Background: T1D and AITD are autoimmune disorders commonly occurring in the same family and even in the same individual. The genetic contribution to these disorders is complex making uncovering of susceptibility genes very challenging. The general aim of this study was to identify loci and genes contributing to T1D/AITD susceptibility. Our strategy was to perform linkage and association studies in

Atomic spectral lines from different isotopes display a small shift in energy, commonly referred to as the line isotope shift. One of the components of the isotope shift is the field shift, which depends on the extent and the shape of the nuclear charge density distribution. The purpose of this work is to investigate how sensitive field shifts are with respect to variations in the nuclear size and

Background: Synaptic degeneration is a central pathogenic event in Alzheimer's disease that occurs early during the course of disease and correlates with cognitive symptoms. The pre-synaptic vesicle protein synaptotagmin-1 appears to be essential for the maintenance of an intact synaptic transmission and cognitive function. Synaptotagmin-1 in cerebrospinal fluid is a candidate Alzheimer biomarker

I över ett och ett halvt år har Riksbanken hållit styrräntan negativ. När lågkonjunkturen kommer har Riksbanken knappast något vapen kvar för att möta denna, skriver forskarna Fredrik NG Andersson och Lars Jonung.

This paper investigates whether the exports of different products by the same firm are systematically interconnected. Using Swedish firm-registry data from 1997-2011, I first document that the distribution of firm export sales is skewed towards their best performing products (‘superstars’). I then use a novel instrumental variable approach to identify if the ‘superstar’ products induce more trade This paper investigates whether the exports of different products by the same firm are systematically interconnected. Using Swedish firm-registry data from 1997-2011, I first document that the distribution of firm export sales is skewed towards their best performing products (‘superstars’). I then use a novel instrumental variable approach to identify if the ‘superstar’ products induce more trade

Patients with rheumatoid arthritis (RA) and other inflammatory joint disorders (IJD) have increased cardiovascular disease (CVD) risk compared with the general population. In 2009, the European League Against Rheumatism (EULAR) taskforce recommended screening, identification of CVD risk factors and CVD risk management largely based on expert opinion. In view of substantial new evidence, an update

Platelets are known to play an important role in acute pancreatitis (AP) via promotion of neutrophil accumulation, although mechanisms behind platelet-dependent accumulation of neutrophils in the pancreas remain elusive. Platelets contain a wide spectrum of different pro-inflammatory compounds, such as chemokines. CXCL4 (platelet factor 4) is one of the most abundant chemokine in platelets, and we

In the development of transdermal and topical products it is important to understand how formulation ingredients interact with the molecular components of the upper layer of the skin, the stratum corneum (SC), and thereby influence its macroscopic barrier properties. The aim here was to investigate the effect of two commonly used excipients, transcutol and dexpanthenol, on the molecular as well as

Scatterer size estimation is useful when characterizing tissue using ultrasound. In all previous studies on scatterer size, the estimations are performed in the frequency domain and are thus subjected to a trade off in time-frequency resolution. This study focused on the feasibility of estimating scatterer size in the time domain using only the ultrasound center frequency, assuming a Gaussian-shap

Monte Carlo simulation is a useful technique to propagate uncertainty through a quantitative model, but that is all. When the quantitative modelling is used to support decision-making, a Monte Carlo simulation must be complemented by a conceptual framework that assigns a meaningful interpretation of uncertainty in output. Depending on how the assessor or decision maker choose to perceive risk, the

Background: Breast cancer is the leading cause of female cancer in Europe and is estimated to affect more than one in 10 women. Higher socioeconomic status has been linked to higher incidence but lower case fatality, while the impact on mortality is ambiguous. Methods: We performed a systematic literature review and meta-analysis on studies on association between socioeconomic status and breast ca

Noninvasive localization of the accessory pathway (AP) in patients with the Wolff-Parkinson-White syndrome and of the site of origin of ventricular tachycardia (VT) is reviewed. 12-lead electrocardiography (ECG) is the most readily available method for localization of both the AP and the site of VT origin. Many published ECG criteria are introduced. The application of body surface potential mappin

Eight sets of electrocardiographic (ECG) criteria for the localization of accessory conduction pathway (ACP) were evaluated on 182 patients with a single ACP. The Rosenbaum criteria identified 78.6% of the left-sided and 94.0% of the right-sided ACPs. Four of the other seven sets of criteria demonstrated a sensitivity higher than 70.9% and six showed a specificity higher than 74.9% in the 4-region

One hundred and thirty-four cases of Wolff-Parkinson-White syndrome were studied to evaluate the relative usefulness of electrocardiography (ECG), electrophysiological studies (EPS), body surface mapping (BSM), gated blood-pool phase analysis (nuclear studies), and vectorcardiography (VCG) in the localization of the accessory pathway (ACP). In comparison with the final localization verified by int

Background. Prevalence of childhood anxiety disorders at specific ages and genetic etiological influences on anxiety disorders in young children have been little studied. The present study reports prevalence estimates in a community sample of 6-year-old twins, and patterns of genetic and environmental influences on these early-onset anxiety disorders. Method. Using a two-phase design 4662 twin-pai

Background: From middle childhood onwards, substantial evidence points to phenotypic differentiation between anxiety diagnostic categories such as generalised anxiety, separation anxiety, specific phobia, and obsessive-compulsive disorders. However, little is known about the genetics of these categories and especially about the phenotypic and genetic structure of related behaviours in pre-school c

The Mississippi Scale for Combat-Related PTSD is widely used in the assessment of post-traumatic stress disorder (PTSD). The high face-validity of the scale may make it vulnerable to faking however. The present study found that the scores of individuals instructed to respond 'as if' they had PTSD did not differ from the scores of veterans with PTSD. Furthermore, although veterans who were diagnose

There are important applied and theoretical reasons for research into the association between social desirability and self-reported anxiety in young people. The aim of this study was to examine the relationship between anxiety and social desirability in a large normative sample of 7- to 14- year-olds (N = 1,786). Participants Completed the Revised Children's Manifest Anxiety Scale and their teache

This study investigated the characteristics of each of the specific DSM- III-R (American Psychiatric Association, 1987) anxiety disorders in a clinic sample of 188 anxiety disordered children. Characteristics examined included sociodemographic variables (age-at-intake, gender, and race of the child, and family marital and socioeconomic status) and clinical variables (disorder age-at-onset and seve