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Selenium and breast cancer risk : A prospective nested case-control study on serum selenium levels, smoking habits and overweight

Previous research has not been conclusive regarding the association between selenium (Se) and breast cancer. This study was conducted to clarify if there is an association between prediagnostic serum Se levels and breast cancer risk. A population based cohort, the Malmö Diet and Cancer Study, was used and linked with the Swedish cancer registry up to 31 December 2013. Our study included 1,186 wome

Growth and distributive justice in the Indian agricultural strategies since 1951

The purpose of the following essay is to give a broad outline of the Indian agricultural development and to relate this to two norms of development: growth and distributive justice. Distributive justice is in this context not to be understood as a question of absolute economic equality but should be understood in a broader sense, namely, a relatively egalitarian distribution of incomes and product

Nomograms for preoperative prediction of axillary nodal status in breast cancer

Background: Axillary staging in patients with breast cancer and clinically node-negative disease is performed by sentinel node biopsy (SLNB). The aim of this study was to integrate feasible preoperative variables into nomograms to guide clinicians in stratifying treatment options into no axillary staging for patients with non-metastatic disease (N0), SLNB for those with one or two metastases, and

Surgery and survival in birth cohorts with severe haemophilia and differences in access to replacement therapy : The Malmö experience

Background: Persons with severe haemophilia require lifelong replacement therapy, prophylaxis, to prevent bleeding. Data describing long-term outcomes of prophylactic treatment are scarce. The aim of this study was to investigate joint surgery and survival among persons with severe haemophilia with special attention to access to prophylaxis in the early years of life. Methods: Eligible participant

Perspektiv på svenskt uttal : Fonologi, brytning och didaktik

Att lära sig uttalet i ett nytt språk är för många ett mödosamt arbete. Det gäller att kunna urskilja och producera allt ifrån ljud­segment till enskilda ord och prosodiska element, att få grepp om olika uttalsvarianter och förstå relationen mellan uttal och stavning. För att nå bästa tänkbara resultat för sina individuella uttalsmål behöver inläraren ofta professionell handledning och explicit un

HER2 and EGFR amplification and expression in urothelial carcinoma occurs in distinct biological and molecular contexts

We analyzed a cohort of 599 cases of urothelial carcinoma for EGFR, ERBB2, and ERBB3 gene expression and genomic alterations. The cohort consisted of a reference set (n = 292) comprising all stages and grades and one set (n = 307) of advanced tumors. All cases were previously classified into urothelial carcinoma molecular subtypes. Genomic amplifications were established by array-CGH or in-situ hy

Spädbarnsbotulism - Skäl att inte ge honung till barn under ett år

Infant botulism means that Clostridium botulinum colonize and produce toxin in the infant gut, usually during the first year of life. Illness severity varies widely and the incidence may be under-estimated. Infant botulism should be considered in cases of acute muscle weakness or floppiness in infants, especially when accompanied by constipation or feeding difficulties. Respiratory failure and nee

Infusional Therapies, Continuous Dopaminergic Stimulation, and Nonmotor Symptoms

Pump-based Parkinson (PD) therapies, including subcutaneous apomorphine infusion (CSA) and levodopa-carbidopa intestinal gel (LCIG), presently constitute the most effective pharmacological treatments available for advanced PD. These therapies are based on a more constant delivery of the dopaminergic drug resulting in a more continuous dopaminergic stimulation and a more stable treatment effect. Th

The Montreal Cognitive Assessment : Normative Data from a Large Swedish Population-Based Cohort

Background: The Montreal Cognitive Assessment (MoCA) has a high sensitivity for detecting cognitive dysfunction. Swedish normative data does not exist and international norms are often derived from populations where cognitive impairment has not been screened for and not been thoroughly assessed to exclude subjects with dementia or mild cognitive impairment. Objective: To establish norms for MoCA a

Pinning the slipped and contralateral hips in the treatment of slipped capital femoral epiphysis

Purpose To describe and comment on the treatment of the slipped capital femoral epiphysis (SCFE) with pinning and to present the pros and cons of prophylactic pinning of the contralateral hip. Summary Pinning the SCFE aims to fix the epiphysis and prevent further slipping. Some devices allow for further growth and remodeling of the femoral neck post-operatively. This results in maintained femoral

Tillgång till snabb laboratorieanalys vid akut förgiftning ger bättre och säkrare vård

The Swedish Poisons Information Centre, a nationwide 24/7 service to healthcare providers and the public, answers many questions about serious cases of acute poisoning. In some of these, prompt and proper treatment recommendations can be crucial for the clinical outcome. In cases where self-reported information is missing or considered unreliable, more emphasis is placed on the clinical symptoms a

Description of a reproducible anatomically based surgical algorithm for detection of pelvic sentinel lymph nodes in endometrial cancer

Objective: To describe and evaluate a reproducible, anatomically based surgical algorithm, including reinjection of tracer to enhance technical success rate, for detection of pelvic sentinel lymph nodes (SLNs) in endometrial cancer (EC). Methods: A prospective study of 102 consecutive women with high risk EC scheduled for robotic surgery was conducted. Following cervical injection of a fluorescent

Signaling via Smad2 and Smad3 is dispensable for adult murine hematopoietic stem cell function in vivo

Transforming growth factor-β (TGFβ) is a member of a large family of polypeptide growth factors. TGFβ signals mainly through the intracellular proteins Smad2 and Smad3, which are highly similar in amino acid sequence identity. A number of studies have shown that these proteins, dependent on context, have distinct roles in the TGFβ signaling pathway. TGFβ is one of the most potent inhibitors of hem

Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes : In search of the culprit allergen

Background: During rubber vulcanization, new compounds can be formed. Objectives: To report a case of allergic shoe dermatitis in which the search for the allergen ultimately led to the identification of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). Methods: A female presented with eczema on her feet after wearing Sperry Top Sider® canvas sneakers. Patch testing was performed with the Europea

A 0-Hour/1-Hour Protocol for Safe, Early Discharge of Chest Pain Patients

Objectives: Guidelines recommend a 0-hour/1-hour high-sensitivity cardiac troponin T (hs-cTnT) diagnostic strategy in acute chest pain patients. There are, however, little data on the performance of this strategy when combined with clinical risk stratification. We aimed to evaluate the diagnostic accuracy of an accelerated diagnostic protocol (ADP) using the 0-hour/1-hour hs-cTnT strategy together

Growth The Missing Ingredient of Immigrant Entrepreneurship

This thesis muses the question; how do we understand firm growth in immigrant owned firms? Two literature streams are proposed to be relevant. Firstly, theimmigrant entrepreneurship field, which is developing and becoming increasinglysophisticated. Though despite appeals from within the field, that we need a widerspan of concepts to explain the changing heterogeneity and fabric of immigrantentrepr

Multiple scattering by a collection of randomly located obstacles Part III: Theory - slab geometry

In this paper, scattering of electromagnetic waves by discrete, randomly distributed objects inside a (finite thickness or semi-infinite) slab is addressed.In general, the non-intersecting scattering objects can be of arbitrary form, material and shape with a number density of $n_0$ (number of scatterers per volume).The main aim of this paper is to calculate the coherent reflection and transmissio