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The effect of human pancreatic polypeptide (HPP) on rat pancreatic acini has been studied. It was found that HPP stimulated amylase and lipase release from the acini. The secretory response of acini to HPP was dose-dependent in a sigmoidal fashion. Between 10(-9) M and 10(-8) M concentration of HPP there was a slow increase of enzyme release to about 40-60% over basal release. At concentrations of
Colipase is excreted as a procolipase, colipase101. It is activated by low concentrations of trypsin, hydrolyzing the N-terminal pentapeptide. With higher concentrations of trypsin or in the presence of Ca2+ a smaller form of colipase containing 85 amino acids, appears. It has glycine as the N-terminal and arginine as the C-terminal amino acid residue and has lost 11 amino acids in the C-terminal
Colipase exists in pancreatic juice in a pro-form which is activated by limited trypsin hydrolysis. During this activation, the N-terminal pentapeptide 1Val-Pro-Asp-Pro-5Arg is cleaved. The new N-terminal sequence formed, 6Gly-Ile-Ile-Ile-10Asn, contains three isoleucine residues. The importance of these for stimulating lipase activity has been investigated by successive Edman degradation of epsil
This study examines a recent reform in the Swedish teaching profession—the so-called first teacher reform, aimed at increasing teacher professionalism and the status of teachers. The reform created a situation by which a new role had to be created and inhabited by first teachers, appointed on what were considered arbitrary criteria. There were few existing norms, rules, and routines to draw upon f
Vilken slags profession är lärarkåren? Är lärarkåren ens en profession? Vad innebär autonomi och hur påverkas en yrkesgrupp av att det uppstår hierarkier inom den? Den här boken, om förstelärarreformens införande i svensk skola, för en nyanserad diskussion av dessa frågor som ytterst handlar om förutsättningarna för lärares yrkesutövning.Författarna visar att förestelärarreformen har stärkt lärarn
This article seeks to develop the recent attention to memory by outlining a hermeneutical approach that links memory closely to philosophical reflections on referentiality, narrativity and temporality. From insights of modern and ancient theories of memory, the the present approach insists that memory is referential in that its images are held to derive from outside memory, that it is narrative in
OBJECTIVES: To determine the genetic background underlying the Pk phenotype in two Thai sisters suffering from multiple spontaneous abortions.BACKGROUND: The P antigen is carried by globoside, an abundant glycosphingolipid in the red blood cell (RBC) membrane. Inactivating mutations in the 3-β-N-acetylgalactosaminyltransferase gene (B3GALNT1) give rise to the rare Pk phenotype, which lack the P an
