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Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) represents a growing clinical threat due to convergence of resistance and virulence determinants. We conducted a multicenter genomic epidemiology study analysing CR-hvKp isolates collected from 19 tertiary-care hospitals across Türkiye between 2018 and 2023. CR-hvKp isolates were subjected to whole-genome sequencing to investigate
PurposeTürkiye ranks among the highest in antibiotic consumption within OECD countries and faces growing challenges from multidrug-resistant uropathogens. Nationwide, resistance-guided treatment data remain scarce. The main objective of this work is to provide a comprehensive nationwide data on antibiotic resistance patterns among uropathogens to guide treatment options in urinary tract infections
Background: Inadequate postoperative pain management after lumbar discectomy may delay recovery, increase the risk of chronic pain, and prolong hospitalization. Effective analgesic strategies must balance pain control with minimal adverse effects. Objective: To identify the most effective postoperative analgesic interventions for patients undergoing lumbar discectomy. Databases and Data Treatment:
AimThere is a need for updated reference intervals for iron status biomarkers during infancy. This study aimed to investigate reference interval trends and diurnal variation of iron, transferrin, and transferrin saturation in infants subjected to delayed cord clamping at birth (DCC).MethodsData analysis from population-based Swedish studies, including 362 term-born infants subjected to DCC ≥ 60 s.
Rupture of unstable atherosclerotic plaques is a major cause of mortality. Endothelial-to-mesenchymal transition associates with advanced atherosclerotic plaques and contributes to plaque progression. We examined the role of Twist1, a transcription factor that drives endothelial-to-mesenchymal transition, in plaque progression by inducible deletion from endothelial cells in hypercholesterolemic mi
Background The 2023 European Society of Cardiology (ESC) guidelines for acute coronary syndromes (ACS) maintained a Class III recommendation against routine pretreatment with oral P2Y12 inhibitors in non-ST-segment elevation ACS (NSTE-ACS) and downgraded pretreatment in ST-segment elevation myocardial infarction (STEMI) to Class IIb. This study evaluated real-world uptake of these recommendations
Rapid urban growth is making cities hotter, a trend further exacerbated by climate change. Urban green spaces (UGS) are commonly used as nature-based solutions to reduce heat, but there are gaps in understanding how cooling effects vary across climate zones. Using satellite data from 2021 to 2024, we examined urban heat and UGS patterns during the hot season across four Ethiopian cities with diffe
Bone conduction hearing implant systems (BCHIs) are established treatments for patients with conductive or mixed hearing loss or single-sided deafness when conventional hearing aids are unsuitable. This study evaluated the cost-effectiveness of the active transcutaneous system Sentio versus a similar system, i.e., Osia in an Australian setting. Scenario analyses also compared Sentio to other syste
Immersive visual environment can deceive our interoceptive perception of how we move relative to our environment. If the visual environment or a high reliance on vision produces straining work conditions, motion sickness or is associated with a medical disorder, the causes merit addressing. Therefore, the purpose of this study was to investigate whether postural control adapts to challenging visua
Purpose: To investigate factors guiding follow-up imaging after hospital discharge in atraumatic intracerebral hemorrhage (ICH) across large European academic centers and compare decision-making patterns using a standardized approach. Methods: Expert neuroradiologists from nine European centers in eight countries detailed their follow-up algorithms for deep and lobar ICH, specifying (1) patient-re
Industrial Control Systems (ICS) have been compromised by cyber-attacks with the development of computer and network technologies over the past few decades. Intrusion Detection Systems (IDSs) play a significant role in ensuring information security, and the key mechanism is to identify various attacks in the network accurately. One common strategy when implementing an IDS is to use a machine-learn
Reducing greenhouse gas emissions and achieving carbon neutrality require enhancing spark-ignition engine efficiency and compatibility with renewable fuels. However, electrode wear of spark plugs presents a significant challenge in hydrogen-fueled spark-ignition internal combustion engines. Such excessive wear increases the total cost of ownership and may delay the introduction of such low-emissio
Whereas a considerable literature emphasizes the role and function of municipalities and regions in the European Union (EU) as an expression of multilevel governance, a parallel literature has emerged which projects a view of the EU as an example of multilevel administration. This latter literature directs attention towards emerging vertical linkages implying new chains of accountability and
Background: The incidence of pancreatic cancer (PC) and autoimmune diseases (ADs) has been increasing worldwide. While certain associations between specific ADs, such as pancreatitis, and PC have long been well confirmed, population-focused research investigating the broader spectrum of ADs and their relationship with PC risk remains limited. Methods: We implemented a cohort study based on populat
The chemical abundances of stars in galaxies are a fossil record of the star formation and stellar evolution processes that regulate galaxy formation, including the stellar initial mass function, the fraction and timing of type Ia supernovae (SNeIa), and nucleosynthesis inside massive stars. In this paper, we systematically explore uncertainties associated with modeling chemical enrichment in dwar
Contrasting predominant assumptions of women who live with age-related care needs as passive, unagentic, and helpless, this article explores agency exercised in everyday lives permeated by formal home care services. Using a narrative thematic analysis of interviews, diaries, and observations of three Swedish women in later life using home care services, this study examines their diverse ways of na
Recension av Claes Rosenqvist (2026), På de små scenerna – Carl Pfeiffer 1849–1909.
IntroductionMidwifery knowledge, education and training in practice are challenged in contemporary maternity care by the growing trend towards interventions during childbirth, a dominant risk perspective and medicalised care. There is an ongoing debate about the definition of normal birth, however, midwives continue to advocate for normal birth.ObjectiveTo explore midwives’ views and definitions o
Social mobility can theoretically have an independent impact on fertility. The problem is empirically assessing it, as mobility is a function of both social origin and destination. This paper presents the Diagonal Reference Model (DRM) as a valuable historical method to study social mobility consequences. We use Swedish individual-level longitudinal data with intergenerational links covering 1905
