Fibrogenic processes instigate fatal chronic diseases leading to organ failure and death. Underlying biological processes involve induced massive deposition of extracellular matrix (ECM) by aberrant fibroblasts. We subjected diseased primary human lung fibroblasts to an advanced three-dimensional phenotypic high-content assay and screened a repurposing drug library of small molecules for inhibitin

The many forms of vasculitis are characterized by inflammation of blood vessels, leading to potentially long-term sequelae including vision loss, aneurysm formation and kidney failure. Accurate estimation of the incidence and prevalence has been hampered by the absence of reliable diagnostic criteria and the rarity of these conditions; however, much progress has been made over the past two decades

Purpose: This paper explores the idea of the prudent entrepreneurial self, through re-conceptualizing prudence into the domain of entrepreneurial education, to unite the two processes of becoming enterprising and entrepreneurial. It is argued that developing a capacity for prudence among graduates involves past, present and conjecture forms of knowledge that the authors find in the interplay betwe

This thesis is dedicated to the investigation of laser-plasma particle acceleration concepts. Some of the work was focused on improving electron and proton acceleration for future applications, in terms of maximizing the particle energy and minimizing the divergence of the X-ray beams. In laser wakefield acceleration, a very intense laser pulse (> 1018 W/cm2) is focused in a gas. The leading edge

INTRODUCTION: Primary graft dysfunction (PGD) is a leading cause of 30-day mortality following heart transplantation, and early intervention in PGD may correlate to improved survival. Our analysis aimed to determine the feasibility of measuring cardiac biomarkers from the donor heart in the early phase for use as a predictor of PGD.METHODS: Blood samples from the coronary sinus were obtained at th

In order to improve the energy efficiency in district heating networks and the comfort of their customers, these networks need to overcome the problem of unfair heat distribution under heat deficits. This paper introduces a new strategy to achieve this thermal fairness objective: it is lowcost in terms of communication and computation. The proposed approach is illustrated on a simulation example.

Since the 2008 financial crisis, more and more states have started to “sell” citizenships and residence permits to the global economic elite in return for investments. This trade is mediated by transnational firms in the investment citizenship industry, who help governments design and reform the programmes, and assist the wealthy in applying for them. The objective of this article is to explore th

This study aimed to describe the incidence of Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based retrospective cohort study of all episodes of SBSEC-bacteremia from 2003 to 2018 in Skåne Region, Sweden. Subspecies was determined by whole-genome sequencing. Medi

The purpose of this editorial is to share our Editorial Board’s Position Statement on Diversity, Equity, and Inclusion (DEI) and provide some of the background behind it, the process of creating it, and the journey from here.

Many of today’s software systems are created by leveraging ecosystems consisting of heterogeneous “complementors” and “hub” firms. In fact, the reliance on ecosystems is prevalent in the enterprise resource planning (ERP) domain, where larger ERP vendors form collaborative relationships with smaller industry-specific vendors to co-create value for themselves and their customers. However, value cre

Förord till Johan Nordström: Föredrag om Sigfrid Aronus Forsius hållet vid Lärdomshistoriska samfundets årsmöte i Rikssalen 12/5 1935

This article argues that the increasing use of press images around 1900 contributed to the construction of the political persona of the British Statesman Joseph Chamberlain. These images fused scenes from his public and private life and, paradoxically, the new focus on his private characteristics reinforced his public role. His private life did not replace his public side, nor was the private unre