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Atrophy and neoplastic transformation of the ileal pouch mucosa in patients with ulcerative colitis and primary sclerosing cholangitis - A case control study
INTRODUCTION: Patients with ulcerative colitis and primary sclerosing cholangitis have an increased risk of developing carcinoma both in the bile ducts and in the colon. PURPOSE: To investigate whether this patient group also has an increased risk of developing atrophy and neoplasia in the deal pouch mucosa after construction of a pelvic pouch with an ileoanal anastomosis or a continent Kock ileos
Patch test sensitization to methylchloroisothiazolinone + methylisothiazolinone and 4,4'-diaminodiphenylmethane.
R-CHOEP-14 X 6 Followed by Systemic CNS Prophylaxis for Diffuse Large B-Cell Lymphoma (DLBCL)/Follicular Lymphoma (FL) Grade 3 with Age Adjusted IPI Score 2-3: Preliminary Results of a Nordic Lymphoma Group (NLG) Phase 2 Study Including 160 Patients Aged 18-64 Years.
Dissection of the genetic complexity of arthritis using animal models.
The exploding progress in genomic technology and knowledge now opens the possibility to actually identify the molecular mechanisms in disease. However, inflammatory diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), are complex and polygenic and remain a challenge. One possible shortcut could be the use of inbred animals as models for RA and MS for the genetic analysis. These
Review of Eleanor Wikborg, "The Lover as Father Figure in Eighteenth-Century Women's Fiction"
Fibronectin fragments cause release and degradation of collagen-binding molecules from equine explant cultures.
OBJECTIVE: Previous experiments have shown that addition of fragmented fibronectin can induce cartilage chondrolysis. In this study we investigated the fate of the collagen- and cell-binding molecules Cartilage oligomeric matrix protein (COMP) and chondroadherin. DESIGN: Equine articular cartilage explants were stimulated with the C-terminal and the N-terminal heparin-binding fragments of fibronec
Additive effects of caspase inhibitor and lazaroid on the survival of transplanted rat and human embryonic dopamine neurons
Major practical constraints on neural grafting in Parkinson's disease are the shortage of human donor tissue and the great loss of dopamine neurons during the grafting procedure. The vast majority of implanted embryonic dopamine neurons are believed to die within a few days of transplantation surgery, at least in part through apoptosis. We have previously found that survival of nigral grafts in ro
Holocene palaeoecology and shoreline displacement on the Biskopsmala Peninsula, southeastern Sweden
High-resolution palaeoecological proxies of pollen, macrofossils and diatoms from an isolation lake provide a long-term record of the Holocene landscape history and shoreline displacement on the Biskopsmala Peninsula in central Blekinge, SE Sweden. During the Preboreal/Boreal transition, the peninsula was sparsely vegetated by woodlands, along with lateglacial dwarf shrub/steppe communities. The l
Fluoxetine use in early pregnancy
Chiral dynamics in the meson sector at two loops
I give a very short introduction to chiral perturbation theory and an overview of the next-to-next-to-leading order three-flavour calculations done. I discuss those relevant for an improvement in the accuracy of the measurement of Vus in more detail. One major conclusion is that all needed p6 low energy constants can be obtained from experiment via the scalar form-factor in K
Immigration history and gene dispersal: allozyme variation in Nordic populations of the red campion, Silene dioica (Caryophyllaceae)
Most of the Nordic region was ice-covered during the last (Weichselian) glaciation. During the postglacial period, plant and animal species recolonized the region from several directions and the geographic structuring of genetic variation within Nordic species may still contain a historic component that reflects patterns of postglacial immigration. The present investigation of 69 populations of Si
Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival
Interleukin-6 (IL6) is a growth and survival factor in human prostate cancer (PCa) cells with aggressive phenotypes and has been implicated in the progression of hormone refractory PCas. In the present study, we characterized the IL6-triggered PI3K/Akt and MAPK/Erk signaling. We identified the A-type cyclin, cyclin A1 as an important downstream target of PI3K/Akt. Treatment of cells with PI3K inhi
The importance of including the pH dependence of sulfate adsorption in a dynamic soil chemistry model
Sulfate adsorption is an important process when modeling the dynamics of recovery from acidification. In the dynamic soil chemistry model SAFE sulfate adsorption is modeled by a pH and sulfate concentration dependent isotherm. This isotherm has been parameterized by fitting it to data from batch experiments on soil samples using multiple linear regression. The soil samples were from the B-horizon
Screening history of women in Malmö with invasive cervical cancer.
Objectives Cervical cancer is one of the most common forms of cancer among women. Cytological screening and follow-up are potentially effective procedures for preventing the development of – and mortality from – cervical cancer. The purpose of this study was to investigate the screening history of women diagnosed with cervical cancer with the aim of improving the screening programme. Study design
A replicated empirical study of a selection method for software reliability growth models
Replications are commonly considered to be important contributions to investigate the generality of empirical studies. By replicating an original study it may be shown that the results are either valid or invalid in another context, outside the specific environment in which the original study was launched. The results of the replicated study show how much confidence we could possibly have in the o
Ice-flow patterns and dispersal of erratics at the southwestern margin of the last Scandinavian Ice Sheet: signature of palaeo-ice streams
An extensive set of proxy-data was acquired from eastern and central Denmark in order to study the dynamic behaviour of the southwestern margin of the last Scandinavian Ice Sheet. We examine the last three glacier advances of the Late Weichselian: the Main advance from central Sweden, representing the maximum ice extent at this time (c. 21-20 ka BP), and the two succeeding Baltic advances (c. 18-1
Investigation of environmental and host-related risk factors for tuberculosis in Africa. II. Investigation of host genetic factors
In an accompanying paper (Am. J. Epidemiol. 2002;155:1066-73), the authors describe the design of a large multicenter study being carried out in three West African countries for investigation of the roles of environmental and host-related factors in the development of tuberculosis. In this paper, the authors review some evidence that host genetic factors play a role in susceptibility to tuberculos
Statistical Estimation and Interpretation of Trends in Water Quality Time Series
Three approaches to trend analysis of water quality time series are discussed: (1) seasonal model, with a test for trend based on ranks of observations, with observations assumed to be m dependent; (2) transfer function noise model, in which covariate series may be included by means of transfer functions, with the remaining noise modeled as a seasonal autoregressive moving average process; and (3)
Is tRNA binding or tRNA mimicry mandatory for translation factors?
tRNA is the adaptor in the translation process. The ribosome has three sites for tRNA, the: A-, P-, and E-sites. The tRNAs bridge between the ribosomal subunits with the decoding site and the mRNA on the small or 30S subunit and the peptidyl transfer site on the large or 50S subunit. The possibility that, translation release factors could mimic tRNA has been discussed for a long time, since their