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Thorough analysis of unorthodox ABO deletions called by the 1000 Genomes project

BACKGROUND AND OBJECTIVES: ABO remains the clinically most important blood group system, but despite earlier extensive research, significant findings are still being made. The vast majority of catalogued ABO null alleles are based on the c.261delG polymorphism. Apart from c.802G>A, other mechanisms for O alleles are rare. While analysing the data set from the 1000 Genomes (1000G) project, we encou

Achievable Rates and Training Overheads for a Measured LOS Massive MIMO Channel

This paper presents achievable uplink (UL) sum-rate predictions for a measured line-of-sight (LOS) massive multiple-input, multiple-output (MIMO) (MMIMO) scenario and illustrates the trade-off between spatial multiplexing performance and channel de-coherence rate for an increasing number of base station (BS) antennas. In addition, an orthogonal frequency division multiplexing (OFDM) case study is

Light meson gas in the QCD vacuum and oscillating universe

We have developed a phenomenological effective quantum-field theoretical model describing the "hadron gas" of the lightest pseudoscalar mesons, scalar σ-meson and σ-vacuum, i.e. the expectation value of the σ-field, at finite temperatures. The corresponding thermodynamic approach was formulated in terms of the generating functional derived from the effective Lagrangian providing the basic thermody

The Gaia-ESO Survey : Churning through the Milky Way

Context. There have been conflicting results with respect to the extent that radial migration has played in the evolution of the Galaxy. Additionally, observations of the solar neighborhood have shown evidence of a merger in the past history of the Milky Way that drives enhanced radial migration. Aims. We attempt to determine the relative fraction of stars that have undergone significant radial mi

Designing optimal sampling schemes

In this work, we propose a method for finding an optimal, non-uniform, sampling scheme for a general class of signals in which the signal measurements may be non-linear functions of the parameters to be estimated. Formulated as a convex optimization problem reminiscent of the sensor selection problem, the method determines an optimal sampling scheme given a suitable estimation bound on the paramet

Developing a regional superbus concept - collaboration challenges

The 2014 Swedish National infrastructure plan allocated funds to implement a “Regional Superbus concept”. The concept involves the upgrading a number of existing regional express bus services to make them function as an alternative to investing in regional rail. The Regional superbus concept is an attempt to adapt the BRT planning philosophy to the regional scale and the context of the region it s

Social Assistance and Mental Health: Evidence from Longitudinal Data on Pharmaceutical Consumption

This paper examines the short-term effect between take-up of Social Assistance Benefit (SAB) and mental health. Using a panel dataset including rich yearly register data on e.g. income, income sources, unemployment and types of pharmaceutical consumption for over 140,000 Swedes 2006-2012, we quantify the importance of the psychosocial dimensions (e.g. shame and guilt) of the socioeconomic status –

Stock Market Returns and Consumption

This paper employs Swedish data on households' stock holdings to investigate how consumption responds to changes in stock market returns. We instrument the actual capital gains and dividend payments with past portfolio weights. Unrealized capital gains lead to a marginal propensity to consume (MPC) of 13 percent for the bottom 50% of the wealth distribution, but a flat 5 percent for the rest of th

Opening Hours Decision and Competition in the Motor Vehicle Inspection Market

This paper examines the effect of competition on a firm's choice of opening hours in the motor vehicle inspection market. Competition affects the incentive inspection firms face when choosing opening hours, which influences the probability that consumers find service time that best matches their preferred time. We use 2SLS analyses to resolve the potential endogeneity of market entry decisions. Us

Competition Makes Inspectors More Lenient: Evidence from the Motor Vehicle Inspection Market

We examine the impact of competition on a firm's incentive to relax the standards of its inspection to its customers in the Swedish motor vehicle inspection market, which is heavily regulated and consciously designed to mitigate incentives to deviate from the regulation. We use a panel dataset representing 22.5 million car roadworthiness tests during the period 2010--2015. Fixed effects and instru

Evolutionary Selection against Iteratively Weakly Dominated Strategies

This paper provides sufficient conditions under which convex monotonic evolutionary dynamics (a class of imitative dynamics that includes the replicator dynamic) select against strategies that do not survive iterated elimination of weakly dominated strategies. We apply these conditions to Bertrand duopolies, first-price auctions, finitely repeated Prisoner's Dilemmas, and the p-Beauty Contests. Ou

High-Speed Broadband and Academic Achievement in Teenagers: Evidence from Sweden

This study examines the effects of super-fast internet connections on the academic achievement of students in upper secondary school. We link detailed register data on around 250,000 students to local levels of access to optic fiber broadband, in order to estimate a causal effect of broadband on student GPA. We show that reaching full coverage in the student’s parish of residence causes a GPA redu

Intra-African movements of the African cuckoo Cuculus gularis as revealed by satellite telemetry

Despite many bird species migrating regularly within the African continent, in response to rainfall and breeding opportunities, documented evidence of the spatiotemporal patterns of such movements is scarce. We use satellite telemetry to document the year round movement of an intra-African migrant breeding in the savannah zone of sub-Saharan Africa, the African cuckoo. After breeding in central Ni

Signal reconstruction with generalized sampling

This paper studies the problem of reconstructing continuous-time signals from discrete-time uniformly sampled data. This signal reconstruction problem has been studied by the authors in various contexts, and led to a new signal processing paradigm. The crux there is to employ a physically realizable signal generator model, and design an (sub)optimal filter via H-infinity (C+) optimal sampled-data

Increased endothelin-1-mediated vasoconstriction after organ culture in rat and pig ocular arteries can be suppressed with MEK/ERK1/2 inhibitors

PURPOSE: Even though retinal vascular changes following ischaemia have been poorly understood, the upregulation of vasoconstrictive endothelin-1 (ET-1) receptors (ETA/ETB) following global cerebral ischaemia has been described. The aim of this study was to investigate whether or not the MEK/ERK1/2 pathway is involved in the observed upregulation and whether specific MEK/ERK1/2 inhibitors U0126 and