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Problems associated with the determination of heterocyclic amines in cooked foods and human exposure.

Epidemiological studies have shown diet to be an important factor in the global variation of human cancer rates. The presence of mutagenic/carcinogenic heterocyclic aromatic amines (HAs) in cooked foods has attracted a great deal of interest for more than 20 years. Accurate assessment of the human exposure to HAs requires food questionnaires that address cooking methods and reliable methods for th

On Development and Characterisation of Continuous Ink Jet Nozzles

This thesis concerns nozzles and their impact on droplet formation and droplet flight in a continuous ink jet printer. Methods are suggested to characterise droplet formation and droplet flight stability (D.F.S.). A study about the influence of droplet flight stability on the quality of print out is presented. A method to assess the charging process for the continuous ink jet is described. The dev

Propagation characteristics of polarized radio waves in cellular communications

Narrowband and wideband measurements of the radio channel using different combinations of transmit and receive polarization have been performed. The measurements cover a range of scenarios including urban, suburban and open terrain, as well as both outdoor and indoor terminals. The vertical-to-vertical (V-V) and horizontal-to-horizontal (H-H) polarization combinations are found to provide equal re

Targeting the human papillomavirus for prevention of cervical cancer

Popular Abstract in Swedish Varje år insjuknar ungefär 450 000 kvinnor i livmoderhalscancer (cervixcancer) i världen. Som en följd av screening för livmoderhalscancer, där kvinnor testar sig regelbundet för cellförändringar, har insjuknandet i livmoderhalscancer minskat. Det cellprov som används i screeningen lyckas dock inte upptäcka alla kvinnor som har ökad risk för framtida cancer. Humant papiDifferent types of human papillomavirus (HPV) vary in the extent they cause precursor lesions (CIN) and cancer. There are limited long-term efficacy data on HPV testing in primary screening Among 72 cervical cancers in Mozambique, HPV 16 and 18 were the most frequent HPV types (69% of cases). Comparing 108 cervical cancers cases and 517 matched controls nested within a population-based cohort in

Effects of hardened wood ash on microbial activity, plant growth and nutrient uptake by ectomycorrhizal spruce seedlings

Plant growth, nutrient uptake, microbial biomass and activity were studied in pot systems containing spruce seedlings colonised with different ectomycorrhizal fungi from an ash-fertilised forest. The seedling root systems were enclosed in mesh bags inside an outer compartment containing crushed, hardened wood ash. Three different species of mycorrhizal fungi and a non-mycorrhizal control were expo

Blunt renal trauma. Analysis of 417 patients

Case records of 417 patients, from a well-defined area, who were hospitalized because of blunt renal trauma during the period 1950-1979 were analyzed. The incidence increased during the final decade, corresponding to a rising incidence of motor traffic accidents and sports injuries. Young patients, between 10 and 29 years of age, were responsible for the increase and half of all patients were in t

Oesophageal dysmotility, delayed gastric emptying and gastrointestinal symptoms in patients with diabetes mellitus.

Aims Gastroparesis is a common gastrointestinal complication in diabetes mellitus, whereas dysfunction in the other gastrointestinal organs has been less thoroughly investigated. Furthermore, it is not known whether there is any relationship between motility and dysmotility between these organs. The aim of this study was to examine whether diabetic patients with gastrointestinal symptoms also have

Fundamental effects and non-linear Si detector response

Non-linearity in the energy response of a Si p-i-n charged particle detector has been studied for incident particles with Z(1) between 3 and 26, and energies between 0.1 and 0.7 MeV per nucleon. Although the data closely followed a straight line relations, fitting of the data to a third order polynomial revealed that the response exhibited a persistent curvature that acted to reduce the energy int

OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(-/-) mice aortas

Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in a

Impact and risk factors for early-onset group B streptococcal morbidity: analysis of a national, population-based cohort in Sweden 1997-2001

Objectives To study early-onset group B streptococcal (EOGBS) morbidity, mortality, and maternal risk factors. Design Observational, population-based, retrospective. Data from national registers and medical records. Setting Sweden, 1997-2001. Population Cohort of 640 infants with a diagnosis of GBS infection out of 435 070 live births. Method Infants with diagnoses GBS sepsis (P36.0) and/or pneumo

Development of separation technique for stem cells

In recent years, human embryonic stem cells have been established, and somatic stem cells derived from various adult organs have been identified and characterized to differentiate into various kinds of functional cells. There have been attempts to use functional cells induced from such stem cells for tissue regeneration and cell therapy. The method is expected to become an important treatment for

Graft repair of a peripheral nerve without the sacrifice of a healthy donor nerve by the use of acutely dissociated autologous Schwann cells.

We hypothesised that pieces of nerve that are normally trimmed away during graft repair could be a source of Schwann cells and used to create an autologous cell-containing nerve graft. To test the idea a transsection injury was made on the rat sciatic nerve. Seven days later, pieces from the proximal and distal stumps were used for the immediate isolation of its non-neuronal cells. These cells, of

The influence of refugial population on Lateglacial and early Holocene vegetational changes in Romania

Romania has for a long time been lacking good palaeoenvironmental records, particularly for the Late Quaternary. A chronological framework had been nearly absent and the vegetation development had been reconstructed entirely from pollen data. Data sets from this part of Europe are important for assessing the spatial variability of past vegetation and climatic changes and to reconstruct tree migrat

Prostate cancer screening decreases the absolute risk of being diagnosed with advanced prostate cancer - Results from a prospective, population-based randomized controlled trial

Objectives: Randomized controlled trials are currently conducted to assess whether the mortality from prostate cancer is reduced by early detection with the use of prostate-specific antigen (PSA) measurements in serum. To be effective, such a program should be able to reduce the absolute number of men diagnosed with metastatic prostate cancer (for which no cure is available). The aim of the presen

Pooled analysis of prognostic impact of uPA and PAI-I in breast cancer patients

In this report we present an extension of the pooled analysis of the prognostic impact of urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I in breast cancer patients. We analyzed a different endpoint, metastasis-free survival (MFS). We checked the consistency of the estimates for uPA and PAI-I for relapse-free survival (RFS) and MFS exploring possible sources of heterogeneity. Nod