AimsImmunohistochemistry plays a pivotal role in cancer differential diagnostics. To identify the primary tumour from a metastasis specimen remains a significant challenge, despite the availability of an increasing number of antibodies. The aim of the present study was to provide evidence-based data on the diagnostic power of antibodies used frequently for clinical differential diagnostics. Method

We hypothesized that tobacco smoke induces alterations to the 3-OH fatty acids present in lipid A in a manner consistent with a microflora of reduced inflammatory potential. Whole saliva samples and full-mouth clinical periodontal recordings were obtained from persons with (22 smokers; 15 nonsmokers) and without (14 smokers; 15 non-smokers) chronic periodontitis. Clear differences in the contribut

Avian ecosystem services such as the suppression of pests are considered to be of high ecological and economic importance in a range of ecosystems, especially in tropical agroforestry. However, how bird predation success is related to the diversity and composition of the bird community, as well as local and landscape factors, is poorly understood. We quantified arthropod predation in relation to t

Mucosal tissues contain large numbers of memory CD4(+) T cells that, through T-cell receptor-dependent interactions with antigen-presenting cells, are believed to have a key role in barrier defense and maintenance of tissue integrity. Here we identify a major subset of memory CD4(+) T cells at barrier surfaces that coexpress interleukin-18 receptor alpha (IL-18Rα) and death receptor-3 (DR3), and d

This paper describes experiments to extract discourse relations holding between two text spans in Swedish. We considered three relation types: cause-explanation-evidence (CEV), contrast, and elaboration and we extracted word pairs eliciting these relations. We determined a list of Swedish cue phrases marking explicitly the relations and we learned the word pairs automatically from a corpus of 60 m

The existence and effect of different rare earth (R2+/3+/IV) ions in SrAl2O4:Eu2+, R3+ and M2MgSi2O7:Eu2+, R3+ (M: Sr, Ba) persistent luminescence materials was studied with XANES (x-ray absorption near edge structure) measurements at HASYLAB/DESY (Hamburg, Germany) and MAX-lab (Lund, Sweden). The experiments were carried out at 298K for selected rare earth (co-) dopants (Eu2+; Ce3+, Nd3+, Sm3+, D

The emission of W and Z gauge bosons off quarks is included in a traditional QCD + QED shower. The unitarity of the shower algorithm links the real radiation of the weak gauge bosons to the negative weak virtual corrections. The shower evolution process leads to a competition between QCD, QED and weak radiation, and allows for W and Z boson production inside jets. Various effects on LHC physics ar

This paper describes the changing everyday life mobility of an older couple living in a suburb in Sweden. The methods used are longitudinal interviews and time-geographical diaries. The results show a pronounced dependence on car use. Representations of suburbia - as places of freedom, independence and mobility enabled by private cars - devolve into a harsh reality, i.e. disabling lock-in effects

Recent studies have highlighted the involvement of rare (15,000 controls (p = 0.009). The discovery of apparent reduced penetrance of ASD in females bearing inherited autosomal SHANK1 deletions provides a possible contributory model for the male gender bias in autism. The data are also informative for clinical-genetics interpretations of both inherited and sporadic forms of ASD involving SHANK1.

We have measured helium and neon concentrations, elemental and isotopic ratios of 91 individual presolar graphite grains from the KFC1 density separate of the Murchison meteorite. Eleven grains contain measurable amounts of either (4)He, (20)Ne, (21)Ne or (22)Ne, or a combination thereof. We report the first detection of (21)Ne from an individual presolar graphite grain and the first detection of

Group G streptococcus (GGS) is a human bacterial pathogen expressing surface proteins FOG and protein G (PG) which interact with several host defense systems, including the complement and contact systems. Selected reaction monitoring mass spectrometry, electron microscopy, and protein binding assays were used to follow the amounts of FOG and PG intracellularly and on the bacterial surface during d

Obesity is a disorder that develops from the interaction between genotype and environment involving social, behavioral, cultural, and physiological factors. Obesity increases the risk for type 2 diabetes mellitus, hypertension, cardiovascular disease, cancer, musculoskeletal disorders, chronic kidney and pulmonary disease. Although obesity is clearly associated with an increased prevalence of hype

Interactions between danger and pathogen-associated molecular patterns (DAMP and PAMP) and pattern recognition receptors such as Toll-like receptors (TLRs) are critical for the regulation of the inflammatory process via activation of NFκB and cytokine secretion. In this report, we investigated the capacity of LPS-free S100A9 (DAMP) protein to activate human and mouse cells compared to lipoprotein-

Inclusive jet and dijet cross sections have been measured in proton-proton collisions at a center-of-mass energy of 7 TeV using the ATLAS detector at the Large Hadron Collider. The cross sections were measured using jets clustered with the anti-kt algorithm with parameters R = 0.4 and R = 0.6. These measurements are based on the 2010 data sample, consisting of a total integrated luminosity of 37 p

Shiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli, which are non-invasive strains that can lead to hemolytic uremic syndrome (HUS), associated with renal failure and death. Although bacteremia does not occur, bacterial virulence factors gain access to the circulation and are thereafter presumed to cause target organ damage. Stx was previously shown to circulate b

Background: The slopes of the eastern Andes harbour some of the highest biodiversity on Earth and a high proportion of endemic species. However, there have been only a few and limited descriptions of carbon budgets in tropical montane forest regions. Aims: We present the first comprehensive data on the production, allocation and cycling of carbon for two high elevation (ca. 3000 m) tropical montan

Effective response to bushfires requires collaboration involving a set of interdependent complex tasks that need to be carried out in a synergistic manner. Improved response to bushfires has been attributed to how effective different emergency management agencies carry out their tasks in a coordinated manner. Previous studies have documented the underlying relationships between collaboration among