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In our previous genome-wide scan of Finnish nuclear families, obesity was linked to chromosome Xq24. Here we analyzed this 15-Mb region by genotyping 9 microsatellite markers and 36 single nucleotide polyp morphisms (SNPs) for 11 positional and functional candidate genes in an extended sample of 218 obese Finnish sibling pairs (sibpairs) (BMI > 30 kg/m(2)). Evidence of linkage emerged mainly from

The life histories of holo-anhydrobiotic animals differ from those of all other organisms by a regular or irregular entrance into an ametabolic state induced by desiccation. Such ametabolic periods will arrest growth and reproduction completely and thus affect primary life history parameters dramatically. The selective forces and the genetic and physiological trade-offs acting on anhydrobiotic ani

In this paper some integral formulas for the fatigue damage in variable amplitude loading are presented. The formulas, which in their original form appeared in Rychlik (1993), may be used for both the theoretical analysis of the fatigue damage, resulting from different cycle counting algorithms, as well as for the computation of different statistical properties of the fatigue damage.

Genetic variants in the gene encoding for transcription factor-7-like 2 (TCF7L2) have been associated with type 2 diabetes (T2D) and impaired beta cell function, but the mechanisms have remained unknown. We therefore studied prospectively the ability of common variants in TCF7L2 to predict future T2D and explored the mechanisms by which they would do this. Scandinavian subjects followed for up to

Litteraturvetaren Magnus Nilsson gör olika läsningar av Joseph Conrads Mörkrets hjärta.

We demonstrate how to generalize two of the most well-known random graph models, the classic random graph, and random graphs with a given degree distribution, by the introduction of hidden variables in the form of extra degrees of freedom, color, applied to vertices or stubs (half-edges). The color is assumed unobservable, but is allowed to affect edge probabilities. This serves as a convenient me

To fully support refactorings in a team development environment we have implemented a refactoring-aware repository provider as an extension plug-in to the Java Development Tools in Eclipse. The versioning system treats refactorings as first-class changes described as semantic ac- tions rather than the set of resulting changes scattered over the source tree. We also introduce refactoring-aware merg

n this study we use the N-substituted benzamides declopramide (3-CPA) and N-acetyl declopramide (Na-3-CPA) to investigate the involvement of the transcription factor NF-κB in the induction of apoptosis and surface immunoglobulin κ (Igκ) expression in the mouse pre-B cell line 70Z/3. We first showed that 3-CPA-induced apoptosis at doses around 500 μM and that the 3-CPA-induced apoptosis could be su

Seven novel diterpenoids, named heptemerones A-G, were isolated from the broth of submerged cultures of Coprinus heptemerus, a basidiomycete which previously had not been known to produce secondary metabolites. The compounds were purified by solid phase extraction and silica gel chromatography followed by preparative HPLC. Among the biological activities the inhibition of fungal germination was th

Abstract is not available

To identify DNA amplifications in sarcomas, comparative genomic hybridization was performed on 27 cases that were likely to display high-level DNA copy number gains. In all cases, chromosome banding analysis had revealed homogeneously staining regions or double minutes, i.e., cytogenetic signs of gene amplification. In most cases, gains predominated over losses. Low-level amplifications (ratio 1.3

Redan romarna anlade fältsjukhus i natursköna områden för att rehabiliteringen skulle fungera bra. Även i modern tid har man uppfört sjukhus i parkmiljöer i syfte att förbättra hälsan hos patienterna. Sjukhusen har gärna utformats så att det är lätt att ta sig ut till de omgivande markerna, fönstren vetter utåt och trädgårdar planeras för att ge patienterna kontakt med naturmiljön. I slutet av 180