Successful use of microgels as delivery systems of antimicrobial peptides (AMPs) requires control of factors determining peptide loading and release to/from the microgels as well as of membrane interactions of both microgel particles and released peptides. Addressing these, we here investigate effects of microgel charge density and conformationally induced peptide amphiphilicity on AMP loading and

Enumeration of circulating tumor cells (CTCs) predicts overall survival and treatment response in metastatic cancer, but as many commercialized assays isolate CTCs positive for epithelial cell markers alone, CTCs with little or no epithelial cell adhesion molecule (EpCAM) expression stay undetected. Therefore, CTC enrichment and isolation by label-free methods based on biophysical rather than bioc

Given that Alcohol Use Disorder (AUD) is clinically heterogeneous, can we, in a large epidemiological sample using public registries, identify clinical features of AUD cases in biological and step-fathers that index, respectively, genetic and familial-environmental risk for AUD in their offspring? From all father-offspring pairs where the father had AUD and the offspring was born 1960–1990, we ide

The aim of this article is to problematize the ways class and gender are played out in adult students’ narratives about their occupational choice and future. Drawing on Beverly Skeggs, we analyse how students think about future occupations, what motivates them towards these and how they are able to form their future in relation to them. Taking on Sweden as a case, our results show that students’ n

Summary: The objective was to estimate the burden of osteoporosis in Sweden based on current clinical practice and the cost-effectiveness of improvements in the management of osteoporosis over the clinical management compared to current clinical practice. Results showed that better compliance to treatment guidelines is associated with better projected outcomes and cost-savings. Introduction: The p

Background: Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks. Objectives: To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culpri

This article aims to mirror a time of radical change in Swedish jazz education through perspectives formulated in the jazz journal Orkesterjournalen. During the 1980s, jazz musicians are still typically viewed as self-taught; you learn how to play jazz through listening and through playing together in contexts where fellow musicians function as informal “teachers”. The growing formal jazz educatio

We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-densitylipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in m

Germline mutations in CDKN2A are frequently identified among melanoma kindreds and are associated with increased atypical nevus counts. However, a clear relationship between pathogenic CDKN2A mutation carriage and other nevus phenotypes including counts of common acquired nevi has not yet been established. Using data from GenoMEL, we investigated the relationships between CDKN2A mutation carriage

utomotive systems offer a rich opportunity for hybrid models, controls, and tools. Beyond the traditional use of hybrid models for representing the behavior of the composition of discrete controller and continuous plants, automotive mechanical systems exhibit hybrid behavior as demonstrated in this chapter. In addition, hybrid systems can be used to capture system specifications at the highest lev

In the last decades, emission legislation on pollutant emissions generated by road transportation sector has become the main driving force for internal combustion engine development. Approximately 20% of worldwide emissions of carbon dioxide from fuel combustion come from the transportation sector, and road vehicles contribute up to 80% of those emissions [1].Light-duty methane gas engines are usuIn the last decades, emission legislation on pollutant emissions generated by road transportation sector has become the main driving force for internal combustion engine development. Approximately 20% of worldwide emissions of carbon dioxide from fuel combustion come from the transportation sector, and road vehicles contribute up to 80% of those emissions [1]. Light-duty methane gas engines are us

Internal combustion engine (ICE) fuel efficiency is a balance between good indicated efficiency and mechanical efficiency. High indicated efficiency is reached with a very diluted air/fuel-mixture and high load resulting in high peak cylinder pressure (PCP). On the other hand, high mechanical efficiency is obtained with very low peak cylinder pressure as the piston rings and bearings can be made wInternal combustion engine (ICE) fuel efficiency is a balance between good indicated efficiency and mechanical efficiency. High indicated efficiency is reached with a very diluted air/fuel-mixture and high load resulting in high peak cylinder pressure (PCP). On the other hand, high mechanical efficiency is obtained with very low peak cylinder pressure as the piston rings and bearings can be made w

I denna rapport presenteras resultaten av den intervjustudie och efterföljande fokusgruppsdiskussion som vi genomfört inom ramen för forskningsprojektet Green Industrial Transitions (GIST, www.gist2050.com). Forskningsprojektets huvudsyfte är att studera förutsättningarna för en omställning till nollutsläpp av koldioxid inom den svenska basindustrin samt analysera strategier, åtgärder och styrmede