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Bisphosphonates for orthopedic applications. Studies in rat models

Popular Abstract in Swedish Denna avhandling undersöker förutsättningarna för att stoppa nedbrytning av benvävnad med hjälp av bifosfonater i några ortopediska problemsituationer. Bifosfonater är en relativt ny grupp av läkemedel som hämmar nedbrytning av benvävnad. De binder effektivt till benmineral och i praktiken förblir de inbundna i skelettet tills benmineralet upplöses. Bifosfonater finns iProsthetic loosening, bone graft resorption and osteonecrosis are examples of problems in orthopedic surgery caused by or augmented by bone resorption. Bone resorption is caused by osteoclasts. Osteoclasts can be inactivated with biphosphonates, a drug in clinical use against osteoporosis and osteolytic tumors. The bone resorption-reducing ability of bisphosphonates was analyzed in rat models. An

Motion Estimation in Image Sequences Using the Deformation of Apparent Contours

The problem of determining the camera motion from apparent contours or silhouettes of curved three-dimensional surfaces is considered. In a sequence of images is shown how to use the generalized epipolar constraint on apparent contours. One such constraint is obtained for each epipolar tangency point in each image pair. Thus in theory the motion can be calculated from the deformation of a single c

“Outside” directors in SME boards: a call for theoretical reflections

Good governance for SMEs is critical for economic development and growth in both developed and developing economies. In this paper we focus on boards and governance in small and medium sized enterprises (SMEs) by investigating the role and contribution of “outside” directors in this setting. By contrasting board role theories against different types of SMEs, firms are expected to recruit “outside”

Star scientists as drivers of the development of regions

This chapter investigates the location pattern (at the NUTS 2 level) of European-based star scientists (identified by the number of citations they generated in journals in the ISI database) as well as the degree and intensity of knowledge sharing activities performed by the scientific elite in their regions of choice. Using a unique dataset of 197 star scientists, we demonstrate that Europe’s worl

I industrisamhällets slagskugga. Om problematiska kulturarv

Kulturarv har sedan ett par år kopplats samman med begrepp som jämställdhet, demokrati, mångfald och representation. Konsekvenserna har blivit krav på att fler företeelser och berättelser ska ges ställning som kulturarv. Men vad händer när komplicerade, svåra eller på annat sätt problematiska företeelser betraktas som kulturarv? I boken undersöks den friktion som uppstår när sådana företeelser möt

Composite morphological functions for DT-CNNs

Mathematical morphology is a powerful means to specify image manipulations; discrete-time cellular neural networks (DT-CNN) is the fast realization. The attractive combination has been sufficiently shown for simple problems but tends to fail in efficiency for more complex ones. The paper introduces a complement and argument swap (CAS) equivalence that allows to solve an image processing problem th

Kamratgranskning av rapporter i kursen Systemteknik

Traditionellt har examinationen av många kurser på LTH bestått av en skriftlig tentamen efter kursen avslutande. Detta instrument för att mäta och värdera studenternas kunskaper har ofta i stor utsträckning styrt studenternas studievanor, ofta med intensivt tentaläsande som följd. Kamratgranskning, eller ”Peer Review”, är en metod som kan användas som en del i en löpande examination under kursen g