The onset of the Holocene was associated with a global temperature increase, which led to a rise in sea levels and isolation of the last surviving population of woolly mammoths on Wrangel Island. Understanding what happened with the population's genetic diversity at the time of the isolation and during the ensuing 6000 years can help clarify the effects of bottlenecks and subsequent limited popula

Tropical forests of Central and South America represent hotspots of biological diversity. Tree squirrels of the tribe Sciurini are an excellent model system for the study of tropical biodiversity as these squirrels disperse exceptional distances, and after colonizing the tropics of the Central and South America, they have diversified rapidly. Here, we compare signals from DNA sequences with morpho

BACKGROUND: After over a decade of developments in field collection, laboratory methods and advances in high-throughput sequencing, contamination remains a key issue in ancient DNA research. Currently, human and microbial contaminant DNA still impose challenges on cost-effective sequencing and accurate interpretation of ancient DNA data.RESULTS: Here we investigate whether human contaminating DNA

Optimization of vehicle maneuvers using dynamic models in constrained spaces is challenging. Homotopic optimization, which has shown success for vehicle maneuvers with kinematic models, is studied in the case where the vehicle model is governed by dynamic equations considering road-tire interactions. This method involves a sequence of optimization problems that start with a large free space. By it

In October 2023, Claudia Goldin, professor at Harvard University, was awarded the Nobel Prize in Economic Sciences, in recognition of her pioneering contributions to economics, particularly for her in-depth analysis of women’s place in the labor market. Goldin explored the evolution of women’s income and participation in the labor market over the long term, highlighting the causes of these changes

The potential of additional steering possibilities (like rear-wheel or all-wheel steering) is analyzed for critical situations to investigate possible safety improvements. For this purpose, a dynamic optimization problem is formulated to find the best possible maneuver. The optimization criterion is to maximize the entry speed into a constant radius 90°-curve. The optimization problem is solved fo

The objective of this article is to study the links between the funding of primary education, access to education and economic growth in France in the 19th century. To do this, we use information on the funding allocated by the state, départements, local authorities, and households over the period 1820-1913. Our analysis consists of two stages. Firstly, we analyse the evolution of these different

Research comparing equal and expanding spacing schedules in relation to L2 single words is limited. Moreover, none of the existing studies has examined the learning of formulaic language. The current study aims to address this gap by investigating the impact of equal and expanding intervals on the long-term retention of L2 collocations in deliberate learning contexts. Eighty-three university learnResearch comparing equal and expanding spacing schedules in relation to L2 single words is limited. Moreover, none of the existing studies has examined the learning of formulaic language. The current study aims to address this gap by investigating the impact of equal and expanding intervals on the long-term retention of L2 collocations in deliberate learning contexts. Eighty-three university learn

The relationship between the evolutionary dynamics observed in contemporary populations (microevolution) and evolution on timescales of millions of years (macroevolution) has been a topic of considerable debate. Historically, this debate centers on inconsistencies between microevolutionary processes and macroevolutionary patterns. Here, we characterize a striking exception: emerging evidence indic

Metabolic dysfunction-associated steatohepatitis (MASH) is a common but frequently unrecognized complication of obesity and type 2 diabetes. The association between these conditions is multifaceted and involves complex interactions between metabolic, inflammatory, and genetic factors. Here we assess the underlying structural and molecular processes focusing on the immunological phase of MASH in th

Agriculture has been dominated by annual plants, such as all cereals and oilseeds, since the very beginning of civilization over 10,000 years ago. Annual plants are planted and uprooted every year which results in severe disturbance of the soil and disrupts ecosystem services. Science has shown that it is possible to domesticate completely new perennial grain crops, i.e. planted once and harvestedNon-technical summary:Agriculture has been dominated by annual plants, such as all cereals and oilseeds, since the very beginning of civilization over 10,000 years ago. Annual plants are planted and uprooted every year which results in severe disturbance of the soil and disrupts ecosystem services. Science has shown that it is possible to domesticate completely new perennial grain crops, i.e. plan

Monitoring the spatial distribution and trends in surface greenhouse gas (GHG) fluxes, as well as flux attribution to natural and anthropogenic processes, is essential to track progress under the Paris Agreement and to inform its global stocktake. This study updates earlier syntheses (Petrescu et al., 2020, 2021, 2023), provides a consolidated synthesis of CH4 emissions using bottom-up (BU) and to

BackgroundThe primary aim of specialised palliative care (SPC) is to improve the quality of life (QoL) for patients with a high symptom burden from a life-threatening disease. This randomised study aimed to assess the QoL impact of early integration of SPC alongside tumour-specific palliative treatment in patients with gastrointestinal (GI) cancers.MethodsWe randomly assigned ambulatory patients w