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Tamoxifen (Tam) is widely used in chemotherapy of breast cancer. It inhibits proliferation and induces apoptosis of breast cancer cells by estrogen receptor (ER)-dependent modulation of gene expression. In addition, recent reports have shown that Tam also has nongenomic effects. We previously reported induction of a rapid mitochondrial death program in breast cancer cells at pharmacological concen
We consider the problem of maintaining a string of n brackets '('or')' under the operation reverse(i) that changes the ith bracket from '('to')' or vice versa, and returns 'yes' if and only if the resulting string is properly balanced. We show that this problem can be solved on the RAM in time O(log n/log log n) per operation using linear space and preprocessing. Moreover, we show that this is opt
{2,6-Bis[(di-tert-butylphosphino)methyl]phenyl}palladium hydroxide, PCPPdOH, undergoes a fast insertion of CO2 to give the bicarbonate complex (PCP)PdO2COH. It also reacts with CO to give a mononuclear hydroxy carbonyl complex, (PCP)PdCOOH. The Pd-C bond of this is unreactive toward olefins. The complex undergoes a slow conversion to the formate complex, (PCP)PdO2CH, via a decarboxylation to give
When low calorific value gases are fired, the performance and stability of gas turbines may deteriorate due to a large amount of inertballast and changes in working fluid properties. Since it is rather rare to have custom-built gas turbines for low lower heating value (LHV) operation, the engine will be forced to operate outside its design envelope. This, in turn, poses limitations to usable fuel
Volatiles from chocolate mediate upwind flight behavior in Ephestia cautella and Plodia interpunctella. We used gas chromatography with electroantennographic detection and found 12 active compounds derived from three different chocolate types, i.e., plain, nut-containing, and rum-flavored. Eight of the compounds were identified with mass spectrometry, and the activity of three compounds, ethyl van
The basic electrochemistry of carbon paste electrodes modified with Meldola Blue adsorbed on zirconium phosphate (MB-ZP-CPEs) and their ability to oxidize NADH have been investigated. Three types of carbon powder (graphite and glassy carbon-type Sigradur K and G) were used to obtain MB-ZP-CPEs. On comparing cyclic voltammograms recorded at MB-ZP-CPEs, similarly prepared from the three different ca
Eight variable regions (microsatellites, insertion/deletion and duplication regions) from the plastid DNA genome were analyzed for 91 populations belonging to Dactylorhiza majalis ssp. traunsteineri and closely related taxa. A total of 36 composite plastid haplotypes were found. The two dominating haplotypes had a clear geographic distribution suggesting at least two separate immigration routes in
Introduction In an age when brands have seized the imagination of so many, the corporate landscape has become a brandscape. Recently, corporate branding has emerged as an important agenda item for many senior executives. Brands are viewed as a significant corporate asset. The corporate brand is viewed as an important profile builder for corporations. It is seen as an invaluable tool for attracting
The colonisation intensity and composition of the mycorrhizal community in the aquatic plants Lobelia dortmanna and Littorella uniflora were studied. The mycorrhizal fungi were characterised by fungal specific nested PCR and sequencing using the 5'-end of the LSU rDNA as target. For this, primers for the clade of Acaulospora, the clade including Glomus mosseae and G. intraradices and the clade con
Flow cytometry, morphometry and molecular markers [plastid DNA and internal transcribed spacers(ITS) of nuclear ribosomal DNA] were used to determine taxonomic and phylogeographic patterns in Dactylorhiza maculata s.l. from Scandinavia. A total of 238 individuals from 27 populations from throughout all of Scandinavia, including the adjacent Kola Peninsula of Russia, were analyzed. Diploid D. macul
At present, the climate in south-west Scandinavia is predominantly controlled by westerlies carrying moist Atlantic air, which forms a main source of precipitation in all seasons. Past variations in the ratio between precipitation and evaporation (effective precipitation) from terrestrial sites, however, may indicate changes in the degree of maritime influence. Palaeoclimatic archives in this regi
The purpose of the present study was to compare symptom load in youth groups treated with three Swedish Blueprint programmes - Functional Family Therapy (FFT), Multisystemic Therapy (MST) and Multidimensional Treatment Foster Care (MTFC) - to see if symptom load matches the intensity of the treatment model as expected. These youth groups were also compared with in- and outpatients from child and a
Maternal effects by which females provide their offspring with non-genetic factors such as hormones, nutrients and antibodies can have an important impact on offspring fitness. In vertebrates, maternal antibodies (matAb) are transferred from the mother, via the placenta, egg yolk or milk during lactation to offspring until they are 2 weeks (birds), 4-10 weeks (rodents) and 9 months (humans) old, r
Transforming growth factor-β 1 (TGF-β) regulates cellular functions like proliferation, differentiation, and apoptosis. On the cell surface, TGF-β binds to receptor complexes consisting of TGF-β receptor type II (Tβ RII) and activin-like kinase receptor-5 (Alk5), and the downstream signaling is transduced by Smad and MAPK proteins. Recent data have shown that alternative receptor combinations asid
Alcohols, such as 2,2,2-trifluoroethanol (TFE), have been shown to induce a cooperative transition to an open helical structure in many proteins, but the underlying molecular mechanism has not been identified. Here, we employ the technique of magnetic relaxation dispersion (MRD) to study the TFE-induced transition of -lactoglobulin at pH 2.4. Unlike traditional techniques that focus on protein sec
Background: Serum IgA antibodies against tissue transglutaminase (tTG) are reliable markers for celiac disease (CD), still the diagnostic performance of anti-tTG immunoassays can be improved. A novel ELISA, using fibronectin (FN) as tTG binding protein, was evaluated for the detection of anti-tTG antibodies in CD. Methods: Sera from 173 children with untreated CD and 97 controls were analyzed for
Photofragmentation of argon clusters of average size ranging from 10 up to 1000 atoms is studied using soft x-ray radiation below the 2p threshold and multicoincidence mass spectroscopy technique. For small clusters (N=10), ionization induces fast fragmentation with neutral emission imparting a large amount of energy. While the primary dissociation takes place on a picosecond time scale, the fragm
As a diagnostic of high-intensity laser interactions (> 10(19) W cm(-2)), the detection of radioactive isotopes is regularly used for the characterization of proton, neutron, ion, and photon beams. This involves sample removal from the interaction chamber and time consuming post shot analysis using NaI coincidence counting or Ge detectors. This letter describes the use of in situ detectors to meas
