Purpose: To investigate the impact of reduced injected doses on the quantitative and qualitative assessment of the amyloid PET tracers [18F]flutemetamol and [18F]florbetaben. Methods: Cognitively impaired and unimpaired individuals (N = 250, 36% Aβ-positive) were included and injected with [18F]flutemetamol (N = 175) or [18F]florbetaben (N = 75). PET scans were acquired in list-mode (90–110 min po

In this paper, we investigate a class of braided convolutional codes (BCCs), where the component codes are convolutional self-orthogonal codes (CSOCs), called braided convolutional self-orthogonal codes. Compared to conventional BCCs, the advantages of braided CSOCs include the availability of several low-complexity decoding methods and the relative ease of extending these methods to high rates Mo

Structural deterioration and increasing load demand are two main factors that compromise the serviceability and functioning of civil constructions. The vastity of the bridge portfolio and the few resources available require maintenance optimization to provide the required user safety. In this context, vibration-based monitoring may provide information about the structural performance and support d

Objective: We aimed to test whether region-specific factors, including spatial expression patterns of the tau-encoding gene MAPT and regional levels of amyloid positron emission tomography (PET), enhance connectivity-based modeling of the spatial variability in tau-PET deposition in the Alzheimer disease (AD) spectrum. Methods: We included 685 participants (395 amyloid-positive participants within

Purpose: The primary objective of this research is to determine critical success factors (CSFs) that enable textile enterprises to effectively implement Kaizen, a Japanese concept of continuous development, particularly during disruptive situations. The study aims to provide insights into how Kaizen is specifically employed within the textile sector and to offer guidance for addressing future cris

Background: Growing evidence suggests intergenerational effects of paternal pre-conceptional smoking through the germ line, but its specific impact on offspring semen quality remains uncertain because of challenges in isolating paternal exposure from maternal passive smoking or underreporting. Methods: We reran previous analyses estimating differences in semen parameters and testicular size accord

Som en del av HORIZON EUROPE-projektet AfroSAFE: Säkert system för radikal förbättring av trafiksäkerheten i afrikanska låg- och medelinkomstländer, en översyn av nationella bestämmelser, riktlinjer och procedurer för väginfrastruktursäkerhetshantering (RISM), såväl som vägar. designriktlinjer utfördes i Ghana, Tanzania och Zambia. Information samlades in från relevanta myndigheter och granskningeAs part of the HORIZON EUROPE project AfroSAFE, a review of national regulations, guidelines, and procedures for Road Infrastructure Safety Management (RISM), as well as road design guidelines was carried out in Ghana, Tanzania, and Zambia. Information was collected from relevant authorities and the review had special attention to the safety of vulnerable road users (pedestrians, cyclists, and mot

We compare Holocene tree cover changes in Europe derived from a transient Earth system model simulation (Max Planck Institute Earth System Model - MPI-ESM1.2, including the land surface and dynamic vegetation model JSBACH) with high-spatial-resolution time slice simulations performed in the dynamic vegetation model LPJ-GUESS (Lund-Potsdam-Jena General Ecosystem Simulator) and pollen-based quantita

Purpose: Linked health-care registries and high coverage in Nordic countries lend themselves well to epidemiologic research. Given its relatively high incidence in Western Europe, complexity in diagnosis, and challenges in registration, multiple myeloma (MM) wasselected to compare registries in Denmark, Finland, and Sweden.Patients and Methods: Data were obtained from four archetypal registries in

Pollinators are important drivers of floral trait evolution, yet plant populations are not always perfectly adapted to their pollinators. Such apparent maladaptation may result from conflicting selection through male and female sexual functions in hermaphrodites. We studied sex-specific mating patterns and phenotypic selection on floral traits in Aconitum gymnandrum. After genotyping 1786 offsprin

Innovation and its management in retail organisations is an emerging field, yet the measurement of innovation in this context remains challenging and under-researched. The study investigates innovation in large Swedish retail companies, focusing on monitoring and measurement of innovation performance. Through a qualitative, multiple case study, our findings reveal that retailers are aiming to beco

The parameters of PMSM with inter-turn fault are identified using a time-stepping finite element method (FEM). Analytical expressions (AE) uses the estimated parameters for fault analysis similar to FEM analysis. The fault waveforms, terminal voltages, obtained from the AE models are used for inter turn fault (ITF) detection, using Stator Flux Linkage DC offset (SFDO). A comparison is made between

Sphingosine-1-phosphate (S1P) is a phosphosphingolipid with pleiotropic biological functions. S1P acts as an intracellular second messenger, as well as extracellular ligand to five G-protein coupled receptors (S1PR1-5). In the brain, S1P regulates neuronal proliferation, apoptosis, synaptic activity and neuroglia activation. Moreover, S1P metabolism alterations have been reported in neurodegenerat

Objective: Cardiovascular disease can be prevented through lifestyle changes, but such changes are often hard to attain. Text message interventions with lifestyle advice have shown small but promising effects. Our objective was to explore participant experience of a text message lifestyle intervention for patients with hypertension, and implications for future lifestyle interventions. Design and s

The effects of NPM have been criticized for decades and we are now seeing how alternative, post-NPM, governance innovations emerge. What joins these innovations is the critique against NPM and the ambition to provide new ways of governing public organizations. From a critical stance, we engage in a discussion of governance innovations from the perspective of social imaginaries and analyse post-NPM