Extensive research has demonstrated a tumor-promoting role of increased WNT5A expression in malignant melanoma. However, very little light has been shed upon how WNT5A expression is up-regulated in melanoma. A potential regulator of WNT5A expression is the pro-inflammatory cytokine Interleukin (IL)-6, which shares the ability of WNT5A to increase melanoma cell invasion. Here, we investigate whethe

Layered cobalt oxides have been shown to be highly active catalysts for the oxygen evolution reaction (OER; half of the catalytic "water splitting" reaction), particularly when promoted with gold. However, the surface chemistry of cobalt oxides and in particular the nature of the synergistic effect of gold contact are only understood on a rudimentary level, which at present prevents further explor

We investigate the dynamics of kinetically frozen block copolymer micelles of different softness across a wide range of particle concentrations, from the fluid to the onset of glassy behavior, through a combination of rheology, dynamic light scattering, and pulsed field gradient NMR spectroscopy. We additionally perform Brownian dynamics simulations based on an ultrasoft coarse- grained potential,

Aims/hypothesis Insulin autoantibodies (IAA) are important in type I diabetes risk assessment. However, their determination varies more between laboratories than other diabetes autoantibodies. The Diabetes Antibody Standardization Program (DASP) aims to improve and standardise measurement of autoantibodies associated with type I diabetes. We report the results of measurement of IAA from DASP works

Homogeneous charge compression ignition (HCCI) presents new challenges in combustion phasing control due to the lack of direct ignition trigger. In addition, recompression HCCI possesses cycle-to-cycle coupling through trapping a large portion of the exhaust gas in the cylinder. This paper examines the change in the cycle-to-cycle coupling around different operating points in recompression HCCI an

We suggest one of the possible ways to compensate the large negative quantum-topological QCD contribution to the vacuum energy density of the Universe by means of a positive constant contribution from a cosmological Yang-Mills field. An important role of the exact particular solution for the Yang-Mills field corresponding to the finite-time instantons is discussed. An interesting connection of the

The aim of the study was to establish whether the duration of anticoagulant (AC) therapy can be tailored, on an objective basis, by using ventilation/perfusion single-photon emission computed tomography (V/P SPECT) and to assess the extent of residual perfusion defects over time. In particular, we addressed the following: (a) is the extent of perfusion recovery at 3 months of initial pulmonary emb

Most patients with acute pulmonary embolism (PE) are still treated as inpatients. This is a retrospective cohort study of patients with acute PE, diagnosed using V/P SPECT between 2007 and 2011. Patients were treated at home if they were hemodynamically stable, did not require oxygen or parenteral analgetics, had no contraindications to anticoagulant treatment and V/P SPECT showed an extension of

BackgroundPreservatives are important and frequent skin sensitizers, found in a wide range of products for personal and occupational use. According to the European legislation, some cosmetic ingredients are restricted in terms of quantity and a detailed list of ingredients must be present on the product or packaging. ObjectivesTo examine the use of preservatives in common cosmetics on the Israeli

Decisions in front of a supermarket shelf probably involve a mix of visually available information and associated memories – and interactions between those two. Several cognitive processes, such as decision-making, search and various judgments, are therefore likely to co-occur, and each process will influence visual attention. We conducted two eye-tracking experiments capturing parts of these feat

Could honeybees' most valuable contribution to mankind besides pollination services be alternative tools against infections? Today, due to the emerging antibiotic-resistant pathogens, we are facing a new era of searching for alternative tools against infections. Natural products such as honey have been applied against human's infections for millennia without sufficient scientific evidence. A uniqu

OBJECTIVE: There is evidence supporting that tumor necrosis factor receptor (TNFR)-signaling can induce production of beta-amyloid (Abeta) in the brain. Moreover, amyloid-induced toxicity has been shown to be dependent on TNFR-signaling. However, it is still unclear whether TNFRs are involved in the early stages of dementia. METHODS: We analyzed soluble TNFR1 and TNFR2 levels in plasma and cerebro

A Task Group within the ICRP Committees 2 and 3 is continuously working to improve absorbed dose estimates to patients investigated with radiopharmaceuticals. The work deals with reviews of the literature, initiation of new or complementary studies of the biokinetics of a compound and dose estimates. Absorbed dose calculations for organs and tissues have up to now been carried out using the MIRD f

Multiple photoionization of neon atoms by a strong 13.7 nm (90.5 eV) laser pulse has been studied at the FLASH free electron laser in Hamburg. A velocity map imaging spectrometer was used to record angle-resolved photoelectron spectra on a single-shot basis. Analysis of the evolution of the spectra with the FEL pulse energy in combination with extensive theoretical calculations allows the ionizati

Bimetallic catalysts have been synthesised based on Jacobsens C2-symmetric bissalen ligand. They constitute the first examples of compounds with pseuodo-C2 symmetry, owing to the presence of two different metal ions. They have been investigated in the ring-opening of meso-epoxides by trimethylsilyl azide (TMSN3). Pseudo-C2-symmetric [CrIII?Co]bissalen complexes were the best in inducing ee (9394?%

In this study, the impact of coupling and initializing the leaf area index from the dynamic vegetation model Lund-Potsdam-Jena General Ecosystem Simulator (LPJ-GUESS) is analyzed on skill of decadal predictions in the fully coupled atmosphere-land-ocean-sea ice model, the European Consortium Earth System Model (EC-Earth). Similar to the impact of initializing the model with the observed oceanic st

Drugs used for sedation in anesthesia and intensive care may cause pharyngeal dysfunction and increased risk for aspiration. In this study, the authors investigate the impact of sedative doses of morphine and midazolam on pharyngeal function during swallowing and coordination of breathing and swallowing.