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Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord
Background/Objectives: Motor impairment induced by traumatic brain injury (TBI) may be mediated through changes in spinal molecular systems regulating neuronal plasticity. We assessed whether a focal controlled cortical impact (CCI) TBI in the rat alters expression of the Tgfb1, c-Fos, Bdnf, and Gap43 neuroplasticity genes in lumbar spinal cord. Approach/Methods: Adult male Sprague-Dawley rats (n
Model-based monitoring of industrial reversed phase chromatography to predict insulin variants
Downstream processing in the manufacturing biopharmaceutical industry is a multistep process separating the desired product from process- and product-related impurities. However, removing product-related impurities, such as product variants, without compromising the product yield or prolonging the process time due to extensive quality control analytics, remains a major challenge. Here, we show how
Warning for excessive positivity : Authentic leadership and other traps in leadership studies
We study authentic leadership as a prominent but problematic example of positive leadership that we use as a more general “warning” against the current fashion of excessive positivity in leadership studies. Without trying to cover “everything”, we critically examine the principal tenets of mainstream authentic leadership theory and reveal a number of fundamental flaws: shaky philosophical and theo
The structure of emergent prefabricated housing industries : a comparative case study of Australia and Sweden
Prefabricated housing is a disruptive innovation struggling to take hold in a traditional complex product system (CoPS). It is quicker to produce and has improved environmental performance compared to traditional housing. CoPS have more dense and complex network connections than commodity industries, making disruptive innovation more difficult. Effective relational capabilities can achieve the coo
Validation of a brief Multicultural Cognitive Examination (MCE) for evaluation of dementia
Background: The aims of this study were to present the psychometric properties of a newly designed cognitive screening instrument, the Multicultural Cognitive Examination (MCE), and to compare it with the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural population. Methods: The study was a Western European cross-sectional multicenter study. The MCE consists of four components
Stopover departure decisions in autumn are not associated with constitutive immune function in Northern Wheatears Oenanthe oenanthe
Stopover periods in between migratory flights determine the speed of migration and as such may affect birds’ fitness. The decision to leave a stopover site is affected by, for example, energy stores and weather conditions. We investigated whether immunological state influences autumn stopover departure decisions in Northern Wheatear (Oenanthe oenanthe), a nocturnal long-distance migrant. We measur
Association between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients with Alzheimer Disease
Importance: Plasma neurofilament light (NfL) has been suggested as a noninvasive biomarker to monitor neurodegeneration in Alzheimer disease (AD), but studies are lacking. Objective: To examine whether longitudinal plasma NfL levels are associated with other hallmarks of AD. Design, Setting, and Participants: This North American cohort study used data from 1583 individuals in the multicenter Alzhe
Can we reduce the workload of mammographic screening by automatic identification of normal exams with artificial intelligence? A feasibility study
Purpose: To study the feasibility of automatically identifying normal digital mammography (DM) exams with artificial intelligence (AI) to reduce the breast cancer screening reading workload. Methods and materials: A total of 2652 DM exams (653 cancer) and interpretations by 101 radiologists were gathered from nine previously performed multi-reader multi-case receiver operating characteristic (MRMC
Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-b aggregates
The aggregates of the Ab peptide associated with Alzheimer's disease are able to both grow in size aswell as generate, through secondary nucleation, new small oligomeric species, that are major cytotoxins associated with neuronal death. Despite the importance of these amyloid fibril-dependent processes, their structural and molecular underpinnings have remained challenging to elucidate. Here, we c
A novel missense variant in IDH3A causes autosomal recessive retinitis pigmentosa
Background: Inherited retinal degenerations (IRDs) encompass a wide spectrum of genetic ocular diseases characterized by considerable genetic and clinical heterogeneity. Methods: Complete ophthalmic examination and next-generation sequencing. Results: We describe a patient with no family history of vision loss, who at the age of 28 years developed visual impairment consistent with a severe form of
Di- and tetrairon(III) μ-oxido complexes of an N3S-donor ligand : Catalyst precursors for alkene oxidations
The new di- and tetranuclear Fe(III) μ-oxido complexes [Fe 4 (μ-O) 4 (PTEBIA) 4 ](CF 3 SO 3 ) 4 (CH 3 CN) 2 ] (1a), [Fe 2 (μ-O)Cl 2 (PTEBIA) 2 ](CF 3 SO 3 ) 2 (1b), and [Fe 2 (μ-O)(HCOO) 2 (PTEBIA) 2 ](ClO 4 ) 2 (MeOH) (2) were prepared from the sulfur-containing ligand (2-((2,4-dimethylphenyl)thio)-N,N-bis ((1-methyl-benzimidazol-2-yl)methyl)ethanamine (PTEBIA). The tetrairon
Species of Horismenus Walker (Hymenoptera : Eulophidae) associated with bruchid beetles (Coleoptera: Chrysomelidae: Bruchinae), including five new species
Species of Horismenus Walker associated with bruchid beetles are investigated and five new species are described. Some of the new species are very similar to already described species and have previously been misidentified. The new species include H. depressoides sp. nov. similar to H. depressus Gahan, H. stator sp. nov. similar to H. missouriensis (Ashmead), and H. dennoi & H. multistriatus s
Evaluation of the Swedish National Stroke Campaign : A population-based time-series study
Background: Time delay from stroke onset to hospital arrival is an important obstacle to recanalization therapy. To increase knowledge about stroke symptoms and potentially reduce delayed hospital arrival, a 27-month national public information campaign was conducted in Sweden. Aim: To assess the effects of a national stroke campaign in Sweden. Methods: This nationwide study included 97,840 patien
A vocabulary describing health-terms of movement quality–a phenomenological study of movement communication
Purpose: The aim of the study was to develop a vocabulary targeting communication of health-terms of movement quality, establishing professional knowledge of a movement terminology usefull within rehabilitation. Methods: A phenomenological study design was chosen, inviting movement experts working in rehabilitation to describe movement observations when a change into more functional, health relate
Utvärdering av innovationstjänsten OnDemand (Behovsanpassad tömning) och uppkopplade avfallskärl - Intervjuanalys av testpersoner och personal i samband med bestäm-själv-tömning.
Artificial wetlands and irrigated vegetation for extraction of nutrients from residual solid wastes treated in landfill bioreactor cells – an important part of a circular economy.
Implementing an EU opt-in mechanism for GM crop cultivation
Assessing potential vulnerability and response of fish to simulated avian predation after exposure to psychotropic pharmaceuticals
Psychotropic pharmaceuticals present in the environment may impact organisms both directly and via interaction strengths with other organisms, including predators; therefore, this study examined the potential effects of pharmaceuticals on behavioral responses of fish to avian predators. Wild-caught juvenile perch (Perca fluviatilis) were assayed using a striking bird model after a seven-day exposu
Mechanical Properties of Boron Phosphides
Microstructure and mechanical properties of bulk polycristalline boron phosphides (cubic BP and rhombohedral B12P2) have been studied by scanning electron microscopy and micro- and nanoinden-tation. The obtained data on hardness, elastic properties and fracture toughness clearly indicate that both phosphides belong to a family of hard phases and can be considered as prospective binders for diamond