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Understanding and improving microbial cell factories through Large Scale Data-approaches

Since the advent of high-throughput genome sequencing methods in the mid-2000s, molecular biology has rapidly transitioned towards data-intensive science. Recent technological developments have increased the accessibility of omics experiments by decreasing the cost, while the concurrent design of new algorithms have improved the computational work-flow needed to analyse the large datasets generated

The constitutive power of maps in the Arctic

Kartor används, cirkuleras och erkänns och har därmed konsekvenser för hur människor uppfattar världen. Kartor förmedlar politiskt meningsskapande och sätter ramar för vilka politiska alternativ som får komma till tals eller som tystas ned. Till skillnad från dominerande tillvägagångssätt för att studera makten hos kartor, som betraktar kartors politiska inflytande utifrån kartproducentens avsikteAs maps are widely used, circulated, and recognised, they have consequences for how people view and understand the world. They mediate political meaning-making and frame the conditions for political alternatives to emerge or to be silenced. In contrast to dominant approaches to the study of the power of maps that consider their political influence on the basis of the intentions of the map-maker, t

Fairness conceptions and self-determined mitigation ambition under the Paris Agreement : Is there a relationship?

This paper investigates the empirical relationship between countries’ expressed concerns with fairness and the ambition levels in their pledged contributions (NDCs) to the Paris Agreement, asking the following questions: 1) Are the NDCs of countries who express the most concern with fairness more or less ambitious than those of other countries? 2) Does the relationship between fairness and ambitio

Dimethylguanidino Valerate : A Lifestyle-Related Metabolite Associated With Future Coronary Artery Disease and Cardiovascular Mortality

Background Identification of lifestyle modifiable metabolic pathways related to cardiometabolic disease risk is essential for improvement of primary prevention in susceptible individuals. It was recently shown that plasma dimethylguanidino valerate (DMGV) levels are associated with incident type 2 diabetes mellitus. Our aims were to investigate whether plasma DMGV is related to risk of future coro

Soft resummation and hard evolution : Renormalization group methods in effective theories and multi scalar models

This thesis is composed out of five papers that deal with various problems intheoretical particle physics. While paper I is a precision calculation in aneffective theory of the Standard Model, paper II to V all deal with beyond theStandard Model physics. Paper IV is a manual for the tools developed during ourwork on paper II to V.Paper I. We calculate the 2-loop soft function for the transverse moThis thesis is composed out of five papers that deal with various problems intheoretical particle physics. While paper I is a precision calculation in aneffective theory of the Standard Model, paper II to V all deal with beyond theStandard Model physics. Paper IV is a manual for the tools developed during ourwork on paper II to V.Paper I. We calculate the 2-loop soft function for the transverse mo

Localization and Regulation of Polymeric Ig Receptor in Healthy and Diseased Human Kidney

The polymeric Ig receptor (PIgR) constitutes an important part of the immune system by mediating transcytosis of dimeric IgA into mucosal fluids. Although well studied in organs such as the intestine, the regulation and localization of PIgR in human kidney are incompletely characterized. Herein, using immunohistochemistry, we show that in healthy human kidneys, PIgR is expressed by the progenitor-

The wealth of the Swedish peasant farmer class (1750-1900) : Composition and distribution

Using about 1,730 probate inventories, this article studies the wealth of peasant farmers in Sweden for the years 1750, 1800, 1850 and 1900. Average wealth grew rapidly, tripling over the nineteenth century, but it did not grow equally: the Gini coefficient for the farmers' wealth grew from 0.46 in 1750 to 0.73 in 1900. Farmers who lived close to the major grain markets in Stockholm and the mining

Intra- and Inter-Rater Agreement Describing Myometrial Lesions Using Morphologic Uterus Sonographic Assessment : A Pilot Study

OBJECTIVES: To evaluate the intra- and inter-rater agreement for myometrial lesions using Morphologic Uterus Sonographic Assessment terminology. METHODS: Thirteen raters with high (n = 6) or medium experience (n = 7) assessed 30 3-dimensional ultrasound clips with (n = 20) and without (n = 10) benign myometrial lesions. Myometrial lesions were reported as poorly or well defined and then systematic

The Political Dynamics of Portfolio Design in European Democracies

The design of government portfolios - that is, the distribution of competencies among government ministries and office holders - has been largely ignored in the study of executive and coalition politics. This article argues that portfolio design is a substantively and theoretically relevant phenomenon that has major implications for the study of institutional design and coalition politics. The aut

Humidity-dependent colour change in the green forester moth, Adscita statices

The colours of insects serve important visual functions in aiding mate recognition, camouflage and warning. The display of insects is usually static, as cuticle coloration does not (or hardly) change during the lifespan of a mature imago form. Here, we describe a case of humidity-dependent, brilliant coloration in the green forester moth, Adscita statices. We show, by employing spectroscopic and u

Prevalence and characteristics of asthma-chronic obstructive pulmonary disease overlap in routine primary care practices

Rationale: Adults may exhibit characteristics of both asthma and chronic obstructive pulmonary disease (COPD), a situation recently described as asthma-COPD overlap (ACO). There is a paucity of information about ACO in primary care. Objectives: To estimate the prevalence and describe characteristics of individuals withACOin primary care practices among patients currently diagnosed with asthma, COP

Conceptualising and situating overtourism in urban contexts

One of the most important trends in contemporary tourism is the increase in urban tourism, both in absolute and in relative terms. In some destinations, e.g. Barcelona, the pressure from tourism on local resources such as housing and urban space has reached a point where we begin to speak about overtourism. The development of overtourism is related to decreasing relative costs of travel, e.g. low-

Situating overtourism in urban contexts

One of the most important trends in contemporary tourism is the increase in urban tourism, both in absolute and in relative terms. In some destinations, e.g. Barcelona, the pressure from tourism on local resources such as housing and urban space has reached a point where we begin to speak about overtourism. The development of overtourism is related to decreasing relative costs of travel, e.g. low-