series of computed radiographs was obtained using exactly the same technique except for the exposure, which was 100, 50, 25, 12.5, 6.25, an
To test the genetic relationship between alpine and subalpine forms of Hylocomium splendens, pairwise sampling was undertaken of populations from four areas, representing the southern and northern ranges of the Scandes. From each population I sampled 75 shoots in a hierarchical fashion, and these were screened for variation at 12 allozyme loci. The pairwise genetic identity (I) among subalpine and
The aim of the project has been to elucidate molecular events leading to amyloidosis in Hereditary Cystatin C Amyloid Angiopathy (HCCAA) patients, to enable simple diagnosis of the disease and with the ultimate goal to understand the amyloid formation process in detail, in order to develop inhibitors to the process. At the DNA level, a point mutation segregating with HCCAA was identified in the cy
Objectives and design Knowledge in physiotherapy is based on both scientific evidence and clinical practice. Different perspectives of knowledge generate different implications for theory development. The aim of this qualitative, phenomenographic study was to describe physiotherapists' conceptions of physiotherapy knowledge. Intervention and participants Open, semi-structured interviews were condu
The effects of thermal annealing on the viscoelastic properties and morphology of films prepared from bimodal latex blends containing equal weight fractions of soft and hard latex particles with controlled sizes were investigated. The thermal and viscoelastic properties of as-dried and annealed samples were investigated with differential scanning calorimetry and dynamic mechanical analysis (DMA).
After emigrating from England to Canada in the late 1970s, Robin Wood gained wide recognition as a major “Canadian” film critic, but he was criticized by some for his luke-warm response to the cinema of his adopted country. That response can be traced, in part, to the influence of the English literary critic F.R. Levis, but also to intellectual trends and cultural preferences Wood shared with othe
Preface. The RILEM Committee TC-117 FDC -Freeze-Thaw and De-icing Resistance of Concrete:-started its workwith a first meeting that was hel d in Essen in May 1990. A second meeting was held in Brighton in November the same year. During both meetings, some differences in opinion were disc10sed concerning the effects of different externai and internai factors on the de-icing resistance and concernin
This study aimed to investigate if there is an association between bacterial vaginosis (BV) and smoking. This cohort study included 956 randomly chosen, apparently healthy women at 2 family planning and one youth clinic. Of the 956 women, 131 women fulfilled the criteria for BV and the remaining 825 served as a control group. BV, BV-associated bacteria and gynaecological infections were diagnosed.
Cryocooled crystals of a mercury complex of Escherichia coli dUTPase diffract to atomic resolution. Data to 1.05 Å resolution were collected from a derivative crystal and the structure model was derived from a Fourier map with phases calculated from the coordinates of the Hg atom (one site per subunit of the trimeric enzyme) using the program ARP/wARP. After refinement with anisotropic temperature
The aim of this study was to develop an in-vitro release method suitable for injectable slow-release lipid formulations of local anaesthetics (or other drugs). We also aimed that the results of the in-vitro measurements should have a clear relationship to duration of action in-vivo. Six formulations of bupivacaine base in medium-chain triglyceride-glyceryl dilaurate mixtures were developed. A new
Review of "Sanger fra Adi Granth - sikhenes hellige bok", by Knut A. Jakobsen och Astri Ghosh, published by Verdens Hellige Skrifter, Den norske bokklubbene.
Popular Abstract in Swedish Fordons körmönster, dvs deras hastighets- och accelerationsprofiler, påverkar avgasutsläpp och bränsleförbrukning avsevärt. Detta projekt syftade till att undersöka körmönster i tätort genom att behandla följande delområden: 1) Hur kan körmönster mätas?, 2) Hur kan körmönster beskrivas? – dvs att finna mått för att karakterisera olika egenskaper hos körmönster., 3) Vad Driving patterns, i.e. the speed and acceleration profiles of vehicles affect exhaust emission and fuel consumption considerably. This project was aimed at investigating urban driving patterns by focusing on the following issues: 1) how to measure driving patterns, 2) measures for the description of driving patterns, 3) identification of characteristics of driving patterns that have significant ef
Mouse mammary tumor virus (MMTV) has a proven role in breast carcinogenesis in wild mice and genetically susceptible laboratory inbred mice. The carcinogenic characteristics of this virus are enhanced by estrogen and other steroid hormones. MMTV-like envelope gene sequences, with 95% homology to MMTV have been identified in approximately 40% of breast cancers in US, Australian and Argentinian wome
